Tc-99m Labeled Monoclonal Antibodies Against Granulocytes (BW 250/183) in the Detection of Appendicitis

Biersack, H.-J.; Overbeck, B.; G, Ott; Kania, U.; Briele, B.; Kropp, J.; Bockisch, Andreas; Grünwald, Frank; Hotze, A.; Hirner, A.

doi:10.1097/00003072-199305000-00001

Cited by 18 publications

(6 citation statements)

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“…The main indications elaborated have been delineated in published papers. Aside from bone marrow scintigraphy which was not investigated in the study under discussion here, the indications were consistent with the main areas studied in the present clinical trial: inflammatory changes involving joints, joint prostheses and the (peripheral) skeleton (14,21,24,48,57,62,63), abdominal inflammatory disorders, particularly involving the intestine (11,38,46,65), endocarditis (3,45), and febrile episodes of unknown aetiology (5,7,25,42).…”

Section: Indicationssupporting

confidence: 83%

Granulocyte Labelling Kit BW 250/183

Oberhausen¹,

Steinsträβer²

1996

Nuklearmedizin

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SummaryIn 6 European countries a multicenter trial with the technetium-99m labelled monoclonal anti-granulocyte antibody BW 250/183 was conducted in 775 patients. The antibody is used for the immunoscintigraphic visualisation of accumulations of granulocytes. The present study was restricted on the investigation of patients having inflammations, essentially of the peripheral skeleton (mostly of the lower extremities), spinal column, the bowel, or had fever of unknown etiology.The overall sensitivity of the method was 83%, and specificity was of the same order of magnitude (82%). The procedure yielded additional information in 67% of the cases and the treatment strategy was influenced in 35% of the cases to positive effect, even though all conventional methods had previously been exhausted. Human anti mouse-IgG antibodies (HAMA) were detectable only in about 4% of patients investigated for the first time.

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Section: Indicationssupporting

confidence: 83%

Granulocyte Labelling Kit BW 250/183

Oberhausen¹,

Steinsträβer²

1996

Nuklearmedizin

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“…On the other side, a normal appendix is reported in 15-40 % of patients who undergo appendectomy [17]. Different imaging modalities have been used with varying accuracy to address this dilemma, and different scintigraphic techniques have been reported to contribute to the diagnosis of suspicious appendicitis [5,[21][22][23]. 99m Tc-labeled UBI is a synthetic antimicrobial peptide, which is used recently for detection of fungal and bacterial infections with high sensitivity and specificity [10,24,25].…”

Section: Discussionmentioning

confidence: 99%

Poor sensitivity of 99mTc-labeled ubiquicidin scintigraphy in diagnosis of acute appendicitis

et al. 2014

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Poor sensitivity of 99m Tc-labeled ubiquicidin scintigraphy in diagnosis of acute appendicitis 173 1 3 SummaryBackground Ubiquicidin 29-41 (UBI) is an antimicrobial peptide.Methods In total eight men and two women with high probability of acute appendicitis were serially imaged for up to 30 min after the intravenous administration of 370 MBq of 99m Tc-UBI, before surgical exploration.Results The scan showed mild to moderate increased uptake in the right lower quadrant in six patients. Quantitative analysis failed to show any difference between suppurative and gangrenous appendicitis.Conclusion 99m Tc-UBI scintigraphy has 20 % sensitivity for diagnosis of acute appendicitis.

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“…Other radiolabelled antigranulocyte antibodies have also been investigated but do not seem to be superior to 99m technetium-labelled HMPAO scanning (196,197). Immunoglobulin G antibody scans may offer more promise, but only the results of preliminary trials have been reported (198,199).…”

Section: Nuclear Imagingmentioning

confidence: 99%

The Role of Radiological Imaging in the Diagnosis of Acute Appendicitis

Albiston¹

2002

Canadian Journal of Gastroenterology

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Several strategies have been employed to improve the accuracy of the diagnosis of appendicitis and to reduce the associated perforation rate. Because clinical algorithms have been disappointing, many physicians resort to radiological modalities. Plain abdominal x-rays are nonspecific, barium enema examination has relatively low accuracy, scintigraphy scans require considerable time and are difficult to interpret, and magnetic resonance imaging is relatively unstudied. The most promising modalities are graded compression sonography and computed tomography. In expert hands, these techniques can achieve a high degree of accuracy. Nevertheless, most published studies have been marred by methodological difficulties. Moreover, ultrasound is more useful in detecting than in ruling out appendicitis. The radiological criteria for acute appendicitis, the accuracy of various imaging modalities and the limitations of the available research are described.

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Tc-99m Labeled Monoclonal Antibodies Against Granulocytes (BW 250/183) in the Detection of Appendicitis

Cited by 18 publications

References 0 publications

Granulocyte Labelling Kit BW 250/183

Granulocyte Labelling Kit BW 250/183

Poor sensitivity of 99mTc-labeled ubiquicidin scintigraphy in diagnosis of acute appendicitis

The Role of Radiological Imaging in the Diagnosis of Acute Appendicitis

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