TBX15 facilitates malignant progression of glioma by transcriptional activation of TXDNC5

Ge, Yuyuan; Jia, Bin; Zhang, Peng; Chen, Baomin; Liu, Liang; Shi, Yan; Huang, Shilu; Liu, Xinglei; Wang, Ran; Xie, Yandong; Li, Zhe; Dong, Jun

doi:10.1016/j.isci.2024.108950

Cited by 1 publication

(1 citation statement)

References 35 publications

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“…Ge et al. revealed that the TBX15/TXNDC5 axis play a crucial role in the genesis and progression of glioma; TBX15 exerts its oncogenic roles by regulating transcriptional activation of TXDNC5 ( 142 ). Overall, these results indicate that TXNDC5 is affected by different regulators in various cancers and that TXNDC5 plays an important role in promoting cancer proliferation, invasion and metastasis.…”

Section: Txndc5 and Tumor Tissuesmentioning

confidence: 99%

The role and mechanism of TXNDC5 in disease progression

Jiao,

Zhang,

Song

et al. 2024

Front. Immunol.

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Thioredoxin domain containing protein-5 (TXNDC5), also known as endothelial protein-disulfide isomerase (Endo-PDI), is confined to the endoplasmic reticulum through the structural endoplasmic reticulum retention signal (KDEL), is a member of the PDI protein family and is highly expressed in the hypoxic state. TXNDC5 can regulate the rate of disulfide bond formation, isomerization and degradation of target proteins through its function as a protein disulfide isomerase (PDI), thereby altering protein conformation, activity and improving protein stability. Several studies have shown that there is a significant correlation between TXNDC5 gene polymorphisms and genetic susceptibility to inflammatory diseases such as rheumatoid, fibrosis and tumors. In this paper, we detail the expression characteristics of TXNDC5 in a variety of diseases, summarize the mechanisms by which TXNDC5 promotes malignant disease progression, and summarize potential therapeutic strategies to target TXNDC5 for disease treatment.

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Section: Txndc5 and Tumor Tissuesmentioning

confidence: 99%