TBADT‐Mediated Photocatalytic Stereoselective Radical Alkylation of Chiral N‐Sulfinyl Imines: Towards Efficient Synthesis of Diverse Chiral Amines

Abstract

Herein we describe a sustainable and efficient photocatalytic method for the stereoselective radical alkylation of chiral sulfinyl imines. By employing readily available non‐prefunctionalized radical precursors and low loading of TBADT as a direct HAT photocatalyst, we successfully obtain diverse chiral amines with high yields and excellent diastereoselectivity under mild conditions. This method provides an efficient approach for accessing a diverse array of medicinally relevant compounds, including both natural and synthetic α‐amino acids, aryl ethyl amines, and other structural motifs commonly found in approved pharmaceuticals and natural product.

Engineering the heterogeneous photocatalytic activity of crystalline decatungstate-based coordination polymers

“…1 DT in a solution containing organic substrates could be easily reduced with appearance of blue color when irradiated with UV light, which signified its potential to act as a promising photocatalyst. 2,3 Recently, the decatungstate anion has attracted growing attention due to its outstanding photocatalytic performance in various reactions, including activation of inert C(sp 3 )–H bonds via hydrogen atom transfer (HAT) or single electron transfer (SET), 4–6 oxidation of organic substrates, 7–11 degradation of organic pollutants, 12,13 etc. However, commonly used DT-based photocatalytic catalysts, such as (Bu 4 N) 4 [W 10 O 32 ] (TBADT) and Na 4 [W 10 O 32 ] (NaDT), were known to have a relatively low light harvesting efficiency.…”