Tazarotene 0.1% gel for psoriasis of the fingernails and toenails: an open, prospective study

Treatment of Psoriatic Nails with Tazarotene Cream 0.1% vs. Clobetasol Propionate 0.05% Cream: A Double-blind Study

“…Discontinuation of therapy resulted in significant regression ofthe signs for both groups, with the exception of hyperkeratosis, which seemed to retain significant improvement 12 weeks after the end of treatment for the patients applying tazarotene. These results tend to confirm previous studies reporting good clinical response after treatment with tazarotene gel in both fingernails and toe-nails (2,3). Although clobetasol cream at a concentration of 0.05% is generally thought to present poor efficacy in the control of nail psoriasis because of limited penetration, our experience suggests that it has encouraging efficacy comparable to that of tazarotene under occlusion.…”

“…The therapeutic potential of tazarotene 0.1% gel in nail psoriasis has been evaluated in one open-label study (2) and one placebocontrolled study (3) with promising results.…”

Treatment and Management of Psoriasis with Nail Involvement: A Focus on Biologic Therapy

“…Both treatments were found to improve pitting, hyperkeratosis, onycholysis and salmon patches after 12 weeks (p < 0.001), although there was no statistically significant difference between the 2 treatments [22]. Lastly, an open study of tazarotene 0.1% gel demonstrated a good clinical response in 19 of 25 patients who completed the 12-week treatment protocol [23]. Nails were only visually assessed, with no standardised method of assessment used, and no occurrences of complete clearance were reported.…”

“…Nails were only visually assessed, with no standardised method of assessment used, and no occurrences of complete clearance were reported. However, recurrences were reported 24 weeks post treatment [23]. …”

Current treatment options in psoriasis: topical agents

“…In a study of 25 patients with nail psoriasis, 19 showed a good clinical response after 12 weeks of tazarotene 0.1% gel application, with overall decrease in visual assessment of onycholysis, hyperkeratosis, oil spots, pitting and other nonspecific signs (p < 0.0001) [50]. Tazarotene monotherapy is limited by skin irritation.…”