Taylor-Vortex Bioreactors for Enhanced Mass Transport

Effect of the fluid shear rate on the induction time of CO2‐THF hydrate formation

“…for a low Re i . However, they also found that this increase was much lower (k is [47,54] proportional to Re i 0.20 ) once the transition boundary between a CCF to a TVF had been passed, i.e. for Re i > 141 (or Ta > Ta c ).…”

“…In their two studies, Curran and Black [47,54] also investigated the influence of Re i on gas-liquid mass transfer (from the headspace through the free surface of the liquid) and axial mass transport in the liquid between the two cylinders. They defined an overall mass transfer coefficient (k) and determined that this coefficient increased sharply with the increase in Re i (k is proportional to Re i 2.98 ) as long as the flow was a CCF, i.e.…”

“…The nature of the flow regimes generated in the solution during our experiments can be deduced from the results of two studies by Curran and Black, who used a slightly modified commercial concentric‐cylinder rheometer as an annular‐flow bioreactor. It had almost the same dimensions as the one used in the present study.…”

Ultraviolet/ozone treated polystyrene microcarriers for animal cell culture

“…Microcarriers are typically 100–450 µm in diameter and offers very large surface area per unit culture volume for cell attachment . However, the size distribution of microcarriers should be narrower because it is important for good mixing in a bioreactor, homogenous suspension of microcarriers, equal distribution of cells between microcarriers so that confluence of cells can be reached at about the same time on each microcarrier, and also for equal sedimentation during scale‐up steps in large‐scale processes .…”

Investigation of perfusion culture for developing 3D constructs in tissue engineering

“…While the system designs could vary from experiment to experiment, this work has explored the flow dependence on some common modular system designs. The obtained knowledge helps tissue engineers to evaluate the flow profile in perfusion systems and design perfusion systems for applying suitable flow stimulations to 3D constructs.4 CHAPTER FOUR-A MATHEMATICAL MODEL FOR FLOWSHEAR-SENSITIVE 3D TISSUE CONSTRUCT DEVELOPMENT4.1 INTRODUCTIONDynamic culture not only improves the mass exchange between cells and the medium, but also exposes cells to physical stimulations[131][132][133]. It has proven to have important regulating effects on cell secretion, alignment, mobility and attachment[134][135].…”