Taxonomy and Genetics

Fox, R. R.

doi:10.1016/b978-0-12-469235-0.50007-5

Cited by 25 publications

(18 citation statements)

References 212 publications

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“…A similar response was seen in adult, but not fully mature, rabbit soleus muscles (Tardieu et al 1981). The fact that the animals used in the present study had a mean body weight of 2-5 kg, whereas fully mature female rabbits of this strain weigh 4-5-5 kg (Fox, 1974), may explain the reduced muscle length seen after the longer periods of immobilization. Although no direct measurements were made, it was evident during dissection of the immobilized limb that the TA tendon had greatly elongated in comparison with both the contralateral limb and unoperated controls.…”

Section: Methodsmentioning

confidence: 78%

Effects of lengthened immobilization on functional and histochemical properties of rabbit tibialis anterior muscle

Pattullo¹,

Cotter²,

Cameron³

et al. 1992

Experimental Physiology

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SUMMARYThe imposition of long-term lengthened immobilization on rabbit tibialis anterior (TA) muscles resulted in rapid increases in slow oxidative (SO) fibre number. After 2 weeks, SO number had increased 2-fold and was 5 times greater after 6 weeks immobilization. There were also fibre-type-specific effects on SO, fast oxidative glycolytic (FOG) and fast glycolytic (FG) fibre areas. Twitch strength was unchanged throughout immobilization whilst production of tetanic tension was impaired during the initial period but had returned to control levels by 6 weeks. Twitch contraction times and isometrically determined rates of rise and relaxation were largely unaffected by immobilization despite the marked increase in expression of slow myosin. The change in phenotypic expression of the lengthened TA was not attributable to chronically increased levels of activation since integrated EMG activity was unchanged from control values throughout the immobilization period. Thus it is suggested that a chronic increase in tension consequent on the lengthening procedure is a potent stimulus for fast-to-slow myosin transformation.

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Section: Methodsmentioning

confidence: 78%

Effects of lengthened immobilization on functional and histochemical properties of rabbit tibialis anterior muscle

Pattullo¹,

Cotter²,

Cameron³

et al. 1992

Experimental Physiology

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“…The order of dominance is the following: E D > E S > E > e J > e , with possible partial dominance of E D over E S and of E S over E [3,32-34]. Sequencing almost the complete coding sequence (CDS) of the rabbit MC1R gene, we recently identified two in-frame deletions associated with dominant black (c.280_285del6; alleles E D and/or E S ) and recessive red (c.304_333del30; allele e ) coat colours, respectively [35].…”

Section: Introductionmentioning

confidence: 99%

A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with the Japanese brindling coat colour in rabbits (Oryctolagus cuniculus)

et al. 2010

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BackgroundIn the domestic rabbit (Oryctolagus cuniculus), classical genetic studies have identified five alleles at the Extension locus: ED (dominant black), ES (steel, weaker version of ED), E (wild type, normal extension of black), eJ(Japanese brindling, mosaic distribution of black and yellow) and e (non-extension of black, yellow/red with white belly). Sequencing almost the complete coding sequence (CDS) of the rabbit MC1R gene, we recently identified two in-frame deletions associated with dominant black (c.280_285del6; alleles ED or ES) and recessive red (c.304_333del30; allele e) coat colours. It remained to characterize the eJallele whose phenotypic effect is similar to the Orange and Sex-linked yellow loci of cat and Syrian hamster.ResultsWe sequenced the whole CDS in 25 rabbits of different coat colours including 10 Japanese and 10 Rhinelander (tricolour) rabbits and identified another 6 bp-in frame deletion flanked by a G > A transition in 5' (c.[124G>A;125_130del6]) that was present in all animals with Japanese brindling coat colour and pattern. These mutations eliminate two amino acids in the first transmembrane domain and, in addition, cause an amino acid substitution at position 44 of the wild type sequence. Genotyping 371 rabbits of 31 breeds with different coat colour this allele (eJ) was present in homozygous state in Japanese, Rhinelander and Dutch tricolour rabbits only (except one albino rabbit). Rabbits with eJ/eJ genotype were non fixed at the non-agouti mutation we previously identified in the ASIP gene. Segregation in F1 and F2 families confirmed the order of dominance already determined by classical genetic experiments with a possible dose effect evident comparing eJ/eJ and eJ/e animals. MC1R mRNA was expressed in black hair skin regions only.ConclusionsThe c.[124A;125_130del6] allele may be responsible for a MC1R variant determining eumelanin production in the black areas. However, the mechanism determining the presence of both red and black hairs in the same animal seems more complex. Expression analyses of the c.[124A;125_130del6] allele suggest that MC1R transcription may be regulated epigenetically in rabbits with the Japanese brindling phenotype. Further studies are needed to clarify this issue.

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“…S. nuttallii exists in the western USA from Dakota to central New Mexico while S. audubonii has a broader distribution through the southwestern USA and Mexico (Fox, 1994). S. audubonii overlaps with S. bachmani through part of its range and is exposed to myxoma virus whereas S. nuttallii has no known exposure to myxoma virus.…”

Section: Introductionmentioning

confidence: 99%

Host-specificity of myxoma virus: Pathogenesis of South American and North American strains of myxoma virus in two North American lagomorph species

Silvers

Barnard

Knowlton

et al. 2010

Veterinary Microbiology

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Taxonomy and Genetics

Cited by 25 publications

References 212 publications

Effects of lengthened immobilization on functional and histochemical properties of rabbit tibialis anterior muscle

Effects of lengthened immobilization on functional and histochemical properties of rabbit tibialis anterior muscle

A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with the Japanese brindling coat colour in rabbits (Oryctolagus cuniculus)

Host-specificity of myxoma virus: Pathogenesis of South American and North American strains of myxoma virus in two North American lagomorph species

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