Taxonomic studies on the genus Rhabdosciadium (Apiaceae) with particular reference to Turkish species and their relationships with some closely related genera

Duran, Ahmet; Dogan, Belgin; Duman, Hayrí; Martın, Esra; Öztürk, Meltem; Çetin, Özlem

doi:10.2478/s11756-010-0032-8

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…R. microcalycinum Hand.‐Mazz. dichotomously branched below and middle part; peduncle 0–5 mm, with 4–6 bracteate, ray 3–4 (−5), unequal, 7–15 mm; stilopodium embedded in corky mericarps, slightly conical [3,4] …”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Anticancer, Antioxidant, Antidiabetic and Anticholinergic Potentials of Endemic Rhabdosciadium microcalycinum Supported by Molecular Docking Study

et al. 2022

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Lung cancer is the most common cancer worldwide and the leading cause of cancer‐related death. Plant‐derived natural products and compounds are an inspiring source of chemotherapeutic agents. Alzheimer's disease (AD) is linked to the decline of acetylcholine (ACh) effects in the brain, so acetylcholinesterase (AChE) inhibitors are important in the treatment of AD. In this study, the chemical components and bioactivity of ethanolic extract of Rhabdosciadium microcalycinum (RM) was investigated by various methods. The lipophilic components of RM was determined by gas chromagraphy‐mass spectrometry (GC‐MS). Antioxidant activicty tests were evaluated with FCAP (Ferrous chelating antioxidant power assay), FRAP (Ferric reducing antioxidant power assay), ABTS (2,2′‐Azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) diammonium salt assay) and DPPH (2,2‐diphenyl‐1‐picrylhydrazyl assay). The anticancer effect of RM was evaluated by WST‐1 (4‐[3‐(4‐iodophenyl)‐2‐(4‐nitrophenyl)‐2H‐5‐tetrazolio]‐1,3‐benzene disulfonate), colony formation, wound healing and CDDE (cell death detection Elisa) analysis on A549 lung cancer cells. Enzyme inhibition effects of RM was determined against AChE and α‐glycosidase (AG) enzymes. According to the results of molecular docking found in the study; With a docking score of −4.56 for HP5 protein, −6.23 for BXO protein, −5.25 for AFI protein, −3.90 for gly protein and −7.74 for AChE protein, Telecinobufagin molecule was found to have higher activity than other molecules. After docking calculations, Absorption, Distribution, Metabolism, Excretion and Toxicity (ADME/T) analysis was performed to examine the effects and reactions of molecules on human metabolism. RM inhibited the viability of A549 cells dose‐dependent manner (IC50=117.15±8.58 μg/mL), and it was also observed that RM suppressed colony formation, prevented cell migration and directed the cells to apoptosis. RM has important lipophilic components, and significant antioxidant and enzyme inhibition potential. IC50 values of RM for AChE and AG enzymes were found as 35.86 mg/mL, and 10.14 mg/mL, respectively. In conclusion, the findings of this study reveal that ethanol extract from the aerial part of Rhabdosciadium microcalycinum may be a potential therapeutic agent for the treatment of human lung cancer and Alzheimer's disease, due to its phytochemical components.

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Section: Introductionmentioning

confidence: 99%

The Evaluation of Anticancer, Antioxidant, Antidiabetic and Anticholinergic Potentials of Endemic Rhabdosciadium microcalycinum Supported by Molecular Docking Study

et al. 2022

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“…They are quite rare at tropical humid regions which limited in high mountains. The Apiaceae species are present at all types of habitats, in sea-level to alpine zones: aquatic biotopes, grasslands, grazed pastures, forests have their clearings and margins, screes, rocky hills, cliffs,, open sandy, gravelly soils, steppes, cultivated fields, fallows, waste grounds and road sides [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Checklist of the Umbelliferae family in the herbarium of Iraq natural history museum

Al-Joboury¹

2021

GSC Biol. and Pharm. Sci.

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The aim of this study is to make the inventory for Umbelliferae family for the purpose of identifying the samples that were collected over long periods and saved in the herbarium of Iraq Natural History Museum/ University of Baghdad. We found that the herbarium plants were very large and varied from different parts for Iraq, in different and varied environments, which collected and arranged according to a very specific system in the herbarium for remaining an important source to all graduate students and researchers to take advantage for these plants. Also, the flowering and fruiting periods for these plants in Iraq were recorded in different regions. Most these plants begin to flower in the spring and thrive at fields and farms.

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“…The Apiaceae family is classified into three subfamilies that the largest of them is the Apioideae (Plunkett & Downie, 1999). Apiaceae family includes about 450 genera and 3700 species in all around the world that are rich in secondary metabolites including many valuable genera in terms of economic and medical importance (Duran et al, 2010;Olle & Bender, 2010). The plants belonging to the Apiaceae family have its own distinctive features such as umbel inflorescences, actionomorphic and five merous corolla, inferior ovary with two locules and the schisocarp fruits that are separated from each other by carpophor.…”

Section: Introductionmentioning

confidence: 99%

Studying the morphological diversity of Bunium paucifolium and some Elwendia species (Apiaceae)

2020

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The genus Bunium L. (Apiaceae) has about 50 species in the world, distributed in Asia, Europe and North Africa. Recently, Bunium has been divided into two separate genera Elwendia and Bunium. Kerman province is the largest province in Iran and has a wide distribution of these genera especially E. persica, as the most important medicinal and spice species. There are a few published studies on the morphology of these genera, especially on flower and fruit morphology. 20 morphological traits were studied to analyze the differences between species. The most important traits in the first principal component analysis (PCA1) were the number of bracts and umbellets per umbel, stylopodial length, corolla shape, empty fruits and the number of flowers and fruits per umbellet. Corolla shape was raised and vertical in B. paucifolium while horizontal and wide in three other species (E. cylindrica, E. persica and E. wolffii). There are 3 to 4 male flowers in the center of umbellet in E. cylindrica, E. wolffii and B. paucifolium while in E. Persica, no male flowers were observed. This study revealed that morphological traits particularly corolla shape are consistent with the molecular phylogenetic results reported by other researchers.

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Taxonomic studies on the genus Rhabdosciadium (Apiaceae) with particular reference to Turkish species and their relationships with some closely related genera

Cited by 9 publications

References 12 publications

The Evaluation of Anticancer, Antioxidant, Antidiabetic and Anticholinergic Potentials of Endemic Rhabdosciadium microcalycinum Supported by Molecular Docking Study

The Evaluation of Anticancer, Antioxidant, Antidiabetic and Anticholinergic Potentials of Endemic Rhabdosciadium microcalycinum Supported by Molecular Docking Study

Checklist of the Umbelliferae family in the herbarium of Iraq natural history museum

Studying the morphological diversity of Bunium paucifolium and some Elwendia species (Apiaceae)

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