“…However, due to the lack of homologous IFN preparations, no in vivo data on the efficacy of IFN in infected psittacines are available. The nucleoside analogue ribavirin is active against a broad range of RNA viruses (Day et al, 2005;Graci et al, 2007;Gu et al, 2006;Leyssen et al, 2005;Moreno et al, 2011;Pauly & Lauring, 2015;Severson et al, 2003), including the mammalian Borna disease virus 1 (BoDV-1), which is a close relative of the avian bornaviruses (Kuhn et al, 2015). Several studies demonstrated that ribavirin can inhibit BoDV-1 in mammalian cell lines (Jordan et al, 1999;Mizutani et al, 1998Mizutani et al, , 1999 as well as in experimentally infected gerbils (Lee et al, 2008).…”