Taxonomic identification and bioactive compounds characterization of Psilocybe cubensis DPT1 to probe its antibacterial and mosquito larvicidal competency

Anti-Inflammatory Effects of Four Psilocybin-Containing Magic Mushroom Water Extracts in vitro on 15-Lipoxygenase Activity and on Lipopolysaccharide-Induced Cyclooxygenase-2 and Inflammatory Cytokines in Human U937 Macrophage Cells

“…Previous studies have revealed the presence of mycochemical compounds in psilocybin-containing mushrooms such as alkaloids and saponins which are known as potent antioxidants that neutralize free radicals and flavonoids with antioxidant and anti-inflammatory activities and also tannins with antioxidant properties especially in Pan cyanescens and P. cubensis . 32 , 33 We have also previously reported the presence of well-known anti-inflammatory and antioxidant compounds in P. natalensis mushroom extracts. 24 Moreover, our previous study also showed a significant inhibition of ROS displayed by Pan cyanescens and P. cubensis in a pathological hypertrophy condition.…”

“…32 Studies have also shown that inhibition of COX-2 expression have suppressive effects on OA. 33 Moreover, in the study of Yang et al 31 where IL-1β was used to induce a degenerated chondrocyte model of hypertrophy, there was an up-regulated increase in the expressions of many proteins and enzymes including COX-2, PGE-2, and collagen X which were reversed by treatment with a potent COX-2 inhibitor used in the study. 31 As a result, the ability of the hot-water extracts of the four magic mushrooms to significantly inhibit especially the induced-IL-1β and also lower the induced-COX-2 levels (significantly with P. A+ strain treatment), make them a great agent for use in treatment of inflammatory diseases such as AO.…”

Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes

“…A further study into the mechanisms of action in vitro www.nature.com/scientificreports/ and in vivo is therefore recommended. Furthermore, in previous studies, mycochemical compounds were verified to be present in both Pan cyanescens and P. cubensis mushrooms such as alkaloids, with known biological activities including toxicity against cells of foreign organisms 22,30 . Saponins which are known as potent antioxidant that neutralises free radicals and flavonoids with antioxidant, anti-inflammatory and anti-carcinorgenic activities 22,30 .…”

“…Furthermore, in previous studies, mycochemical compounds were verified to be present in both Pan cyanescens and P. cubensis mushrooms such as alkaloids, with known biological activities including toxicity against cells of foreign organisms 22,30 . Saponins which are known as potent antioxidant that neutralises free radicals and flavonoids with antioxidant, anti-inflammatory and anti-carcinorgenic activities 22,30 . Finally, tannins with antioxidant properties related to their scavenging activities reported to have been used against heart diseases were also detected in the two mushrooms 22,30 .…”

“…Saponins which are known as potent antioxidant that neutralises free radicals and flavonoids with antioxidant, anti-inflammatory and anti-carcinorgenic activities 22,30 . Finally, tannins with antioxidant properties related to their scavenging activities reported to have been used against heart diseases were also detected in the two mushrooms 22,30 . Presence of these compounds could have also played a role in the protective activities exhibited by the water extracts of Pan cyanescens and P. cubensis mushrooms in the study.…”