Taxonomic Composition and Diversity of the Gut Microbiota in Relation to Habitual Dietary Intake in Korean Adults

Noh, Hwayoung; Kim, Gi-Chang; Zouiouich, Semi; Cho, Suyeon; Kim, Hyeon-Jeong; Kim, Jeongseon; Choe, Jeong‐Sook; Gunter, Marc J.; Ferrari, Pietro; Scalbert, Augustin; Freisling, Heinz

doi:10.3390/nu13020366

Cited by 21 publications

(10 citation statements)

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“…Preclinical studies for colon cancer suggest that consumption of mixed nuts, walnuts, and almonds inhibits DNA damage and tumor growth through the suppression of angiogenesis, proliferation, and inflammation, as well as increased apoptosis and favorable alterations to the gut bacteria and enterotype-like clusters [ 78 , 79 , 80 , 81 , 82 , 83 ]. In line with the latter, a cross-sectional study among 222 Koreans showed that a healthy dietary pattern characterized by higher intakes of nuts/seeds was related to higher α-diversity reflecting gut microbial health [ 84 ].…”

Section: Tree Nuts Peanuts and Cancermentioning

confidence: 96%

Dried Fruits, Nuts, and Cancer Risk and Survival: A Review of the Evidence and Future Research Directions

et al. 2023

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Dried fruits and nuts contain high amounts of nutrients and phytochemicals—all of which may have anticarcinogenic, anti-inflammatory, and antioxidant properties. This narrative review summarizes the evidence for dried fruits and nuts and cancer incidence, mortality, and survival and their potential anticancer properties. The evidence for dried fruits in cancer outcomes is limited, but existing studies have suggested an inverse relationship between total dried fruit consumption and cancer risk. A higher consumption of nuts has been associated with a reduced risk of several site-specific cancers in prospective cohort studies, including cancers of the colon, lung, and pancreas, with relative risks per 5 g/day increment equal to 0.75 (95% CI 0.60, 0.94), 0.97 (95% CI 0.95, 0.98), and 0.94 (95% CI 0.89, 0.99), respectively. A daily intake of total nuts of 28 g/day has also been associated with a 21% reduction in the rate of cancer mortality. There is also some evidence that frequent nut consumption is associated with improved survival outcomes among patients with colorectal, breast, and prostate cancer; however, further studies are needed. Future research directions include the investigation of additional cancer types, including rare types of cancer. For cancer prognosis, additional studies with pre- and postdiagnosis dietary assessment are warranted.

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Section: Tree Nuts Peanuts and Cancermentioning

confidence: 96%

Dried Fruits, Nuts, and Cancer Risk and Survival: A Review of the Evidence and Future Research Directions

et al. 2023

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“…A similarity between the diets of Korean (52 million population, land area 100,200 km 2 ) and Japanese (127 million population, land area 378,000 km 2 ) is the heavy consumption of fermented foods such as fermented vegetables (e.g., kimchi, natto, and tsukemono), soybean paste, fish products, red pepper paste, medicinal herbs, and sesame or perilla oil ( Kim et al, 2016 ), originally developed to cover for shortfalls in food during winter. The intakes of fermented legumes, vegetables, and potatoes were found to be positively associated with higher α-diversity and F:B ratio in the Korean NAS-IARC cohort ( Noh et al, 2021 ). A metagenomic analysis of kimchi revealed dominating members of Leuconostoc , Lactobacillus , and Weissella ( Jung et al, 2011 ), with the latter recently isolated and identified in traditional Indian fermented foods ( Månberger et al, 2020 ).…”

Section: Regional Dietary Patterns and Associated Gut Microbiome Trendsmentioning

confidence: 98%

Regional Diets Targeting Gut Microbial Dynamics to Support Prolonged Healthspan

et al. 2021

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In the last 150 years, we have seen a significant increase in average life expectancy, associated with a shift from infectious to non-communicable diseases. The rising incidence of these diseases, for which age is often the largest risk factor, highlights the need for contemporary societies to improve healthy ageing for their growing silver generations. As ageing is an inevitable, non-reversing and highly individualised process, we need to better understand how non-genetic factors like diet choices and commensal gut microbes can modulate the biology of ageing. In this review, we discuss how geographical and ethnic variations influence habitual dietary patterns, nutrient structure, and gut microbial profiles with potential impact on the human healthspan. Several gut microbial genera have been associated with healthy elderly populations but are highly variable across populations. It seems unlikely that a universal pro-longevity gut microbiome exists. Rather, the optimal microbiome appears to be conditional on the microbial functionality acting on regional- and ethnicity-specific trends driven by cultural food context. We also highlight dietary and microbial factors that have been observed to elicit individual and clustered biological responses. Finally, we identify next generation avenues to modify otherwise fixed host functions and the individual ageing trajectory by manipulating the malleable gut microbiome with regionally adapted, personalised food intervention regimens targeted at prolonging human healthspan.

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“…Even though studies have shown associations between diet and gut microbiota (26)(27)(28)(29)(30)(31), studies investigating metabolic markers associated with both gut microbiota and diet in healthy adults are scarce (32)(33)(34)(35). Identifying specific gut bacteria associated with both diet and metabolic markers may be valuable and could represent a potential strategy for the prevention of disease.…”

Section: Popular Scientific Summarymentioning

confidence: 99%

Gut microbiota is associated with dietary intake and metabolic markers in healthy individuals

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Myhrstad

Rud

et al. 2022

Food & Nutrition Research

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Background: Metabolic diseases have been related to gut microbiota, and new knowledge indicates that diet impacts host metabolism through the gut microbiota. Identifying specific gut bacteria associated with both diet and metabolic risk markers may be a potential strategy for future dietary disease prevention. However, studies investigating the association between the gut microbiota, diet, and metabolic markers in healthy individuals are scarce. Objective: We explored the relationship between a panel of gut bacteria, dietary intake, and metabolic and anthropometric markers in healthy adults. Design: Forty-nine volunteers were included in this cross-sectional study. Measures of glucose, serum triglyceride, total cholesterol, hemoglobin A1c (HbA1c), blood pressure (BP), and body mass index (BMI) were collected after an overnight fast, in addition to fecal samples for gut microbiota analyzes using a targeted approach with a panel of 48 bacterial DNA probes and assessment of dietary intake by a Food Frequency Questionnaire (FFQ). Correlations between gut bacteria, dietary intake, and metabolic and anthropometric markers were assessed by Pearson's correlation. Gut bacteria varying according to dietary intake and metabolic markers were assessed by a linear regression model and adjusted for age, sex, and BMI. Results: Of the 48 gut bacteria measured, 24 and 16 bacteria correlated significantly with dietary intake and metabolic and/or anthropometric markers, respectively. Gut bacteria including Alistipes, Lactobacillus spp., and Bacteroides stercoris differed according to the intake of the food components, fiber, sodium, saturated fatty acids, and dietary indices, and metabolic markers (BP and total cholesterol) after adjustments. Notably, Bacteroides stercoris correlated positively with the intake of fiber, grain products, and vegetables, and higher Bacteroides stercoris abundance was associated with higher adherence to Healthy Nordic Food Index (HNFI) and lower diastolic BP after adjustment. Conclusion: Our findings highlight the relationship between the gut microbiota, diet, and metabolic markers in healthy individuals. Further investigations are needed to address whether these findings are causally linked and whether targeting these gut bacteria can prevent metabolic diseases.

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Taxonomic Composition and Diversity of the Gut Microbiota in Relation to Habitual Dietary Intake in Korean Adults

Cited by 21 publications

References 63 publications

Dried Fruits, Nuts, and Cancer Risk and Survival: A Review of the Evidence and Future Research Directions

Dried Fruits, Nuts, and Cancer Risk and Survival: A Review of the Evidence and Future Research Directions

Regional Diets Targeting Gut Microbial Dynamics to Support Prolonged Healthspan

Gut microbiota is associated with dietary intake and metabolic markers in healthy individuals

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