Taxol production by <i>Pestalotiopsis terminaliae</i>, an endophytic fungus of <i>Terminalia arjuna</i> (arjun tree)

Gangadevi, V.; Muthumary, J.

doi:10.1042/ba20070243

Cited by 107 publications

(51 citation statements)

References 21 publications

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“…An endophytic fungus Pestalotiopsis terminaliae was isolated from the same medicinal plant was produced Taxol about 211.1 μg/l, and the fungal Taxol extracted from the organic extract of this fungal culture, had strong cytotoxic activity towards BT 220, H116, Int 407, HL 251 and HLK 210 human cancer cells in vitro, tested by Apoptotic assay [17]. With the discovery that certain endophytic fungi are able to produce Taxol has brought the possibility that a cheaper and more widely available product may eventually be available via industrial fermentation.…”

Section: Resultsmentioning

confidence: 99%

A Novel Endophytic Taxol-Producing Fungus Chaetomella raphigera Isolated From a Medicinal Plant, Terminalia arjuna

Gangadevi

Muthumary

2009

Appl Biochem Biotechnol

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Taxol is the most important member of the clinically useful natural anticancer drug. An endophytic fungus Chaetomella raphigera (strain TAC-15) was isolated from a medicinal plant Terminalia arjuna and screened for its potential in Taxol production. The fungus was identified based on the morphology of the fungal culture and the characteristics of the spores. This fungus was grown in MID liquid medium and analyzed by chromatographically and spectrometrically for the presence of Taxol. The amount of Taxol produced by this endophytic fungus was quantified by HPLC which showed that it produced 79.6 microg/L, and further confirmative analyses were done by using UV, IR, FAB mass spectroscopy, and NMR spectroscopy. Thus, the fungus can serve as a potential material for fungus engineering to improve the production of Taxol.

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Section: Resultsmentioning

confidence: 99%

A Novel Endophytic Taxol-Producing Fungus Chaetomella raphigera Isolated From a Medicinal Plant, Terminalia arjuna

Gangadevi

Muthumary

2009

Appl Biochem Biotechnol

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“…[259] [263] Pestalotiopsis terminaliae T. arjuna [264] Pestalotiopsis versicolor T. cuspidata [262] Pezicula sp. T. chinensis [223] Phoma betae G. biloba [265] Phyllosticta melochiae Melochia corchorifolia [267] Phyllosticta sp.…”

Section: W Nobilis Catharanthus Roseusunclassified

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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Abstract:It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper.

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“…It has also been reported from Chaetomella raphigera , a second endophytic paclitaxel producer reported from Terminalia arjuna (Gangadevi and Muthumary 2009a , b ). The same scientists also reported the production of paclitaxel by Bartalinia robillardoides , an endophyte of Aegle marmelos (Gangadevi and Muthumary 2009a ). This is not a comprehensive list of paclitaxelproducing endophytes, and more producers are reported every year.…”

Section: Terpenesmentioning

confidence: 87%

Endophytic Fungi: Novel Sources of Anticancer Molecules

Kumar

Rai

Gaur

et al. 2013

Advances in Endophytic Research

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Cancer is an enormous global health burden, touching every region of the world. The term "anticancer" is based on the assessment of the authors of the paper of the cytotoxicity of each compound against specifi c cancer cell lines. Endophytic fungi, fungi that are residing asymptomatically in internal tissues of all higher plants, are of growing interest as promising sources of biologically active agents. Endophytic fungi are one of the most creative groups of secondary metabolite producers that play important biological roles for human life. This chapter mainly focuses on endophytic fungi, which produce anticancer bioactive compounds such as paclitaxel, podophyllotoxin, camptothecin, vinblastine, hypericin, and diosgenin. The uniqueness of the endophytic community of fungi is stressed as a promising source of novel compounds with anticancer activity. Endophytes represent a dependable source of specifi c secondary metabolites and can be manipulated both physicochemically and genetically to increase yields of desired metabolites and to produce novel analogues of active metabolites.

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Taxol production by Pestalotiopsis terminaliae, an endophytic fungus of Terminalia arjuna (arjun tree)

Cited by 107 publications

References 21 publications

A Novel Endophytic Taxol-Producing Fungus Chaetomella raphigera Isolated From a Medicinal Plant, Terminalia arjuna

A Novel Endophytic Taxol-Producing Fungus Chaetomella raphigera Isolated From a Medicinal Plant, Terminalia arjuna

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Endophytic Fungi: Novel Sources of Anticancer Molecules

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