Taxol-Induced Cellulitis after Extravasation: A Rarely Reported Event

Stein, Moshe; Drumea, Keren; Abu-Rasmi, Rasem; Haim, Nissim

doi:10.1097/00000421-199710000-00023

Cited by 16 publications

(9 citation statements)

References 3 publications

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“…Only mild skin and soft tissue lesions following paclitaxel extravasation which subsided within 2 weeks were observed in four cases by Du Bois et al [15]. Stein et al [16] and Raymond et al [17] each reported on one case with reversible cellulitis and sharply demarked erythema, local heat, and blisters following extravasation of paclitaxel. Berghmans and Klastersky [18] saw erythema, cellulitis, and small vesicles with peeling of the skin after 3 weeks and painless induration persisting for at least 3 months in one case of paclitaxel extravasation.…”

Section: Discussionmentioning

confidence: 99%

Extravasation of Paclitaxel (TAXOL<sup>®</sup>) – Clinical Course

Riedel¹,

Serke²,

Schönfeld³

et al. 1999

Oncol Res Treat

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Background: Clinical information on paclitaxel extravasation is scarce. A clinical course following paclitaxel extravasation is reported with an overview of the literature. Case Report: A 74-year-old male patient with small-cell lung cancer mistakenly received approximately 100 ml of a subcutaneous infusion containing approximately 60 mg of paclitaxel. A severe cutaneous reaction was seen within 30 min, followed by a systemic reaction with dizziness on day 2, fever and hypotension on day 5, and leuko- and thrombocytopenia on day 10. Sclerosis, hyperpigmentation, and neuropathic pain developed in the forearm and slowly subsided within 6–8 months. Conclusion: Paclitaxel extravasation may cause severe cutaneous and rarely even systemic reversible reactions. Paclitaxel must be considered a vesicant.

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Section: Discussionmentioning

confidence: 99%

Extravasation of Paclitaxel (TAXOL<sup>®</sup>) – Clinical Course

Riedel¹,

Serke²,

Schönfeld³

et al. 1999

Oncol Res Treat

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“…Due to several reports in the literature paclitaxel is classified as vesicant. Due to its chemical properties, paclitaxel persists for a long time in tissue, so that extensive necrosis can appear with delay [46]. The additives Cremophor ® EL and ethanol can cause phlebitis and hypersensitivity reactions independent of extravasation [47].…”

Section: Relevant Cytostatic Agents In Dermatologymentioning

confidence: 99%

Current recommendations for prevention and therapy of extravasation reactions in dermato‐oncology

Kähler¹,

Mustroph

Hauschild³

2008

J Deutsche Derma Gesell

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“…Some patients suffering from repeated episodes of what appears to be cellulitis actually have a non-infectious inflammatory disease. [61][62][63][64][65][66][67] Episodes of 'pseudoerysipelas' are particularly difficult to distinguish from infection, but may respond more quickly and consistently to anti-inflammatory than to antimicrobial therapy. 67 Lipodermatosclerosis can occasionally present repetitively as a tender red plaque on the lower leg above the medial malleolus in patients with venous insufficiency, mimicking recurrent infection.…”

Section: Cellulitismentioning

confidence: 99%

Complicated infections of skin and skin structures: when the infection is more than skin deep

DiNubile¹

2004

Journal of Antimicrobial Chemotherapy

179

168

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Skin and skin-structure infections are common, and range from minor pyodermas to severe necrotizing infections. Complicated infections are defined as involving abnormal skin or wounds, occurring in compromised hosts, or requiring surgical intervention. Classification schemes for these infections are varied and confusing. Distinguishing characteristics include the aetiological agent(s), clinical context and findings, depth of tissue involvement and rate of progression. The most common pathogens are aerobic Gram-positive cocci, but complicated infections frequently involve Gram-negative bacilli and anaerobic bacteria. Initial antibiotic therapy is usually empirical, and later modified by the results of stains and cultures of wound specimens. Broad-spectrum coverage is frequently needed for complicated infections. Ertapenem is a once-a-day parenteral Group 1 carbapenem antibiotic, recently licensed in the USA and Europe, which may assume an important role in treating some complicated skin and skin-structure infections. Surgical debridement is important for many complicated infections, and is the critical element in managing necrotizing fasciitis and myonecrosis.

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Taxol-Induced Cellulitis after Extravasation: A Rarely Reported Event

Cited by 16 publications

References 3 publications

Extravasation of Paclitaxel (TAXOL<sup>®</sup>) – Clinical Course

Extravasation of Paclitaxel (TAXOL<sup>®</sup>) – Clinical Course

Current recommendations for prevention and therapy of extravasation reactions in dermato‐oncology

Complicated infections of skin and skin structures: when the infection is more than skin deep

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