Taxol from Botryodiplodia theobromae (BT 115)—AN endophytic fungus of Taxus baccata

Venkatachalam, R.; Kamalraj, Subban; Paul, Muthumary John

doi:10.1016/j.jbiotec.2008.07.1823

Cited by 40 publications

(6 citation statements)

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“…The disclosures of endophytic sources of paclitaxel ( 1 ) have continued apace, and a summary of the isolation or detection of 1 in various endophytic fungi since 1993 is presented in Table . ,− Three aspects of these reports are worthy of note. The first is that initial yields of 1 from an individual endophyte can be significantly increas...…”

Section: Selected Known Alkaloids From Endophytesmentioning

confidence: 99%

Biologically Significant and Recently Isolated Alkaloids from Endophytic Fungi

Daley¹,

Cordell

2021

J. Nat. Prod.

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Section: Selected Known Alkaloids From Endophytesmentioning

confidence: 99%

Biologically Significant and Recently Isolated Alkaloids from Endophytic Fungi

Daley¹,

Cordell

2021

J. Nat. Prod.

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“…Investigations conducted on two endophytic strains of L. theobromae, BT155 isolated from Taxus baccata and MUBL-BT associated with leaves of the medicinal plant Morinda citrifolia showed the production of the antitumor agent named taxol ( 112 ) [ 39 , 43 ] ( Figure 14 ). Taxol (generic name paclitaxel) is one of the most important natural products in terms of biomedical application and commercial value (i.e., millions dollars per year) [ 110 ], which was originally isolated from the bark of Pacific yew, Taxus brevifolia in very low concentrations [ 111 ], but subsequently, many researchers reported on taxol-producing endophytic fungus.…”

Section: Secondary Metabolitesmentioning

confidence: 99%

Secondary Metabolites of Lasiodiplodia theobromae: Distribution, Chemical Diversity, Bioactivity, and Implications of Their Occurrence

Salvatore

Alves

Andolfi

2020

Toxins

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Lasiodiplodia theobromae is a plant pathogenic fungus from the family Botryosphaeriaceae that is commonly found in tropical and subtropical regions. It has been associated with many hosts, causing diverse diseases and being responsible for serious damages on economically important crops. A diverse array of bioactive low molecular weight compounds has been described as being produced by L. theobromae cultures. In this review, the existing literature on secondary metabolites of L. theobromae, their bioactivity, and the implications of their occurrence are compiled. Moreover, the effects of abiotic factors (e.g., temperature, nutrient availability) on secondary metabolites production are highlighted, and possible avenues for future research are presented. Currently, a total of 134 chemically defined compounds belonging to the classes of secondary metabolites and fatty acids have been reported from over 30 L. theobromae isolates. Compounds reported include cyclohexenes and cyclohexenones, indoles, jasmonates, lactones, melleins, phenols, and others. Most of the existing bioactivity studies of L. theobromae metabolites have assessed their potential phytotoxic, cytotoxic, and antimicrobial activities. In fact, its host adaptability and its ability to cause diseases in plants as well as in humans may be related to the capacity to produce bioactive compounds directly involved in host–fungus interactions.

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“…On the other hand, endophytic fungi are important components of the forest community and have been reported to contribute to plant ecology, fitness, evolution, even plant communities' structure, and diversity [3,28]. Since Taxomyces andreanae, a fungal endophyte which can produce taxol and related compounds, was isolated from T. brevifolia [34], a number of other fungi with the same capacity have been isolated from different Taxus species [39,43,44]. Several studies have indicated that the production of plant second metabolites may interact with endophytic fungi [16,25], but the interaction between them remains enigmatic.…”

Section: Introductionmentioning

confidence: 99%

Geographic and Tissue Influences on Endophytic Fungal Communities of Taxus chinensis var. mairei in China

Han

et al. 2012

Curr Microbiol

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Endophytc fungi were collected from the barks, branches and leaves of Taxus chinensis var. mairei from the Jiangxi, Zhejiang and Chongqing regions of China and their influences on geographic and tissue investigated. A total of 145 fungal taxa were identified based on molecular techniques, of these 125 taxa (86.2 %) belonging to Ascomycota, 14 (9.7 %) to Basidiomycota, 5 (3.4 %) to Zygomycota, and 1 (0.7 %) to undefined fungi. The species richness and diversity of endophytic fungi were significantly affected by tissue, and were 1.2-2.5-fold higher in the branches and barks when compared to the leaves. The locality affected the species richness per tree and the shannon diversity index per tree by longitude. The endophyte assemblages were strongly shaped by locality and tissue according to partial least squares discriminant analysis. In addition, the distributions of dominant fungi at orders and genera levels differed as a function of locality and tissue. Most of the dominant taxa showed spatial heterogeneity and tissue specificity or preference and many fungal taxa with low frequency were special to one locality or one tissue.

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Taxol from Botryodiplodia theobromae (BT 115)—AN endophytic fungus of Taxus baccata

Cited by 40 publications

References 3 publications

Biologically Significant and Recently Isolated Alkaloids from Endophytic Fungi

Biologically Significant and Recently Isolated Alkaloids from Endophytic Fungi

Secondary Metabolites of Lasiodiplodia theobromae: Distribution, Chemical Diversity, Bioactivity, and Implications of Their Occurrence

Geographic and Tissue Influences on Endophytic Fungal Communities of Taxus chinensis var. mairei in China

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