Taxifolin improves disorders of glucose metabolism and water-salt metabolism in kidney via PI3K/AKT signaling pathway in metabolic syndrome rats

Gao, Liyuan; Yuan, Peipei; Zhang, Qi; Fu, Yang; Hou, Ying; Wei, Yaxin; Zheng, Xiaoke; Feng, Weisheng

doi:10.1016/j.lfs.2020.118713

Cited by 30 publications

(25 citation statements)

References 49 publications

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“…Taxifolin treatment did not induce any apparent systemic abnormalities in TgSwDI mice [ 34 ]. A previous study showed that taxifolin at 25 mg/kg (equivalent to 240 mg/60kg human) can improve homeostasis of glucose in male spontaneously hypertensive (SHR) rats [ 11 ]. The absolute bioavailability of taxifolin was reported as 0.17% in rats.…”

Section: Resultsmentioning

confidence: 99%

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Taxifolin and Sorghum Ethanol Extract Protect against Hepatic Insulin Resistance via the miR-195/IRS1/PI3K/AKT and AMPK Signalling Pathways

Lee

Jeong

et al. 2021

Antioxidants

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This study aimed to evaluate the effects of taxifolin and sorghum ethanol extract on free fatty acid (FFA)-induced hepatic insulin resistance. FFA treatment decreased glucose uptake by 16.2% compared with that in the control, whereas taxifolin and sorghum ethanol extract increased the glucose uptake. Additionally, taxifolin and sorghum ethanol extract increased the expression of p-PI3K, p-IRS1, p-AKT, p-AMPK, and p-ACC in FFA-induced hepatocytes. Furthermore, FFA treatment increased the expression of miR-195. However, compared with the FFA treatment, treatment with taxifolin and sorghum ethanol extract decreased miR-195 expression in a dose-dependent manner. Taxifolin and sorghum ethanol extract enhanced p-IRS1, p-PI3K, p-AMPK, p-AKT, and p-ACC expression by suppressing miR-195 levels in miR-195 mimic- or inhibitor-transfected cells. These results indicate that taxifolin and sorghum ethanol extract attenuate insulin resistance by regulating miR-195 expression, which suggests that taxifolin and sorghum ethanol extract may be useful antidiabetic agents.

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Section: Resultsmentioning

confidence: 99%

“…The liver is an important organ for glucose production and utilization as well as metabolic homeostasis. Insulin resistance leads to hyperglycaemia and abnormalities in the hepatic glucose output [ 11 ]. Free fatty acids (FFAs) have been shown to directly impair insulin signaling in hepatocytes [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Taxifolin and Sorghum Ethanol Extract Protect against Hepatic Insulin Resistance via the miR-195/IRS1/PI3K/AKT and AMPK Signalling Pathways

Lee

Jeong

et al. 2021

Antioxidants

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“…The ability of Ang II to elevate blood pressure is 10∼40 times powerful than adrenaline (24). Ang II raises blood pressure through multiple factors, mainly through stimulating zona glomerulosa of the adrenal gland, promoting aldosterone secretion and sodium-water retention (20,(25)(26)(27). Besides, it enhances noradrenaline release from sympathetic nerve endings (28).…”

Section: Discussionmentioning

confidence: 99%

UPLC-MS-Based Serum Metabolomics Reveals Potential Biomarkers of Ang II-Induced Hypertension in Mice

Yang

Wang

Guo

et al. 2021

Front. Cardiovasc. Med.

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Hypertension is caused by polygenic inheritance and the interaction of various environmental factors. Abnormal function of the renin-angiotensin-aldosterone system (RAAS) is closely associated with changes in blood pressure. As an essential factor in the RAAS, angiotensin II (Ang II) contributes to vasoconstriction and inflammatory responses. However, the effects of overproduction of Ang II on the whole body-metabolism have been unclear. In this study, we established a hypertensive mouse model by micro-osmotic pump perfusion of Ang II, and the maximum systolic blood pressure reached 140 mmHg after 2 weeks. By ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, the metabolites in the serum of hypertensive model and control mice were analyzed. Partial least squares discriminant analysis (PLS-DA) in both positive and negative ionization modes showed clear separation of the two groups. Perfusion of Ang II induced perturbations of multiple metabolic pathways in mice, such as steroid hormone biosynthesis and galactose metabolism. Tandem mass spectrometry revealed 40 metabolite markers with potential diagnostic value for hypertension. Our data indicate that non-targeted metabolomics can reveal biochemical pathways associated with Ang II-induced hypertension. Although researches about the clinical use of these metabolites as potential biomarkers in hypertension is still needed, the current study improves the understanding of systemic metabolic response to sustained release of Ang II in hypertensive mice, providing a new panel of biomarkers that may be used to predict blood pressure fluctuations in the early stages of hypertension.

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“…Their results showed that A. niger and A. tubingensis produced eriodictyol, while A. japonicus and A. aculeatus produced taxifolin and catechin. These phenolic compounds have several health benefits: eriodictyol is a flavonoid with broad biological and pharmacological effects [231], including anti-inflammatory effect in osteoarthritis [232], cardioprotective effect [233], control of blood vessels permeability [234] and anti-allergic effect [235]; taxifolin is also a flavonoid with biological activities at different levels, showing antioxidant [236], antibacterial, anti-inflammatory [237] and antiviral [238] activities, improving microcirculation and regulating immunity, being used for treatment of atherosclerosis, dyslipidemia, cardiovascular diseases and other chronic diseases [239,240]; catechin, again in the class of flavonoids, has proven beneficial in cardiovascular health and showing several effects on the human body [241], like antioxidant [242], antihypertensive [243], anti-inflammatory [244], antiproliferative [245] and anti-hyperlipidemic [246].…”

Section: Health Effects Of Fermented Apple Productsmentioning

confidence: 99%

Apple Fermented Products: An Overview of Technology, Properties and Health Effects

et al. 2021

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As an easily adapted culture, with overloaded production in some parts of the globe, apples and their by-products are being redirected to pharmaceutical, canning and beverages industries, both alcoholic and non-alcoholic. Fermentation is generally considered to increase the bioavailability of bioactive compounds found in apple, by impacting, through a high degree of changes, the product’s properties, including composition and health-promoting attributes, as well as their sensory profile. Probiotic apple beverages and apple vinegar are generally considered as safe and healthy products by the consumers. Recently, contributions to human health, both in vivo and in vitro studies, of non-alcoholic fermented apple-based products have been described. This review highlighted the advances in the process optimization of apple-based products considering vinegar, cider, pomace, probiotic beverages and spirits’ technologies. The different processing impacts on physical-chemical, nutritional and sensory profiles of these products are also presented. Additionally, the harmful effects of toxic compounds and strategies to limit their content in cider and apple spirits are illustrated. New trends of fermented apple-based products applicability in tangential industries are summarized.

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Taxifolin improves disorders of glucose metabolism and water-salt metabolism in kidney via PI3K/AKT signaling pathway in metabolic syndrome rats

Cited by 30 publications

References 49 publications

Taxifolin and Sorghum Ethanol Extract Protect against Hepatic Insulin Resistance via the miR-195/IRS1/PI3K/AKT and AMPK Signalling Pathways

Taxifolin and Sorghum Ethanol Extract Protect against Hepatic Insulin Resistance via the miR-195/IRS1/PI3K/AKT and AMPK Signalling Pathways

UPLC-MS-Based Serum Metabolomics Reveals Potential Biomarkers of Ang II-Induced Hypertension in Mice

Apple Fermented Products: An Overview of Technology, Properties and Health Effects

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