Taxane-induced scleroderma

Itoh, Munenari; Yanaba, Koichi; Kobayashi, Tadashi; Nakagawa, Hidemi

doi:10.1111/j.1365-2133.2006.07597.x

Cited by 55 publications

(60 citation statements)

References 23 publications

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“…However, clinical course of our case suggests that DOC may play more important role in activity of dermatomyositis than ovarian cancer. It is speculated that cytokines like tumor necrosis factor (TNF)-α may play an important role in taxane-induced scleroderma [1]. We speculated similar mechanism: other cytokines by taxane may lead to the onset of dermatomyositis.…”

Section: Discussionmentioning

confidence: 92%

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Dermatomyositis Associated with Docetaxel Use in the Treatment for Ovarian Cancer

Ito¹,

Hamada²,

Katayama³

et al. 2017

CRCM

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A 50-year-old woman presented with a 1-week history of rash on the face and hands and difficulty when rising from a sitting position. She underwent an exploratory laparotomy for ovarian cancer 8 months ago. Three months ago, she underwent total hysterectomy, adnexectomy, and retroperitoneal lymph node dissection. Docetaxel and carboplatin were started and administered twice. Physical examination revealed periorbital edema with a purplish appearance; Erythematous lesions on radiodorsal aspects of the proximal interphalangeal and metacarpophalangeal joints were seen. We diagnosed as dermatomyositis on the basis of clinical findings. Interview demonstrated that such rashes were enhanced 1 week after chemotherapy, and got better through following one week. Cutaneous and muscular symptoms got worse two months after her initial visit. Myotonia was found in electromyography, and high density areas on both femoral regions and lower thighs were observed by MRI of skeletal muscle. Scleroderma-like lesions are known as an adverse effect to taxane. In addition, three cases of dermatomyositis due to taxane were reported in Japan. Since dermatomyositis was regarded as one of paraneoplastic syndrome generally, it was not considered as drug-induced. However, clinical course of our case suggests that docetaxel may play more important role in activity of dermatomyositis than ovarian cancer. Seeing patients treated with taxane, therefore, we have to be careful for symptoms suggestive of autoimmune diseases: not only scleroderma but dermatomyositis.

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Section: Discussionmentioning

confidence: 92%

“…gastrointestinal symptoms, myelosuppression, and general fatigue, etc. In addition, scleroderma-like lesions can be occurred in patients with taxane treatment: 13 cases were collected in Japan [1] [2].…”

Section: Introductionmentioning

confidence: 99%

Dermatomyositis Associated with Docetaxel Use in the Treatment for Ovarian Cancer

Ito¹,

Hamada²,

Katayama³

et al. 2017

CRCM

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“…37 Several studies however indicate the severity of scleroderma is an important predictive factor 40 . Finally apart from radiotherapy, chemotherapy especially with docetaxel and paclitaxel has been reported to occasionally induce scleroderma 41,42,43,44 .…”

Section: Pathophysiologymentioning

confidence: 99%

Scleroderma and Breast Cancer

Michalinos¹,

Kontos²,

Fentiman³

2011

Breast Cancer - Carcinogenesis, Cell Growth and Signalling Pathways

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“…Candidate initiating agents include vinyl chloride, epoxy resins, pesticides, and a number o f o rg a n i c s o l v e n t s u s e d i n p a i n t s . Chemotherapeutic agents including taxanes have also been linked to development of scleroderma that may resemble that triggered by these other agents (16).…”

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confidence: 99%

Systemic Sclerosis – case report

Alebiosu¹,

Kebede²,

James³

et al. 2018

Research Journal of Health Sciences

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A case of Systemic Sclerosis is hereby reported, with brief review of literature emphasizing the clinical characteristics and management. Systemic Sclerosis is a connective tissue disorder affecting the skin, blood vessel, and visceral organs. Data relating to the occurrence of scleroderma is sparse or underreported in Liberia. This is a case report of a patient suffering from scleroderma seen at the Jackson F. Doe Regional Referral Hospital, Tappita, Nimba County, Liberia in May, 2018. The goal was to document the clinical occurrence of scleroderma in Liberia. Literature was reviewed using key words including scleroderma, sclerosis, Liberia, West Africa. Data bases searched were AJOL and Pubmed. Clinical manifestations of systemic scleroderma arise from the diffuse deposition of collagen in the skin and visceral organs coupled with vascular injury and immunologic abnormalities. The skin becomes taut resulting in claw like appearance of fingers and a mask like appearance of the face. There are associated orofacial changes resulting in decrease in facial profile, rigidity of tongue and microstomia. Keywords

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Taxane-induced scleroderma

Cited by 55 publications

References 23 publications

Dermatomyositis Associated with Docetaxel Use in the Treatment for Ovarian Cancer

Dermatomyositis Associated with Docetaxel Use in the Treatment for Ovarian Cancer

Scleroderma and Breast Cancer

Systemic Sclerosis – case report

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