Tautomérisation du méthyl-2-indolénine N-oxyde en solution

Regioselective One-Pot Bromination of Aromatic Amines1

“…The bromination of aminonaphthalenes shows that the steric argument may be too simplistic. While 2-aminonaphthalene (entry 8) gave a 91% yield of 1-bromo-2-aminonaphthalene, 17 1-aminonaphthalene (entry 7) gave only a 40% yield of 4-bromo-1-aminonaphthalene. 18 Although the "para" position is blocked in entry 8, there are two ortho positions, with bromination at C 1 favored.…”

In Situ Generated Palladium on Aluminum Phosphate as Catalytic System for the Preparation of β,β-Diarylated Olefins by Matsuda–Heck Reaction

“…The product was obtained as yellow solid: 91%, 1.88 g; mp: 72.5 °C (lit. mp 71–73 °C); 1 H NMR (500 MHz, CDCl 3 , ppm) δ 8.12 (d, 3 J HH = 15.8 Hz, 1H), 8.04 (d, 3 J HH = 8.0 Hz, 1H), 7.68–7.65 (m, 1H), 7.64 (d, 3 J HH = 8.0 Hz, 1H), 7.57–7.53 (m, 1H), 6.37 (d, 3 J HH = 15.8 Hz, 1H), 6.84 (s, 3H); 13 C NMR (125 MHz, CDCl 3 , ppm) δ 165.17, 147.31, 139.12, 132.49, 129.54, 129.29, 128.10, 123.89, 121.86, 50.99; IR: 2956, 1718, 1520, 1345, 1332, 1292, 1208, 1196, 1180, 975, 756; ESI-MS m / z (Intensity): 208 [MH + ] (19), 176 (100).…”

Rh(III)-Catalyzed C–H Cyclization of Arylnitrones with Diazo Compounds: Access to 3-Carboxylate SubstitutedN-Hydroxyindoles

“…In particular, N -hydroxyindole derivatives have received much interest recently because of their unique structural motif and various biological activities, such as antibiotic, antiproliferative, and platelet aggregation inhibitory activities (Figure ). Despite their pharmacological significance, only a few methods for the synthesis of these N -hydroxyindole derivatives have been reported . Therefore, it is desired to develop highly efficient methods to directly access various N -hydroxyindole derivatives.…”