Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini

Abstract

Malo A, Krüger B, Seyhun E, Schäfer C, Hoffmann RT, Göke B, Kubisch CH. Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini.

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis

“…On the other hand, in endocrine pancreatic cells TUDCA was a useful tool to reduce ER stress (31). We tested this bile salt derivate with ER chaperone-like characteristics in exocrine acinar cells, thereby reducing ER stress, trypsin activation, and apoptosis (35).…”

“…Recently, we have shown that tauroursodeoxycholic acid (TUDCA), a bile salt with ER chaperone-like properties, reduced hallmarks of acinar cell overstimulation and ER stress in isolated rat acinar cells in an in vitro system (35).…”

Tauroursodeoxycholic acid inhibits TNF-α-induced lipolysis in 3T3-L1 adipocytes via the IRE-JNK-perilipin-A signaling pathway

“…Based on previous literature, and a previous experiment (data not shown), the present study selected to treat cells with 1 mmol/l TUDCA for 3 h in vitro to ensure cell survival (15). The present study demonstrated that glycerin content in the TUDCA+TNF-α group was reduced significantly, and that dispersal of lipid droplets in the TUDCA+TNF-α group was reduced, compared with the TNF-α group.…”

Endoplasmic reticulum stress as a novel target to ameliorate epithelial-to-mesenchymal transition and apoptosis of human peritoneal mesothelial cells

“…TUDCA, an endogenous bile acid known to attenuate ER stress, 39,40 blocked the TGF-β1-induced expression of GRP78/94 and ATF6 (Figure 7b). TUDCA also inhibited XBP-1 splicing induced by TM or TG.…”