Tauroursodeoxycholic Acid Preservation of Photoreceptor Structure and Function in the<i>rd10</i>Mouse through Postnatal Day 30

Phillips, M.; Walker, Tiffany; Choi, Hwa-Jung; Faulkner, Amanda E.; Kim, Moon K.; Sidney, Sheree S.; Boyd, Amber P.; Nickerson, John M.; Boatright, Jeffrey H; Pardue, Machelle T.

doi:10.1167/iovs.07-1012

Cited by 84 publications

(95 citation statements)

References 38 publications

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“…Impressively, it has been recently shown that TUDCA preserves photoreceptor structure and function in the rd10 retinitis pigmentosa mouse model through postnatal day 30 ( 134 ). TUDCA was able to preserve rods and cones through postnatal day 30, the stage at which photoreceptor cell loss peaks.…”

Section: Discussionmentioning

confidence: 98%

Bile acids: regulation of apoptosis by ursodeoxycholic acid

Amaral

Viana

Ramalho

et al. 2009

Journal of Lipid Research

294

247

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Section: Discussionmentioning

confidence: 98%

Bile acids: regulation of apoptosis by ursodeoxycholic acid

Amaral

Viana

Ramalho

et al. 2009

Journal of Lipid Research

294

247

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“…However, in models in which degeneration progresses more slowly than in the rd10 mouse, greater sprouting of cell processes is observed, mainly from bipolar or horizontal cells (Claes et al, 2004;Cuenca et al, 2004;Haverkamp et al, 2006), which may difficult the complete recovery of the normal retina structure even if the therapy were effective. In addition to these arguments, the rd10 model of retinal degeneration has recently been used with success to test the effects of different therapeutic approaches (Otani et al, 2004;Rex et al, 2004;Boatright et al, 2006;Komeima et al, 2007;Phillips et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Functional and structural modifications during retinal degeneration in the rd10 mouse

et al. 2008

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Mouse models of retinal degeneration are useful tools to study therapeutic approaches for patients affected by hereditary retinal dystrophies. We have studied degeneration in the rd10 mice both by immunocytochemistry and TUNEL-labeling of retinal cells, and through electrophysiological recordings. The cell degeneration in the retina of rd10 mice produced appreciable morphological changes in rod and cone cells by P20. Retinal cell death is clearly observed in the central retina and it peaked at P25 when there were 800 TUNEL-positive cells per mm(2). In the central retina, only one row of photoreceptors remained in the outer nuclear layer by P40 and there was a remarkable deterioration of bipolar cell dendrites postsynaptic to photoreceptors. The axon terminals of bipolar cells also underwent atrophy and the inner retina was subject to further changes, including a reduction and disorganization of AII amacrine cell population. Glutamate sensitivity was tested in rod bipolar cells with the single cell patch-clamp technique in slice preparations, although at P60 no significant differences were observed with age-matched controls. Thus, we conclude that rod and cone degeneration in the rd10 mouse model is followed by deterioration of their postsynaptic cells and the cells in the inner retina. However, the functional preservation of receptors for photoreceptor transmission in bipolar cells may open new therapeutic possibilities.

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“…Synthetic TUDCA has been shown to exhibit antiapoptotic properties in neurodegenerative diseases, including those affecting the retina. Systemic administration of TUDCA has been demonstrated to slow retinal degeneration in both the rd10 autosomal recessive RP mouse model (Boatright et al, 2006;Drack et al, 2012;Oveson et al, 2011;Phillips et al, 2008) and in a LIRD mouse model (Boatright et al, 2006;Oveson et al, 2011). In these two retinal degeneration models, TUDCA-treated animals were shown to maintain better visual function, thicker ONL and better preservation of outer segments than untreated animals.…”

Section: Tauroursodeoxycholic Acid (Tudca)mentioning

confidence: 99%