Tauroursodeoxycholic acid improves glucose tolerance and reduces adiposity in normal protein and malnourished mice fed a high-fat diet

Araújo, Thiago dos Reis; Muniz, Mariana Roberta Rodrigues; Alves, Bruna Lourençoni; Santos, Lohanna Monali Barreto dos; Bonfim, Maressa Fernandes; Silva, Joel Alves da; Vettorazzi, Jean Franciesco; Zoppi, Cláudio C.; Carneiro, Everardo M.

doi:10.1016/j.foodres.2022.111331

Cited by 14 publications

(8 citation statements)

References 54 publications

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“…It is worth noting that they are more critical when we use the C‐T‐D network showing them as GCA degree=56 and TCA degree=50. However, many clinical studies have proved that TUDCA and UDCA can effectively regulate blood lipids [31] . We performed molecular docking validation on all components except taurine, and all docking results showed high affinity.…”

Section: Discussionmentioning

confidence: 98%

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In Vivo and Network Pharmacological Studies of Natural Bear Bile Powder Against Hyperlipidemia

Wang,

Qin,

Tian

et al. 2023

ChemistrySelect

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Natural bear bile powder (NBBP), a traditional Chinese medicine, has been clinically used to treat liver dysfunction, cardiovascular and cerebrovascular diseases. Recently it has been proved that NBBP has a good effect on regulating lipid disorders. However, the active ingredients and the anti‐hyperlipidemic effects are unclear. The high‐fat diet (HFD) induced hyperlipidemic model rats were treated with NBBP for 4 weeks and were examined for, lipid profile, liver function parameters, hepatic antioxidant status and histopathology of liver, epididymal adipose tissues. The NBBP treatment effectively improved serum lipid levels and normalized antioxidant status. A total of 16 constituents of NBBP were charactered via UHPLC‐Q‐TOF‐HRMS. We screened eight potentially active compounds and corresponded to 75 anti‐hyperlipidemic target proteins. PPI analysis showed that ALB, TNF, EGFE, PPARG, and PPARA are core proteins. Pathway enrichment analysis showed that NBBP might treat hyperlipidemia (HLP) by regulating a series of signaling pathways involving immune system, inflammatory response, and metabolism. Molecular docking revealed that gene had high affinities to NBBP compounds. In conclusion, UHPLC‐Q‐TOF‐HRMS analysis, network pharmacology, and in vivo experiments in this study provided essential references for revealing the potential mechanism of NBBP in the prevention and treatment of HLP.

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Section: Discussionmentioning

confidence: 98%

“…However, many clinical studies have proved that TUDCA and UDCA can effectively regulate blood lipids. [31] We performed molecular docking validation on all components ChemistrySelect except taurine, and all docking results showed high affinity. ALB, TNF, EGFR, PPARG and PPARA were selected as protein targets for molecular docking.…”

Section: Discussionmentioning

confidence: 99%

In Vivo and Network Pharmacological Studies of Natural Bear Bile Powder Against Hyperlipidemia

Wang,

Qin,

Tian

et al. 2023

ChemistrySelect

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“…TUDCA was recently demonstrated to be an important mediator of beneficial metabolic effects on diet-induced obesity models, as by activating FXR and TGR5, taurine-conjugated BAs can improve glucose homeostasis, lipid metabolism and BAT thermogenesis ( 81 , 82 ).…”

Section: Actions Of Tudca In Adipositymentioning

confidence: 99%

Insights by which TUDCA is a potential therapy against adiposity

et al. 2023

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Adipose tissue is an organ with metabolic and endocrine activity. White, brown and ectopic adipose tissues have different structure, location, and function. Adipose tissue regulates energy homeostasis, providing energy in nutrient-deficient conditions and storing it in high-supply conditions. To attend to the high demand for energy storage during obesity, the adipose tissue undergoes morphological, functional and molecular changes. Endoplasmic reticulum (ER) stress has been evidenced as a molecular hallmark of metabolic disorders. In this sense, the ER stress inhibitor tauroursodeoxycholic acid (TUDCA), a bile acid conjugated to taurine with chemical chaperone activity, has emerged as a therapeutic strategy to minimize adipose tissue dysfunction and metabolic alterations associated with obesity. In this review, we highlight the effects of TUDCA and receptors TGR5 and FXR on adipose tissue in the setting of obesity. TUDCA has been demonstrated to limit metabolic disturbs associated to obesity by inhibiting ER stress, inflammation, and apoptosis in adipocytes. The beneficial effect of TUDCA on perivascular adipose tissue (PVAT) function and adiponectin release may be related to cardiovascular protection in obesity, although more studies are needed to clarify the mechanisms. Therefore, TUDCA has emerged as a potential therapeutic strategy for obesity and comorbidities.

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“…Altering the BA pool by increasing microbes with 7α-dehydroxylation in gut microbes improved the phenotype of obese mice by increasing non-12OH-BAs(TCDCA, TUDCA) and decreasing 12OH-BAs(TCA). It was shown that taurochenodeoxycholic acid (TCDCA) induced the expression of UCP1, PGC1α, and Dio2 in WAT and BAT, while TCA had no significant effect on energy metabolism in adipose tissue (Dos Reis Araujo et al, 2022). Non-12OH BA improved the energy metabolism of white and brown fat through TGR5mediated activation of BAT and upregulation of UCP1 expression.…”

Section: Secondary Bile Acids Promote Brown Fat Activation To Improve...mentioning

confidence: 99%

Modulation of adipose tissue metabolism by microbial-derived metabolites

et al. 2022

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Obesity and its complications, including type 2 diabetes, cardiovascular disease, and certain cancers, have posed a significant burden on health and healthcare systems over the years due to their high prevalence and incidence. Gut microbial derivatives are necessary for the regulation of energy metabolism and host immunity, as well as for maintaining homeostasis of the intestinal environment. Gut flora metabolites may be a link between gut microbes and diseases, such as obesity, and help understand why alterations in the microbiota can influence the pathophysiology of human disease. This is supported by emerging evidence that microbial-derived metabolites, such as short-chain fatty acids, bile acids, tryptophan, trimethylamine-N-oxide, and lipopolysaccharides, can be beneficial or detrimental to the host by affecting organs outside the gut, including adipose tissue. Adipose tissue is the largest lipid storage organ in the body and an essential endocrine organ that plays an indispensable role in the regulation of lipid storage, metabolism, and energy balance. Adipose tissue metabolism includes adipocyte metabolism (lipogenesis and lipolysis), thermogenesis, and adipose tissue metabolic maladaptation. Adipose tissue dysfunction causes the development of metabolic diseases, such as obesity. Here, we review the current understanding of how these microbial metabolites are produced and discuss both established mechanisms and the most recent effects of microbial products on host adipose tissue metabolism. We aimed to identify novel therapeutic targets or strategies for the prevention and treatment of obesity and its complications.

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Tauroursodeoxycholic acid improves glucose tolerance and reduces adiposity in normal protein and malnourished mice fed a high-fat diet

Cited by 14 publications

References 54 publications

In Vivo and Network Pharmacological Studies of Natural Bear Bile Powder Against Hyperlipidemia

In Vivo and Network Pharmacological Studies of Natural Bear Bile Powder Against Hyperlipidemia

Insights by which TUDCA is a potential therapy against adiposity

Modulation of adipose tissue metabolism by microbial-derived metabolites

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