Taurolidine-citrate lock solution (TauroLock) significantly reduces CVAD-associated grampositive infections in pediatric cancer patients

Simon, Arne; Ammann, Roland A.; Wiszniewsky, Gertrud; Bode, Udo; Fleischhack, Gudrun; Besuden, Mette

doi:10.1186/1471-2334-8-102

Cited by 82 publications

(71 citation statements)

References 35 publications

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“…Taurolidine-citrate locks have been compared with heparin locks and shown to reduce rates of bloodstream infection. 521 Restoration of CVAD patency has usually involved intermittent bolus dosing of a variety of agents, with failure to restore patency being defi ned as the CVAD removal and replacement rate. Primary prophylaxis to avoid large-vessel thrombosis around the CVAD usually involves systemic anticoagulation and needs to be considered separately.…”

Section: For Children With Fi Rst Vte Secondary To Structural Venous mentioning

confidence: 99%

Antithrombotic Therapy in Neonates and Children

Monagle

Chan

Goldenberg

et al. 2012

Chest

1,244

559

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Section: For Children With Fi Rst Vte Secondary To Structural Venous mentioning

confidence: 99%

Antithrombotic Therapy in Neonates and Children

Monagle

Chan

Goldenberg

et al. 2012

Chest

1,244

559

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“…Guerraoui et al 124 reported resistant strains of S. epidermidis after prolonged use of gentamicin locks for prophylaxis in permanent haemodialysis catheters. Finally, in a before-after study comparing taurolidine with heparin saline locks in children with cancer, Simon et al 100 reported a reduction in CVC-associated infection with staphylococci and an increase in CVC-associated infection with E. coli (10/27 in the taurolodine group vs 4/31 in the control group; odds ratio for E. coli occurrence 3.97, 95% CI 1.12 to 13.93).…”

Section: Resultsmentioning

confidence: 99%

“…72,[83][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98][99] The remaining six studies included citrate or taurolidine. [100][101][102][103][104][105]123 Most studies were conducted in patients undergoing haemodialysis (n = 17), but there were four studies in children with cancer. [85][86][87]100 No studies compared locks in adults or children receiving parenteral nutrition.…”

Section: Resultsmentioning

confidence: 99%

“…[100][101][102][103][104][105]123 Most studies were conducted in patients undergoing haemodialysis (n = 17), but there were four studies in children with cancer. [85][86][87]100 No studies compared locks in adults or children receiving parenteral nutrition.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, the systematic review found relatively few studies in children with cancer (four studies). [85][86][87]100 None of the trials involved children undergoing care in a UK cancer centre. A large proportion of the trials of use of antimicrobial locks for prevention have involved renal patients:…”

Section: Recommendations For Researchmentioning

confidence: 99%

See 2 more Smart Citations

Accuracy of bacterial DNA testing for central venous catheter-associated bloodstream infection in children with cancer

Millar

Zhou²,

Skinner³

et al. 2011

Health Technol Assess

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