1972
DOI: 10.3109/00365527209180957
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Taurocholate Metabolism in Man

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1978
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Cited by 21 publications
(7 citation statements)
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“…White et al suggested that microbial 7-dehydroxylases are not capable of modifying conjugated bile acids . However, Stahl et al disagreed with this hypothesis, given that they detected the dehydroxylation product of taurocholic acid, taurodeoxycholate, in humans . Here, we show that 50% of bile acids are resorbed in the ileum.…”
Section: Resultscontrasting
confidence: 45%
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“…White et al suggested that microbial 7-dehydroxylases are not capable of modifying conjugated bile acids . However, Stahl et al disagreed with this hypothesis, given that they detected the dehydroxylation product of taurocholic acid, taurodeoxycholate, in humans . Here, we show that 50% of bile acids are resorbed in the ileum.…”
Section: Resultscontrasting
confidence: 45%
“…Bile acids are known to aid lipid digestion through their emulsification ability and are therefore an important part of the digestion process. They are produced in the liver, stored in the gall bladder, secreted into the duodenum, stimulated (for example, by secretin and cholecystokinine), reabsorbed, and reused in the enterohepatic circulation, which is facilitated by deconjugation, dehydrogenation, and dehydroxylation by microbes. ,, The regulation of bile acid production from cholesterol occurs via the FXR receptor, which also influences lipid and glucose metabolism. , Their activity depends not only on the amount of bile acids but also on their conjugation and hydroxylation pattern. Furthermore, bile acid receptors or the presence of nutrient transporters may be specific to different gut section sites .…”
Section: Resultsmentioning
confidence: 99%
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“…First, 2,3-BPG occurs abundantly in red blood cells, being at approximately 5 mmol L −1 [23]. Secondly, taurocholate is synthesized and excreted to bile canaliculi around periportal hepatocytes [24, 25], whereas UDP-glucuronate is biosynthesized predominantly in pericentral hepatocytes, which had a large capacity for xenobiotic detoxification [26, 27]. Our approach to analysis of metabolites at the microscopic level, serves as a powerful tool to investigate intralobular heterogeneity in metabolic systems in the liver.…”
Section: Resultsmentioning
confidence: 99%
“…The quantitative contribution of hepatic taurine conjugation to taurine utilization can be extrapolated from published data (15,19,41). Glycine is another amino acid moiety used for bile acid conjugation (18).…”
Section: Discussionmentioning
confidence: 99%