Taurochenodeoxycholic acid inhibits the proliferation and invasion of gastric cancer and induces its apoptosis

Zhang, Dongwei; Zhu, Yongfu; Su, Ya; Mu, Yu; Xu, Xiequn; Wang, Chunhua; Zhang, Shaohu; Xia, Liming

doi:10.1111/jfbc.13866

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…TCDCA inhibited gastric cancer proliferation and invasion and induced apoptosis. Traditional Chinese medicine in experimental studies offered encouraging evidence for the potential application in the blockade of tumor ( Zhang et al, 2022 ). DCA triggered apoptosis in gastric carcinoma cells by activating intrinsic mitochondrial-dependent, p53-mediatedcell death pathway ( Yang et al, 2015 ).…”

Section: The Anticancer Effect Of Natural Basmentioning

confidence: 99%

“…Furthermore, various factors, including gene mutations for the BA synthesis and transport, high-fat diets, medications, and circadian rhythm disturbances, are found to mediate the pathologies of multiple diseases that involve cholestatic liver disease, inflammatory bowel disease, diabetes, obesity, tumors, and related metabolic disorders ( Li and Chiang, 2014 ; Fiorucci et al, 2021 ; Fu et al, 2021 ; Perino et al, 2021 ; Yang et al, 2021 ; Shi et al, 2023 ). In recent years, several researches have demonstrated that BAs have antitumor properties in various cancer cell types, such as tamoxifen-resistant breast cancer ( Luu et al, 2018 ; Kovács et al, 2019 ), oral squamous cell carcinoma ( Talebian et al, 2020 ), cholangiocarcinoma ( Lee et al, 2022 ), gastric cancer ( Zhang et al, 2022 ), colon cancer ( Kim E. K. et al, 2017 ), hepatocellular carcinoma ( Fan et al, 2023 ), prostate cancer ( Lee et al, 2017 ), gallbladder cancer ( Lin et al, 2020 ; Li et al, 2022 ), neuroblastoma ( Trah et al, 2020 ) etc., by inhibiting cancer cell proliferation and migration. In addition, new BA derivatives have been synthesized in several laboratories to investigate their anticancer properties.…”

Section: Introductionmentioning

confidence: 99%

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The anticancer activity of bile acids in drug discovery and development

Li,

Zou,

Huang

et al. 2024

Front. Pharmacol.

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Bile acids (BAs) constitute essential components of cholesterol metabolites that are synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the biliary system. They play a crucial role in nutrient absorption, lipid and glucose regulation, and the maintenance of metabolic homeostasis. In additional, BAs have demonstrated the ability to attenuate disease progression such as diabetes, metabolic disorders, heart disease, and respiratory ailments. Intriguingly, recent research has offered exciting evidence to unveil their potential antitumor properties against various cancer cell types including tamoxifen-resistant breast cancer, oral squamous cell carcinoma, cholangiocarcinoma, gastric cancer, colon cancer, hepatocellular carcinoma, prostate cancer, gallbladder cancer, neuroblastoma, and others. Up to date, multiple laboratories have synthesized novel BA derivatives to develop potential drug candidates. These derivatives have exhibited the capacity to induce cell death in individual cancer cell types and display promising anti-tumor activities. This review extensively elucidates the anticancer activity of natural BAs and synthetic derivatives in cancer cells, their associated signaling pathways, and therapeutic strategies. Understanding of BAs and their derivatives activities and action mechanisms will evidently assist anticancer drug discovery and devise novel treatment.

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Section: The Anticancer Effect Of Natural Basmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The anticancer activity of bile acids in drug discovery and development

Li,

Zou,

Huang

et al. 2024

Front. Pharmacol.

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“…Many Chinese monomers inhibit tumor growth [7,8]. Drug components in natural plants cause few adverse reactions owing to their single components and thus allow for a wide range of treatments.…”

Section: Introductionmentioning

confidence: 99%

Effects and Mechanisms of Fucoxanthin from Hizikia fusiforme on Inhibiting Tongue Squamous Cell Carcinoma Proliferation via AKT/mTOR-Mediated Glycolysis

Zhang,

Liu,

Zhang

et al. 2023

Journal of Food Biochemistry

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Fucoxanthin, a natural carotenoid, contains special ene bonds and 5, 6-mono-epoxide compounds in its molecule, which has physiological activities such as anticancer, antioxidant, anti-inflammatory, antiobesity, and antidiabetic. However, the anticancer actions and underlying mechanisms of fucoxanthin on oral cancer remain to be assessed. In this study, we used tongue carcinoma (CAL-27) cells to examine the effects and underlying mechanisms of fucoxanthin derived from Hizikia fusiforme on CAL-27 proliferation. MTT assays were used to estimate fucoxanthin’s effect on the proliferative capacity of CAL-27 cells. Flow cytometry was used to examine how fucoxanthin affects apoptosis initiation and alters cell cycle progression in CAL-27 cells. Spectrophotometry was used to assess the impact of fucoxanthin on adenosine triphosphate (ATP) generation, glucose uptake, lactate production, and the enzymatic activities of pyruvate kinase and hexokinase in CAL-27 cells. Western blotting was used to investigate fucoxanthin’s impact on the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway and glycolysis-related protein expression levels in CAL-27 cells. Fucoxanthin significantly inhibited CAL-27 cell viability time- and dose-dependently p < 0.01 . Administration of fucoxanthin induced CAL-27 cell apoptosis and cell cycle arrest at the G1 phase p < 0.05 . Furthermore, fucoxanthin significantly decreased glucose uptake, lactate production, and ATP production in CAL-27 cells p < 0.01 and significantly inhibited glycolysis-related enzyme activities and protein expression levels p < 0.05 . Fucoxanthin also substantially decreased the expression levels of phosphorylated ribosomal protein S6, phosphorylated AKT, and phosphorylated mTOR p < 0.05 . In conclusion, fucoxanthin inhibited CAL-27 cell proliferation, and this mechanism may be associated with the AKT/mTOR-mediated glycolysis pathway.

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“…TCDCA is one of the main active ingredients of bear bile powder ( Shi et al, 2017 ). It has been shown that TCDCA is used to treat diseases such as astrocytic neuroinflammation ( Xu et al, 2023a ), pulmonary fibrosis ( Zhou et al, 2013 ), and gastric cancer ( Zhang et al, 2022 ), with inhibitory effects on both acute and chronic inflammation as well as modulating immune responses ( Li et al, 2019 ; Bao et al, 2021 ). Recent studies have reported that TCDCA can reduce intestinal fat transport and treat non-alcoholic fatty liver disease in mice ( Wang et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia

Cui,

Zhang,

et al. 2023

Front. Pharmacol.

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Bile acids are the main component of animal bile and are directly involved in the metabolic process of lipids in vivo. Taurochenodeoxycholic acid (TCDCA) is the primary biologically active substance in bile acids and has biological functions such as antioxidant, antipyretic, anti-inflammatory, and analgesic activities and improves immunity. In the present study, we assessed the impact of TCDCA on hyperlipidemia development in mouse models. Mice were fed a high-fat diet (HFD) to induce hyperlipidemia and orally administered different doses of TCDCA orally for 30 days. Then, indicators such as triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in mice were detected. Using HE and ORO staining techniques, the morphology of the mice’s liver tissue was detected. Based on metabolomic and lipidomic analyses, we determined the mechanism of TCDCA in treating hyperlipidemia. The results showed that TCDCA had a significant ameliorating effect on dietary hyperlipidemia. In addition, it exerted therapeutic effects through glycerophospholipid metabolism.

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Taurochenodeoxycholic acid inhibits the proliferation and invasion of gastric cancer and induces its apoptosis

Cited by 4 publications

References 23 publications

The anticancer activity of bile acids in drug discovery and development

The anticancer activity of bile acids in drug discovery and development

Effects and Mechanisms of Fucoxanthin from Hizikia fusiforme on Inhibiting Tongue Squamous Cell Carcinoma Proliferation via AKT/mTOR-Mediated Glycolysis

Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia

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