Taurine-upregulated gene 1 contributes to cancers through sponging microRNA

Zhou, Hui; Gao, Zixu; Wan, Fang

doi:10.1093/abbs/gmy156

Cited by 15 publications

(10 citation statements)

References 79 publications

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“…However, we further studied the mechanism by evaluating the possible role of miRNA sponging by MALAT1. lncRNAs mode of functioning through sponging of miRNAs is well known 23 , 24 , 27 , 28 . In our screening, which involved miRNAs documented to be targets of MALAT1 as well as some revealed by online prediction tools, the two miRNAs that clearly stood out were miR-202 and miR-34a.…”

Section: Discussionmentioning

confidence: 99%

LncRNA MALAT1 facilitates lung metastasis of osteosarcomas through miR-202 sponging

Zhang

Piao

Ding

2020

Sci Rep

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Lungs are the primary metastatic sites for osteosarcomas responsible for associated mortality. Recent data has documented role of long non-coding RNAs (lncRNAs) in proliferation and growth of osteosarcoma cells. We evaluated a role of lncRNAs in the lung metastasis of osteosarcoma with the goal of identifying a unique signature. Comparison of different lncRNAs in tumor samples from osteosarcoma with and without lung metastasis led to identification of MALAT1 as the most differentially upregulated lncRNA in the osteosarcoma patients with lung metastasis. MALAT1 was also high in osteosarcoma cells KRIB and MALAT1’s targeted downregulation in these cells led to decreased invasive potential and identification of miR-202 as the miRNA that is sponged by MALAT1. In the lung metastasis in vivo model, parental KRIB cells metastasized to lungs and such metastasis was significantly inhibited in KRIB cells with downregulated MALAT1. Ectopic miR-202 expression attenuated KRIB downregulation-mediated effects on lung metastasis. In yet another in vivo model involving parental SAOS-2 and lung-metastatic derivatives SAOS-2-LM, MALAT1 expression was found to be elevated in lung metastatic cells, which also correlated with reduced miR-202. In conclusion, MALAT1-miR-202 represents a potential lncRNA-miRNA signature that affects lung metastasis of osteosarcomas and could potentially be targeted for therapy.

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Section: Discussionmentioning

confidence: 99%

LncRNA MALAT1 facilitates lung metastasis of osteosarcomas through miR-202 sponging

Zhang

Piao

Ding

2020

Sci Rep

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“…There is increasing evidence that lncRNA can be used as a biomarker for the diagnosis and prognosis of various cancers, such as colorectal cancer, breast cancer, breast cancer, liver cancer and gastric cancer . In addition, in the study of liver metastases from colorectal cancer, it was found that lncRNA UICLM inhibits the expression of miR‐150‐5p by competitive endogenous RNA, thereby promoting liver metastasis of colorectal cancer . Long non‐coding RNA can not only regulate gene expression as a competitive endogenous RNA, but also regulate epigenetics by binding to related proteins.…”

Section: Introductionmentioning

confidence: 99%

LINC01303 functions as a competing endogenous RNA to regulate EZH2 expression by sponging miR‐101‐3p in gastric cancer

Cao

et al. 2019

J Cellular Molecular Medi

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Long non‐coding RNA (lncRNA) is one of the important regulators of many malignancies. However, the biological function and clinical significance of a large number of lncRNAs in gastric cancer remain unclear. Therefore, we analysed the TCGA data to find that LINC01303 is significantly up‐regulated in gastric cancer tissues. However, the biological function of LINC01303 in GC remains unknown. In our study, we found that the expression of LINC01303 was significantly higher in GC tissues than in adjacent tissues by real‐time quantitative PCR. We can significantly inhibit the malignant proliferation, migration and invasion of GC cells by silencing LINC01303 expression. In addition, LINC01303 knockdown can also inhibit GC growth in vivo. After the bioinformatics analysis, we found that LINC01303 can be used as a miR‐101‐3p sponge to competitively adsorb miR‐101‐3p with EZH2. Therefore, our results indicate that LINC01303 promotes the expression of EZH2 by inhibiting miR‐101‐3p activity and promotes GC progression. In summary, in this study, we demonstrated for the first time that the LINC01303/miR‐101‐3p/EZH2 axis promotes GC progression.

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“…Long non-coding RNAs (LncRNAs) are a class of RNAs with transcriptome length of over 200 nucleotides and lack of protein-coding capacity [5]. LncRNAs represent the major regulators of gene expression and participate in biological functions and cancer progression [6].…”

Section: Introductionmentioning

confidence: 99%

Regulatory mechanism of lncRNA HCP5 in nasopharyngeal carcinoma cell proliferation and apoptosis via the miR-140-5p/NPR3 axis

Huang

Deng

et al. 2020

Preprint

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Objectives Nasopharyngeal carcinoma (NPC) is malignant tumor frequently occurring in east and southeast Asia. This study investigated the underlying mechanism of lncRNA HCP5 in NPC cell proliferation and apoptosis. Methods LncRNA HCP5 expression in NPC cells and tissues was detected. SUNE-1 cells were transfected with HCP5 silencing and CNE-1 cells were transfected with overexpressing HCP5, and then cell proliferation and apoptosis were measured. Subcellular localization of HCP5 was analyzed. The binding relationship between lncRNA HCP5 and miR-140-5p, and miR-140-5p and NPR3 were predicted and verified. Expressions of miR-140-5p and NPR3 in NPC cells were detected. SUNE-1 cells and CNE-1 cells were transfected with miR-140-5p mimic, and si-HCP5-transfected SUNE-1 cells were treated with miR-140-5p inhibitor. Then the proliferation and apoptosis of NPC cells were detected. Results LncRNA HCP5 was elevated in NPC tissues and cells. HCP5 silencing suppressed NPC cell proliferation and enhanced apoptosis. HCP5 was mainly located in the cytoplasm of NPC cells. HCP5 promoted NPR3 expression by competitively binding to miR-140-5p. Overexpression of miR-140-5p weakened proliferation and facilitated apoptosis of NPC cells. miR-140-5p inhibitor partially restored the effects of HCP5 silencing on NPC cells. Conclusion LncRNA HCP5 upregulated NPR3 expression via sponging miR-140-5p, thereby suppressing NPC cell proliferation and promoting apoptosis. This study may offer new insights into NPC treatment.

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Taurine-upregulated gene 1 contributes to cancers through sponging microRNA

Cited by 15 publications

References 79 publications

LncRNA MALAT1 facilitates lung metastasis of osteosarcomas through miR-202 sponging

LncRNA MALAT1 facilitates lung metastasis of osteosarcomas through miR-202 sponging

LINC01303 functions as a competing endogenous RNA to regulate EZH2 expression by sponging miR‐101‐3p in gastric cancer

Regulatory mechanism of lncRNA HCP5 in nasopharyngeal carcinoma cell proliferation and apoptosis via the miR-140-5p/NPR3 axis

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