Taurine Targets the GluN2b-Containing NMDA Receptor Subtype

Chan, Christopher; Singh, Inderbir; Magnuson, Heather; Zohaib, Mohammad; Bakshi, Kalindi; François, Brice Le; Anazco-Ayala, Ana; Lee, Eung Jeon; Tom, Andrew; YeeMon, Kristel; Ragnauth, Andre; Friedman, Eitan; Banerjee, Sipra

doi:10.1007/978-3-319-15126-7_43

Cited by 12 publications

(7 citation statements)

References 46 publications

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“…Recently, it was reported that taurine could directly interact with NMDA receptors and significantly reduce the NMDA receptormediated component of the field potential (Chan et al, 2014(Chan et al, , 2015. These actions of taurine support our findings that neuroprotection of taurine against NMDA induced-excitotoxicity were dependent on NMDA receptors.…”

Section: Discussionsupporting

confidence: 88%

Neuroprotection of taurine against reactive oxygen species is associated with inhibiting NADPH oxidases

Zhou

Gao

Lin

et al. 2016

European Journal of Pharmacology

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Section: Discussionsupporting

confidence: 88%

Neuroprotection of taurine against reactive oxygen species is associated with inhibiting NADPH oxidases

Zhou

Gao

Lin

et al. 2016

European Journal of Pharmacology

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“…Existing evidence shows that EGF and taurine are implicated in the regulation of oxidative stress (Chen et al, 2012 ; Nagano et al, 2015 ) and activity of NMDA receptors (Chan et al, 2015 ; Tang et al, 2015 ). It is apparent that both EGF and taurine affect the formation of reactive oxidative species (Cha et al, 2000 ; Zhang et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the redox status has been shown to play a role in the regulation of NMDA receptors (Hashimoto, 2014 ). Moreover, recent studies demonstrate that both EGF and taurine influence the GluN2B subunit of NMDA receptors (Chan et al, 2015 ; Tang et al, 2015 ). Therefore, one could speculate that the elevated levels of EGF and taurine in antipsychotic-naïve FEP patients may reflect the corrupted function of NMDA receptors.…”

Section: Discussionmentioning

confidence: 99%

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Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis

et al. 2016

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This study evaluated the levels of two amino acid derivatives taurine and spermine in first-episode psychosis (FEP) patients and their response to antipsychotic treatment. The levels of taurine and spermine were significantly up-regulated in antipsychotic-naïve FEP patients compared to control subjects (CS). Treatment of FEP patients with antipsychotic drugs significantly reduced the positive symptoms of schizophrenia. This positive effect was accompanied by a significant reduction of taurine and spermine to the levels measured in CS. General linear model was used to establish associations of taurine and spermine with the levels of cytokines and growth factors, measured in our previous experiments using the same study sample. There was a strong association between taurine and epidermal growth factor (EGF). Both biomarkers significantly correlated with the disease symptoms as well as with the effectiveness of antipsychotic treatment. Accordingly one can conclude that taurine and EGF belong to the signature of FEP. Most probably they reflect altered oxidative stress and corrupted function of N-methyl-D-aspartate (NMDA) receptors in FEP.

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“…In contrast, postsynaptic NMDA receptors seem to be rather inhibited by taurine, although at substantial higher concentration in the mM range ( Chan et al, 2014 ). It was speculated that this postsynaptic inhibition is mediated via an interaction with the allosteric glycine binding site of NMDA receptors ( Chan et al, 2014 ) and depends on NR2B subunits ( Chan et al, 2015 ).…”

Section: Taurine Release Mechanisms and Taurine Receptorsmentioning

confidence: 99%

Taurine as an Essential Neuromodulator during Perinatal Cortical Development

Kilb

Fukuda

2017

Front. Cell. Neurosci.

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A variety of experimental studies demonstrated that neurotransmitters are an important factor for the development of the central nervous system, affecting neurodevelopmental events like neurogenesis, neuronal migration, programmed cell death, and differentiation. While the role of the classical neurotransmitters glutamate and gamma-aminobutyric acid (GABA) on neuronal development is well established, the aminosulfonic acid taurine has also been considered as possible neuromodulator during early neuronal development. The purpose of the present review article is to summarize the properties of taurine as neuromodulator in detail, focusing on the direct involvement of taurine on various neurodevelopmental events and the regulation of neuronal activity during early developmental epochs. The current knowledge is that taurine lacks a synaptic release mechanism but is released by volume-sensitive organic anion channels and/or a reversal of the taurine transporter. Extracellular taurine affects neurons and neuronal progenitor cells mainly via glycine, GABA(A), and GABA(B) receptors with considerable receptor and subtype-specific affinities. Taurine has been shown to directly influence neurogenesis in vitro as well as neuronal migration in vitro and in vivo. It provides a depolarizing signal for a variety of neuronal population in the immature central nervous system, thereby directly influencing neuronal activity. While in the neocortex, taurine probably enhance neuronal activity, in the immature hippocampus, a tonic taurinergic tone might be necessary to attenuate activity. In summary, taurine must be considered as an essential modulator of neurodevelopmental events, and possible adverse consequences on fetal and/or early postnatal development should be evaluated for pharmacological therapies affecting taurinergic functions.

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Taurine Targets the GluN2b-Containing NMDA Receptor Subtype

Cited by 12 publications

References 46 publications

Neuroprotection of taurine against reactive oxygen species is associated with inhibiting NADPH oxidases

Neuroprotection of taurine against reactive oxygen species is associated with inhibiting NADPH oxidases

Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis

Taurine as an Essential Neuromodulator during Perinatal Cortical Development

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