Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure

Ahmadian, Mehdi; Roshan, Valiollah Dabidi; Aslani, Elaheh; Stannard, Stephen R.

doi:10.1177/1753944717711138

Cited by 39 publications

(27 citation statements)

References 28 publications

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“…Further clinical studies demonstrated that patients with type-2 diabetes following supplementation of taurine (500 mg/3 times/day for 2 weeks) also attenuated vascular dysfunction assessed by lower FMD (flow-mediated dilatation), indicating that taurine alone reverses endothelial dysfunction, which is the primary path to atherosclerosis. However, the other CVD parameters, such as heart rate, ejection rate, or inflammation (detected by hsCRP), were not found in these patients [215], unlike those with heart failure [207]. Supplementing type-2 diabetic patients with 1500 mg/day taurine for 90 days was shown to lower arachidonic acid levels compared to control subjects.…”

Section: Taurine As a Therapeutic In Cardiovascular Disease: Human CLmentioning

confidence: 74%

“…In fact, exercise in HF patients has been shown to improve circulating angiogenic cells [206]. In addition, taurine supplementation (500 mg/3 times/day for 2 weeks) in patients with HF significantly reduced total cholesterol, triglyceride levels, high-density lipoprotein cholesterol, and inflammatory biomarker hsCRP (high sensitivity C reactive protein) levels, both prior to and after exercise [207]. This suggests that taurine supplementation may exert a beneficial impact on the cardiovascular system in patients with CVD complications.…”

Section: Taurine As a Therapeutic In Cardiovascular Disease: Human CLmentioning

confidence: 99%

“…Subject Dose/Time Outcome [205,207] Heart Failure 1500 mg/day, 2 weeks Improved exercise capacity, reduced TC/HDL-c, and reduced hsCRP [208] Chronic Heart Failure 3000 mg/day, 30-45 days Decreased left ventricular end-diastolic volume with left ventricular dysfunction before revascularization [209] Chronic Heart Failure 3000 mg/day, 6 CBS, cystathionine β synthase deficiency; FBS, fasting blood sugar; HDL-c, high-density lipid cholesterol; hsCRP, high-sensitivity C-reactive protein; LDL-c, low-density lipid cholesterol; TC, total cholesterol.…”

Section: Refmentioning

confidence: 99%

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The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

et al. 2020

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Taurine is a non-protein amino acid that is expressed in the majority of animal tissues. With its unique sulfonic acid makeup, taurine influences cellular functions, including osmoregulation, antioxidation, ion movement modulation, and conjugation of bile acids. Taurine exerts anti-inflammatory effects that improve diabetes and has shown benefits to the cardiovascular system, possibly by inhibition of the renin angiotensin system. The beneficial effects of taurine are reviewed.

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Section: Taurine As a Therapeutic In Cardiovascular Disease: Human CLmentioning

confidence: 74%

Section: Taurine As a Therapeutic In Cardiovascular Disease: Human CLmentioning

confidence: 99%

Section: Refmentioning

confidence: 99%

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The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

et al. 2020

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“…In a human study that included smokers, it was found that Tau was positively associated with endothelial functioning ( 206 ). Recently, it was shown that Tau exerts anti-atherogenic as well as anti-inflammatory effects (lowering of C-reactive protein (CRP) and platelets) in patients with HF and a left ventricular ejection fraction of <50% ( 207 ). Tau and Mg supplementation significantly increased the endothelial progenitor cell (EPC) colony numbers (EPCs repair endothelial damage to prevent CVDs) and significantly decreased free radical levels and thiobarbituric acid scores in healthy men.…”

Section: Conditionally Essential Aas In Atherosclerosismentioning

confidence: 99%

Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes

et al. 2020

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Cardiovascular disease is the leading global health concern and responsible for more deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory disease in the arterial wall, which underpins several types of cardiovascular disease. It has emerged that a strong relationship exists between alterations in amino acid (AA) metabolism and the development of atherosclerosis. Recent studies have reported positive correlations between levels of branched-chain amino acids (BCAAs) such as leucine, valine, and isoleucine in plasma and the occurrence of metabolic disturbances. Elevated serum levels of BCAAs indicate a high cardiometabolic risk. Thus, BCAAs may also impact atherosclerosis prevention and offer a novel therapeutic strategy for specific individuals at risk of coronary events. The metabolism of AAs, such as L-arginine, homoarginine, and L-tryptophan, is recognized as a critical regulator of vascular homeostasis. Dietary intake of homoarginine, taurine, and glycine can improve atherosclerosis by endothelium remodeling. Available data also suggest that the regulation of AA metabolism by indoleamine 2,3-dioxygenase (IDO) and arginases 1 and 2 are mediated through various immunological signals and that immunosuppressive AA metabolizing enzymes are promising therapeutic targets against atherosclerosis. Further clinical studies and basic studies that make use of animal models are required. Here we review recent data examining links between AA metabolism and the development of atherosclerosis.

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“…As a potential pharmacological agent, its role against oxidative stress and inflammation has been investigated by different studies. It protects against various diseases and disorders in different organ systems such as the integumentary, cardiovascular, respiratory, muscular, skeletal, circulatory and endocrine systems [[6], [7], [8], [9], [10], [11], [12]].…”

Section: Introductionmentioning

confidence: 99%

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

et al. 2019

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Taurine is a sulfur-containing amino acid and known as semi-essential in mammals and is produced chiefly by the liver and kidney. It presents in different organs, including retina, brain, heart and placenta and demonstrates extensive physiological activities within the body. In the several disease models, it attenuates inflammation- and oxidative stress-mediated injuries. Taurine also modulates ER stress, Ca 2+ homeostasis and neuronal activity at the molecular level as part of its broader roles. Different cellular processes such as energy metabolism, gene expression, osmosis and quality control of protein are regulated by taurine. In addition, taurine displays potential ameliorating effects against different neurological disorders such as neurodegenerative diseases, stroke, epilepsy and diabetic neuropathy and protects against injuries and toxicities of the nervous system. Several findings demonstrate its therapeutic role against neurodevelopmental disorders, including Angelman syndrome, Fragile X syndrome, sleep-wake disorders, neural tube defects and attention-deficit hyperactivity disorder. Considering current biopharmaceutical limitations, developing novel delivery approaches and new derivatives and precursors of taurine may be an attractive option for treating neurological disorders. Herein, we present an overview on the therapeutic potential of taurine against neurological disorders and highlight clinical studies and its molecular mechanistic roles. This article also addresses the neuropharmacological potential of taurine analogs.

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Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure

Abstract: our results suggest that 2 weeks of oral taurine supplementation increases the taurine levels and has anti-atherogenic and anti-inflammatory effects prior to and following incremental exercise in HF patients.

Cited by 39 publications

References 28 publications

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

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