Taurine reduction associated with heart dysfunction after real-world PM2.5 exposure in aged mice

Qi, Zenghua; Yang, Chun; Liao, Xiaoliang; Zhao, Lifang; Liang, Xiaoping; Su, Yu‐Ping; Chen, Zhi Feng; Li, Ruijin; Dong, Chuan; Cai, Zongwei

doi:10.1016/j.scitotenv.2021.146866

Cited by 12 publications

(15 citation statements)

References 47 publications

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“…Particulate matter in HAP is likely to cause oxidative stress, inflammation, abnormal lipid metabolism, and thrombosis in circulation, which will adversely affect endothelial function, and then induce atherosclerosis, the main pathological process behind IHD. [25][26][27][28][29] Exposure to air pollution was associated with higher blood pressure [30][31][32] and an imbalance of the autonomic control of the heart and reduced heart rate variability, [33][34][35] both of which were implicated as potential mediators of cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Global magnitude and long‐term trend of ischemic heart disease burden attributed to household air pollution from solid fuels in 204 countries and territories, 1990–2019

et al. 2022

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Understanding the spatiotemporal variation in the household air pollution from solid fuels (HAP)-related ischemic heart disease (IHD) burden on a global scale from 1990 to 2019 is essential to reduce IHD burden, as well as control HAP exposure. Based on the Global Burden of Disease Study 2019, the numbers and age-standardized rates of IHD mortality and disability-adjusted life years (DALYs) (ASMR and ASDR) attributed to HAP were analyzed by sex and age at global, regional, and national levels. The estimated annual percentage change was calculated to evaluate the temporal trend in burden rates. In 2019, IHD attributed to HAP resulted in 511 170 deaths and 13.18 million DALYs globally.The corresponding ASMR and ASDR were higher in males, increased with age peaking at about 80-94 years, and varied greatly across the world. Despite a remarkable decline in HAP-related IHD was achieved across the world over the past decades, an undesirable increase could be observed in some low-income but with high-burden countries. Sustained and comprehensive efforts are needed to control HAP and reduce the IHD burden, especially in countries and territories with a heavy or increasing burden, such as the Solomon Islands,

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Section: Discussionmentioning

confidence: 99%

Global magnitude and long‐term trend of ischemic heart disease burden attributed to household air pollution from solid fuels in 204 countries and territories, 1990–2019

et al. 2022

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“…Some studies recently also found that elevated PM 2.5 exposure was associated with both decreased HRV and increased HR, focusing on daily routines or a certain period such as cycling [ 15 , 16 , 17 , 29 , 30 , 31 ]. Moreover, the associations between exposure to PM 2.5 and increased HR were found in mice [ 32 , 33 , 34 ]. Therefore, HR is a useful indicator for autonomic nervous system, with increased HR indicating the adverse impacts from air pollutants such as PM 2.5 .…”

Section: Discussionmentioning

confidence: 99%

Demonstrating the Applicability of Smartwatches in PM2.5 Health Impact Assessment

Tsou

Lung

Cheng

2021

Sensors

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Smartwatches are being increasingly used in research to monitor heart rate (HR). However, it is debatable whether the data from smartwatches are of high enough quality to be applied in assessing the health impacts of air pollutants. The objective of this study was to assess whether smartwatches are useful complements to certified medical devices for assessing PM2.5 health impacts. Smartwatches and medical devices were used to measure HR for 7 and 2 days consecutively, respectively, for 49 subjects in 2020 in Taiwan. Their associations with PM2.5 from low-cost sensing devices were assessed. Good correlations in HR were found between smartwatches and certified medical devices (rs > 0.6, except for exercise, commuting, and worshipping). The health damage coefficients obtained from smartwatches (0.282% increase per 10 μg/m3 increase in PM2.5) showed the same direction, with a difference of only 8.74% in magnitude compared to those obtained from certified medical devices. Additionally, with large sample sizes, the health impacts during high-intensity activities were assessed. Our work demonstrates that smartwatches are useful complements to certified medical devices in PM2.5 health assessment, which can be replicated in developing countries.

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“…At the end of exposure, the heart function of mice was examined by echocardiography. The procedures used for the experiments are described in our previous work …”

Section: Methodsmentioning

confidence: 99%

Contribution and Effects of PM_2.5-Bound Lead to the Cardiovascular Risk of Workers in a Non-Ferrous Metal Smelting Area Considering Chemical Speciation and Bioavailability

Zhao

Chai

et al. 2023

Environ. Sci. Technol.

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Lead is known to have toxic effects on the cardiovascular system. Owing to its high concentration, transmission range, and absorption efficiency in organisms, inhalation of fine particulate matter (PM2.5)-bound lead (PM2.5-Pb) may cause significant cardiovascular damage. However, the contribution and adverse effects of PM2.5-Pb on workers and residents in non-ferrous metal smelting areas are not fully understood. In this work, the concentration and chemical speciation of PM2.5-Pb were analyzed to determine its pollution characteristics at a typical non-ferrous metal smelting site. A panel study conducted among factory workers revealed that PM2.5-Pb exposure makes an important contribution to the human absorption of Pb. Although the chemical speciation of PM2.5-Pb suggested poor water solubility, a high bioavailability was observed in mice (tissue average value: 50.1%, range: 31.1–71.1%) subjected to inhalation exposure for 8 weeks. Based on the bioavailability data, the relationship between PM2.5-Pb exposure and cardiovascular damage was evaluated in animal simulation experiments. Finally, a damage threshold and cardiovascular-specific risk assessment model were established for the non-ferrous metal smelting area. Our project not only accurately estimates the risk of PM2.5-bound heavy metals on the cardiovascular system but also offers a scientific basis for future prevention and therapy of PM2.5-Pb-related diseases.

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Taurine reduction associated with heart dysfunction after real-world PM2.5 exposure in aged mice

Cited by 12 publications

References 47 publications

Global magnitude and long‐term trend of ischemic heart disease burden attributed to household air pollution from solid fuels in 204 countries and territories, 1990–2019

Global magnitude and long‐term trend of ischemic heart disease burden attributed to household air pollution from solid fuels in 204 countries and territories, 1990–2019

Demonstrating the Applicability of Smartwatches in PM2.5 Health Impact Assessment

Contribution and Effects of PM_2.5-Bound Lead to the Cardiovascular Risk of Workers in a Non-Ferrous Metal Smelting Area Considering Chemical Speciation and Bioavailability

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Taurine reduction associated with heart dysfunction after real-world PM2.5 exposure in aged mice

Cited by 12 publications

References 47 publications

Global magnitude and long‐term trend of ischemic heart disease burden attributed to household air pollution from solid fuels in 204 countries and territories, 1990–2019

Global magnitude and long‐term trend of ischemic heart disease burden attributed to household air pollution from solid fuels in 204 countries and territories, 1990–2019

Demonstrating the Applicability of Smartwatches in PM2.5 Health Impact Assessment

Contribution and Effects of PM2.5-Bound Lead to the Cardiovascular Risk of Workers in a Non-Ferrous Metal Smelting Area Considering Chemical Speciation and Bioavailability

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Product

Resources

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Contribution and Effects of PM_2.5-Bound Lead to the Cardiovascular Risk of Workers in a Non-Ferrous Metal Smelting Area Considering Chemical Speciation and Bioavailability