2023
DOI: 10.1590/acb382323
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Taurine promotes axonal sprouting via Shh-mediated mitochondrial improvement in stroke

Abstract: Purpose: Motor function is restored by axonal sprouting in ischemic stroke. Mitochondria play a crucial role in axonal sprouting. Taurine (TAU) is known to protect the brain against experimental stroke, but its role in axonal sprouting and the underlying mechanism are unclear. Methods: We evaluated the motor function of stroke mice using the rotarod test on days 7, 14, and 28. Immunocytochemistry with biotinylated dextran amine was used to detect axonal sprouting.We observed neurite outgrowth and cell apoptosi… Show more

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