Taurine prevents ultraviolet B induced apoptosis in retinal ganglion cells

Dy, Wu; Dong-bo, Pang

doi:10.1080/15569527.2017.1339714

Cited by 6 publications

(7 citation statements)

References 21 publications

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“…The cells were treated with ACR (1.0 mM) or saline vehicle for 24 h and then were treated with TAU (5.0 mM) for additional 24 h, with or without LY294002 (Abcam, China Sigma), or MK2206 1 h pretreatment followed by previous studies. 23,24…”

Section: Methodsmentioning

confidence: 99%

Taurine attenuates acrylamide-induced apoptosis via a PI3K/AKT-dependent manner

Sun

Wang

et al. 2018

Hum Exp Toxicol

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As a potent neurotoxic agent, acrylamide (ACR) is formed in food processing at higher temperature. Taurine (TAU), a nonessential amino acid, is used to cure neurodegenerative disorders, followed by activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. In this article, we certified that antiapoptotic efficacy of TAU in vivo and vitro. ACR-treated rats received TAU by drinking water 2 weeks after ACR intoxication. The results showed that in treated rats, TAU alleviated ACR-induced neuronal apoptosis, which was associated with the activation of PI3K/AKT signaling pathway. TAU attenuated apoptosis caused by ACR through observing terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells, measure of protein expression of Bcl-2, Bax, and caspase 3 activity. TAU-induced antiapoptotic effect is PI3K/AKT-dependent, which was proved in ACR-intoxicated ventral spinal cord 4.1 cells in the presence of AKT inhibitor, MK-2206. Therefore, our results demonstrated that TAU-attenuated ACR-induced apoptosis in vivo through a PI3K/AKT-dependent manner provided new sights in the molecular mechanism of TAU protection against ACR-induced neurotoxicity.

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Section: Methodsmentioning

confidence: 99%

Taurine attenuates acrylamide-induced apoptosis via a PI3K/AKT-dependent manner

Sun

Wang

et al. 2018

Hum Exp Toxicol

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“…The taurine level detected did not significantly change in the context of hypotaurine depletion, probably due to lack of sensitivity of detection at these levels, as there were 10‐fold higher levels of intracellular taurine compared to hypotaurine present in the cells after treatment with 5 m M hypotaurine and moreover, taurine levels are reduced at higher UVA doses. This decrease seems to be related to the well‐known taurine interaction with UV as osmolyte (18‐22). Our data therefore support an interaction between hypotaurine and ROS generated by UVA irradiation of cells, resulting in its oxidation to taurine as the underlying mechanism of protection and further investigations such as intracellular ROS detection using a fluorescent probe would help clarify the role of hypotaurine as a protective agent.…”

Section: Discussionmentioning

confidence: 96%

“…The current study sought to evaluate the effect of supplemental hypotaurine uptake in HaCaT cells on cytotoxicity in the presence and absence of UVA irradiation, in order to assess whether there was evidence to support the rationale for the addition of hypotaurine to topical sunscreen and cosmetic preparations. The role of taurine, the oxidative form of hypotaurine, has been shown to have a positive effect on cell survival attributed to its osmolyte activity (19,20) and to have a photoprotective effect against UV‐induced damage via regulating the release of platelet‐activating factor from the membrane of UVB‐irradiated cells (21). To our knowledge, this is the first study that has investigated whether hypotaurine, which has been well studied for its antioxidant effects in vitro , including kinetic experiments using enzyme and radiolysis analysis and ex vivo experiments in rat placental trophoblasts and human skin fibroblasts (14–17), could have photoprotective effects.…”

Section: Discussionmentioning

confidence: 99%

“…Whilst the potential roles of hypotaurine in human skin are largely unexplored, taurine has been more thoroughly investigated in different skin models, particularly in its roles as an osmolyte involved in maintaining skin barrier homeostasis and in protecting against epidermal and keratinocyte dehydration, in addition to protection against UV-induced apoptosis in epidermal keratinocytes and retinal ganglion cells (18)(19)(20)(21)(22). The photoprotective effect of taurine has been demonstrated by upregulation of both taurine and its transporter (TAUT) following UVB exposure of human keratinocytes (22) and in a TAUT deficient mouse model showing increased sensitivity to UVB-induced immunosuppression due to a role for taurine in regulating UVB-induced hydrolysis of membrane lipids and release of the immunosuppressive molecule platelet-activating factor (21).…”

Section: Introductionmentioning

confidence: 99%

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Role of Hypotaurine in Protection against UVA‐Induced Damage in Keratinocytes

Conrado

Fanelli

McGuire

et al. 2020

Photochem & Photobiology

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Photoageing and skin cancer are major causes of morbidity and are a high cost to society. Interest in the development of photoprotective agents for inclusion in topical cosmetic and sunscreen products is profound. Recently, amino acids with a sulfinic group, notably hypotaurine, have been included as ingredients in cosmetic preparations. However, the mechanism of action of hypotaurine as a possible anti‐aging agent is unknown, despite its use as a free radical scavenger. To address this issue, we investigated hypotaurine uptake in a human keratinocyte model and examined its effect on UVR‐induced cytotoxicity. Hypotaurine was taken up by keratinocytes in a time‐ and concentration‐dependent manner, with levels remaining significantly above baseline 48 h after washout. A cytoprotective effect of pre‐incubation with 2.5–5 mMhypotaurine was shown as indicated by increased cell viability when keratinocytes were irradiated with UVA at 5 or 10 Jcm‐2, with the level of hypotaurine also significantly reduced. These findings indicate a potential cytoprotective effect of hypotaurine against the deleterious effects of UVA irradiation. This provides support for further studies to evaluate the potential photoprotective benefits of hypotaurine supplementation of topical cosmetic and sunscreen products.

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“…Thus, the simultaneous usage of UV with other chemical processes can increase the efficacy of the removal of pollutants from water. In this study, the UV radiation method was used for the removal of azithromycin from an aquatic solution [28]. Adsorption is another method used to remove pollutants from aquatic solutions [29,30].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Azithromycin Removal from Water Using UV Radiation, Fe (VI) Oxidation Process and ZnO Nanoparticles

Talaiekhozani¹,

Joudaki²,

Banisharif

et al. 2020

IJERPH

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Antibiotics are resistant to biodegradation, and their removal by biological processes is difficult. The purpose of this study was to investigate the removal of azithromycin from water using ultraviolet radiation (UV), Fe (VI) oxidation process and ZnO nanoparticles. The effect of different parameters such as pH, temperature, hydraulic retention time (HRT), the concentration of Fe (VI) and ZnO nanoparticles and UV intensity on the removal of azithromycin from water was investigated. The optimal conditions for the removal of azithromycin were a pH of 2, a temperature of 25 • C, a HRT of 15 min, and a ratio of ZnO nanoparticles to the initial concentration of azithromycin (A/P) of 0.00009 which was fitted by Langmuir isotherm. In addition, the optimal conditions for the removal of azithromycin using UV radiation were a pH of 7, a temperature of 65 • C, a HRT of 60 min, and UV radiation power of 163 mW/cm 2 . For the Fe (VI) oxidation process, the optimal conditions were a pH of 2, a temperature of 50 • C and a HRT of 20 min. Also, the optimal ratio of Fe (VI) to the initial concentration of antibiotic was between 0.011 and 0.012. The results of this study showed that the Fe (VI) oxidation process, UV radiation, and ZnO nanoparticles were efficient methods for the removal of azithromycin from water.

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Taurine prevents ultraviolet B induced apoptosis in retinal ganglion cells

Abstract: The effect of compatible osmolyte taurine on cell survival rate may play an important role in cell resistance and adaption to UVB exposure.

Cited by 6 publications

References 21 publications

Taurine attenuates acrylamide-induced apoptosis via a PI3K/AKT-dependent manner

Taurine attenuates acrylamide-induced apoptosis via a PI3K/AKT-dependent manner

Role of Hypotaurine in Protection against UVA‐Induced Damage in Keratinocytes

Comparison of Azithromycin Removal from Water Using UV Radiation, Fe (VI) Oxidation Process and ZnO Nanoparticles

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