Taurine prevents MK-801-induced shoal dispersion and altered cortisol responses in zebrafish

Franscescon, Francini; Souza, Thiele P.; Müller, Talise E.; Michelotti, Paula; Canzian, Julia; Stefanello, Flavia V.

doi:10.1016/j.pnpbp.2021.110399

Cited by 8 publications

(13 citation statements)

References 94 publications

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“…Zebrafish increasing use is a great solution to avoid species biases and focus on a robust cross-species approach, aside from being an accessible way to screen for potential novels treatments (Bruni et al, 2016; Burrows and Hannan, 2016; Gawel et al, 2019). Taurine has been demonstrated to prevent MK-801 hyperlocomotion and memory impairment in zebrafish (Franscescon et al, 2020, 2021), a finding that we could not replicate in our study. Here, taurine was not able to counteract MK-801 effects on locomotor activity or social interaction.…”

Section: Discussioncontrasting

confidence: 90%

“…to prevent MK-801 hyperlocomotion and memory impairment in zebrafish (Franscescon et al, 2020(Franscescon et al, , 2021, a finding that we could not replicate in our study.…”

Section: Discussioncontrasting

confidence: 81%

“…In regards to zebrafish, it has been demonstrated that MK-801 induces hyperlocomotion, although it is not clear which neuronal mechanisms might be involved (Menezes et al, 2015; Tran et al, 2016; Benvenutti et al, 2021; Franscescon et al, 2021). Zebrafish increasing use is a great solution to avoid species biases and focus on a robust cross-species approach, aside from being an accessible way to screen for potential novels treatments (Bruni et al, 2016; Burrows and Hannan, 2016; Gawel et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…In a mice model of prenatal immune activation, taurine was decreased in the hippocampus, striatum, temporal and parietal cortex (Winter et al, 2009; Yang et al, 2019). Finally, a recent double-blind randomized trial on 86 individuals with first-episode psychosis showed a significant improvement in schizophrenia symptoms in patients who received taurine as an adjuvant treatment as compared to placebo (O’Donnell et al, 2016), while preclinical zebrafish data further support the potential benefits of taurine in this context (Franscescon et al, 2020, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Effects of taurine in mice and zebrafish behavioral assays with translational relevance to schizophrenia

Giongo

Gallas‐Lopes

Benvenutti

et al. 2022

Preprint

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Background: Altered redox state and developmental abnormalities in glutamatergic and GABAergic transmission during development are linked to the behavioral changes associated with schizophrenia. As an amino acid that exerts antioxidant and inhibitory actions in the brain, taurine is a potential candidate to modulate biological targets relevant to this disorder. Here, we investigated in mice and zebrafish assays whether taurine prevents the behavioral changes induced by acute administration of MK-801 (dizocilpine), a glutamate NMDA receptor antagonist. Methods: C57BL/6 mice were intraperitoneally administered with saline or taurine (50, 100 and 200 mg/kg) followed by MK-801 (0.15 mg/kg). Locomotor activity, social interaction and prepulse inhibition of the acoustic startle reflex were then assessed in different sets of animals. Zebrafish were exposed to tank water or taurine (42, 150 and 400 mg/L) followed by MK-801 (5 uM); social interaction and locomotor activity were evaluated in the same test. Results: MK-801 induced hyperlocomotion and disrupted sensorimotor gating in mice; in zebrafish, it reduced sociability while increased locomotion. Taurine was mostly devoid of effects and did not counteract NMDA antagonism in mice or zebrafish. Discussion: Contradicting previous clinical and preclinical data, taurine did not show antipsychotic-like effects in the present study. However, it still warrants consideration as a preventive intervention in animal models of relevance to the prodromal phase of schizophrenia; further studies are thus necessary to evaluate whether and how taurine might benefit patients.

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Section: Discussioncontrasting

confidence: 90%

“…to prevent MK-801 hyperlocomotion and memory impairment in zebrafish (Franscescon et al, 2020(Franscescon et al, , 2021, a finding that we could not replicate in our study.…”

Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of taurine in mice and zebrafish behavioral assays with translational relevance to schizophrenia

Giongo

Gallas‐Lopes

Benvenutti

et al. 2022

Preprint

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“…Fifty adult zebrafish ( Danio rerio ) were obtained from an authorized commercial supplier (Pet Product S.R.L., Bucharest, Romania). Subjects were animals of the short-fin phenotype (3–4 months old, 3–4 cm long, 50:50 male:female ratio), which is believed to be genetically diverse and better mimic natural populations, reducing the impact of arbitrary genetic drift on inherited features [ 77 ]. Under regular conditions, zebrafish were kept in 30 L tanks filled with dechlorinated water at a maximum density of 4 fish per liter (water temperature set at 26 ± 1 °C, pH 7.0–7.2, 7.2 mg O 2 /L, conductivity 1500–1600 μS cm −1 ).…”

Section: Methodsmentioning

confidence: 99%

Origanum vulgare ssp. hirtum (Lamiaceae) Essential Oil Prevents Behavioral and Oxidative Stress Changes in the Scopolamine Zebrafish Model

et al. 2021

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Origanum vulgare ssp. hirtum has been used as medicinal herbs promoting antioxidant, anti-inflammatory, antimicrobial, and neuroprotective activities. We investigated the protective effects and the mechanism of O. vulgare ssp. hirtum essential oil (OEO) on cognitive impairment and brain oxidative stress in a scopolamine (Sco)-induced zebrafish (Danio rerio) model of cognitive impairment. Our results show that exposure to Sco (100 µM) leads to anxiety, spatial memory, and response to novelty dysfunctions, whereas the administration of OEO (25, 150, and 300 µL/L, once daily for 13 days) reduced anxiety-like behavior and improved cognitive ability, which was confirmed by behavioral tests, such as the novel tank-diving test (NTT), Y-maze test, and novel object recognition test (NOR) in zebrafish. Additionally, Sco-induced brain oxidative stress and increasing of acetylcholinesterase (AChE) activity were attenuated by the administration of OEO. The gas chromatography–mass spectrometry (GC-MS) analyses were used to elucidate the OEO composition, comprising thymol (38.82%), p-cymene (20.28%), and γ-terpinene (19.58%) as the main identified components. These findings suggest the ability of OEO to revert the Sco-induced cognitive deficits by restoring the cholinergic system activity and brain antioxidant status. Thus, OEO could be used as perspective sources of bioactive compounds, displaying valuable biological activities, with potential pharmaceutical applications.

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Taurine, an essential β-amino acid insulates against ketamine-induced experimental psychosis by enhancement of cholinergic neurotransmission, inhibition of oxidative/nitrergic imbalances, and suppression of COX-2/iNOS immunoreactions in mice

Ben‐Azu

Adebayo²,

Jarikre

et al. 2022

Metab Brain Dis

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Taurine prevents MK-801-induced shoal dispersion and altered cortisol responses in zebrafish

Cited by 8 publications

References 94 publications

Effects of taurine in mice and zebrafish behavioral assays with translational relevance to schizophrenia

Effects of taurine in mice and zebrafish behavioral assays with translational relevance to schizophrenia

Origanum vulgare ssp. hirtum (Lamiaceae) Essential Oil Prevents Behavioral and Oxidative Stress Changes in the Scopolamine Zebrafish Model

Taurine, an essential β-amino acid insulates against ketamine-induced experimental psychosis by enhancement of cholinergic neurotransmission, inhibition of oxidative/nitrergic imbalances, and suppression of COX-2/iNOS immunoreactions in mice

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