Taurine Levels in Plasma and Platelets in Insulin-Dependent and Non-Insulin-Dependent Diabetes Mellitus: Correlation with Platelet Aggregation

Franconi, Flavia; Bennardini, Federico; Mattana, Antonella; Miceli, Marco; Ciuti, Mila; Milan, Maurizio; Gironi, A; Bartomomei, Giancarlo; Anichini, Roberto; Seghieri, Giuseppe

doi:10.1007/978-1-4899-1471-2_45

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…Evidence suggests that taurine may be a conditionally essential amino acid in diseases associated with increased oxidative stress and inflammation, such as diabetes mellitus, obesity, metabolic syndrome, and atherosclerosis [9,12]. Several studies have found an inverse association between plasma taurine concentrations and fasting plasma sugar (FBS) as well as diabetes complications, suggesting taurine has a protective role in the progression of diabetes [13,14]. As a functional nutrient, taurine is involved in osmoregulation, detoxification, calcium homeostasis, neuromodulation, and cytoprotection [10,15,16].…”

mentioning

confidence: 99%

The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Maleki

Mahdavi

Hajizadeh-Sharafabad

et al. 2020

Diabetol Metab Syndr

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Background: Reduced serum level of taurine in type 2 diabetes mellitus (T2DM) was shown to be associated with the metabolic alterations and clinical complications of diabetes. Dietary supplementation with taurine may attenuate oxidative stress and inflammatory responses in T2DM as well as alleviate diabetes-induced complications. Hence, this study evaluated the effect of taurine supplementation on oxidative stress and inflammatory biomarkers in patients with T2DM. Methods: Fifty patients with T2DM were randomly allocated to two groups to consume either taurine (containing 1000 mg taurine), or placebo (containing crystalline microcellulose) three times per day for 8 weeks. Anthropometric data, dietary intake, serum total antioxidant capacity (TAC), malondialdehyde (MDA), the activities of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), serum levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were assessed before and after intervention. Results: There was a significant increase in SOD (5.1%, p = 0.004) and CAT (4.22%, p = 0.001) after 8 weeks of taurine supplementation. In addition, serum levels of MDA (26.33%, p = 0.001), hs-CRP (16.01%, p = 0.001), and TNF-α (11.65%, p = 0.03) significantly decreased in the taurine group compared with baseline. Following treatment, the taurine group had fewer serum levels of MDA (p = 0.04), hs-CRP (p = 0.002) and TNF-α (p = 0.006) than the placebo group. Also, a significant increase was observed in SOD (p = 0.007), and CAT (p = 0.001) in the taurine group compared with the placebo group. There were no differences in the serum levels of IL-6 or TAC. Conclusions: The findings of this study showed that taurine supplementation improved some oxidative stress indices and inflammatory biomarkers in patients with T2DM. Trial registration The protocol of this clinical trial is registered with the Iranian Registry of Clinical Trials (http://www. IRCT.IR, identifier: IRCT20121028011288N16).

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confidence: 99%

The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Maleki

Mahdavi

Hajizadeh-Sharafabad

et al. 2020

Diabetol Metab Syndr

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“…Taurine (2-aminoethanesulfonic acid) functions not only as an antioxidant [207][208][209][210], but also as a calcium modulator [211][212][213] with anti-hypertensive [214][215][216][217][218][219][220] and anti-sympathetic actions [219,[221][222][223], such that its intracellular depletion may link oxidative stress and sympathetic activation in diabetes. Circulating plasma and platelet taurine levels are decreased in subjects with diabetes [51,52], and taurine therapy has been reported to correct both plasma and platelet taurine concentrations and attenuate diabetes-induced abnormalities in platelet aggregation [224]. In type 1 diabetes subjects, taurine therapy was found to reduce plasma triglyceride levels [225].…”

Section: The Impact Of Antioxidants On Cardio-vascular Function and Riskmentioning

confidence: 97%

Oxidative-Nitrosative Stress as a Contributing Factor to Cardiovascular Disease in Subjects with Diabetes

Stevens¹

2005

CVP

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In diabetes, clear evidence has emerged for the presence of oxidative-nitrosative stress, which may be a consequence of a glucose-mediated imbalance of systemic antioxidant buffering capacity, coupled with increased production of free radical species. Although multiple metabolic pathways have been identified, which may contribute to oxidative stress in diabetes, the principal pathogenetic pathways and their key down-stream targets remain to be established. Evidence links oxidative stress in particular, to elevations of postprandial glucose and lipids, which also have recently emerged as major risk factors for cardiovascular events. Indeed, considerable evidence suggests that increased oxidative stress in diabetes may play an important role in the development or progression of cardiovascular disease by a number of different mechanisms, including alterations of cardiovascular sympathetic nervous system tone and integrity, elevation of acute phase reactants, disruption of endothelial function and facilitation of myocardial injury. Despite the disappointments of recent large scale clinical trials evaluating the efficacy of antioxidants in cardiovascular disease, many therapeutic agents which have been used successfully in diabetic subjects at high risk for cardiovascular disease have a mechanism of action which includes an antioxidant capacity. Therefore, incorporating an antioxidant action in future therapeutic approaches to combat cardiovascular disease complicating diabetes, appears to remain justified and warrants further evaluation.

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“…This raised the question whether taurine might be useful in the future as a complementary therapy in patients treated with low-dose aspirin, aiming to decrease the thromboembolic risk [144]. Several years later, resuming their studies on the antiaggregant effect of taurine, Franconi et al investigated its influence on platelets sampled from insulin-dependent diabetes mellitus (IDD) or non-insulin-dependent diabetes mellitus (NIDD) subjects [145,146]. They first noted a reduced level of both plasma and platelet taurine in IDD patients versus healthy subjects, and only a decrease of platelet taurine in NIDD patients.…”

Section: Evidence From Human Studiesmentioning

confidence: 99%

Taurine and Its Derivatives: Analysis of the Inhibitory Effect on Platelet Function and Their Antithrombotic Potential

Roşca

Vlădăreanu

Mirică

et al. 2022

JCM

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Taurine is a semi-essential, the most abundant free amino acid in the human body, with a six times higher concentration in platelets than any other amino acid. It is highly beneficial for the organism, has many therapeutic actions, and is currently approved for heart failure treatment in Japan. Taurine has been repeatedly reported to elicit an inhibitory action on platelet activation and aggregation, sustained by in vivo, ex vivo, and in vitro animal and human studies. Taurine showed effectiveness in several pathologies involving thrombotic diathesis, such as diabetes, traumatic brain injury, acute ischemic stroke, and others. As human prospective studies on thrombosis outcome are very difficult to carry out, there is an obvious need to validate existing findings, and bring new compelling data about the mechanisms underlying taurine and derivatives antiplatelet action and their antithrombotic potential. Chloramine derivatives of taurine proved a higher stability and pronounced selectivity for platelet receptors, raising the assumption that they could represent future potential antithrombotic agents. Considering that taurine and its analogues display permissible side effects, along with the need of finding new, alternative antithrombotic drugs with minimal side effects and long-term action, the potential clinical relevance of this fascinating nutrient and its derivatives requires further consideration.

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Taurine Levels in Plasma and Platelets in Insulin-Dependent and Non-Insulin-Dependent Diabetes Mellitus: Correlation with Platelet Aggregation

Cited by 9 publications

References 16 publications

The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial

The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Oxidative-Nitrosative Stress as a Contributing Factor to Cardiovascular Disease in Subjects with Diabetes

Taurine and Its Derivatives: Analysis of the Inhibitory Effect on Platelet Function and Their Antithrombotic Potential

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