Taurine inhibits increased MMP-2 expression in a model of oxidative stress induced by glutathione depletion in rabbit heart

Sevin, Gülnur; Özşarlak-Sözer, Gönen; Keles, Didem; Gökçe, Göksel; Reel, Buket; Ozgur, Halil Hakan; Oktay, Gülgün; Kerry, Zeliha

doi:10.1016/j.ejphar.2013.02.052

Cited by 15 publications

(14 citation statements)

References 43 publications

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“…Tau is a sulfur‐containing amino acid which has been demonstrated to have osmoregulatory, antioxidant and anti‐inflammatory property . Tau metabolite has also been shown to reduce MMP‐2 expression in glutathione depleted oxidative stress model in rabbits . In our study, Tau levels were decreased significantly in MCAo control rats which were elevated significantly in lercanidipine‐treated rats.…”

Section: Discussionmentioning

confidence: 98%

“…Thus, it can be hypothesised that elevated levels of Tau as evident from the present study might be contributing for reduced cerebral oedema, antioxidant and anti‐inflammatory effect of lercanidipine as assessed in earlier study. These results are also in agreement with the findings as mentioned above illustrating the role of neurometabolite Tau in ischaemic stroke …”

Section: Discussionmentioning

confidence: 99%

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1H NMR metabolomic profiling elucidated attenuation of neurometabolic alterations by lercanidipine in MCAo model in rats

Gupta

Sharma

Jagannathan

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Stroke is a leading cause of death and disability worldwide with limited therapeutic interventions. The current study explored proton nuclear magnetic resonance spectroscopy ( 1 H NMR)-based metabolomic approach to elucidate the effect of lercanidipine on neurometabolic alterations in transient model of ischaemic stroke in rats. Methods In the present investigation, male Wistar rats were subjected to middle cerebral artery occlusion (MCAo) for 2 h followed by reperfusion using intraluminal filament method. Rats were randomly divided into three groups as vehicle-treated sham control, vehicle-treated MCAo control and lercanidipine-treated MCAo. Vehicle or lercanidipine (0.5 mg/kg, i.p.) was administered 120 min post-reperfusion. The rat brain cortex tissues were isolated 24 h post-MCAo and were investigated by 1 H NMR spectroscopy through perchloric extraction method. Key findings A total of 23 metabolites were altered significantly after cerebral ischaemic-reperfusion injury in MCAo control as compared to sham control rats. Lercanidipine significantly reduced the levels of valine, alanine, lactate, acetate and tyrosine, while N-acetylaspartate, glutamate, glutamine, aspartate, creatine/phosphocreatine, choline, glycerophosphorylcholine, taurine, myo-inositol and adenosine di-phosphate were elevated as compared to MCAo control. Conclusions Present study illustrates effect of lercanidipine on neurometabolic alterations which might be mediated through its antioxidant, anti-inflammatory, vasodilatory and anti-apoptotic property in MCAo model of stroke.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

1H NMR metabolomic profiling elucidated attenuation of neurometabolic alterations by lercanidipine in MCAo model in rats

Gupta

Sharma

Jagannathan

et al. 2020

Journal of Pharmacy and Pharmacology

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“…In subjects with acute stroke the infusion of uric acid induced a decrease of total and active MMP-9 levels [49] and the treatment with antioxidants (polyethylene glycol-superoxide dismutase and N-acetyl-L-cysteine) reduces the MMP-9 activity in plasma and in aortic tissue homogenates of experimental models of diabetes mellitus [39] and the use of tempol (a ROS scavenger) reduces MMP-2 levels and its activity in aortic rings of animal models of renovascular hypertension [50]. Even in experimental models of oxidative stress (obtained with the depletion of glutathione), taurine inhibits MMP-2 activation in cardiac tissues [51]. Differently, the treatment with retinoic acid increases significantly MMP-9 but not MMP-2 [48] and lutein, a carotenoid, enhances MMP-9 synthesis in animal models [52].…”

Section: Discussionmentioning

confidence: 99%

Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome

Hopps

Presti

Montana

et al. 2014

Mediators of Inflammation

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Our aim was to examine some parameters of oxidative status, gelatinases, and their inhibitors and to evaluate their interrelationships in subjects with metabolic syndrome (MS). We enrolled 65 MS subjects, subdivided according to the presence or not of diabetes mellitus. We examined lipid peroxidation (expressed as thiobarbituric acid reacting substances, TBARS), protein oxidation (expressed as carbonyl groups), nitric oxide metabolites (NOx), total antioxidant status (TAS), MMP-2, MMP-9, TIMP-1, and TIMP-2. We found that MS subjects, diabetics and nondiabetics, showed an increase in TBARS, PC, and NOx. A significant decrease in TAS was observed only in nondiabetic MS subjects in comparison with diabetic MS subjects. We observed increased concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2, higher in diabetic subjects. Our data showed a positive correlation between TAS and MMP-2, TAS and MMP-9, and TAS and MMP-9/TIMP-1 and a negative correlation between TBARS and MMP-2 in diabetic MS subjects in the entire group. In MS subjects a prooxidant status and increased levels of gelatinases and their inhibitors are evident although the correlations between oxidative stress and MMPs or TIMPs are controversial and need further investigation.

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“…Taurine has potent beneficial effects on different physiological conditions, such as ischemic insult, diabetes, and oxidative stress . Under pathological conditions, the requirement for taurine is higher, and 2.5% taurine administration inhibited myocardial apoptosis during consumption of an atherogenic diet .…”

Section: Energy Metabolism For Taurine Single Usementioning

confidence: 99%

Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver

Cui

Zhang

et al. 2018

Molecular Nutrition Food Res

129

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Energy metabolism is a basic and general process, by which the body acquires and uses energy to maintain normal function, and taurine plays a vital role in energy metabolism. Taurine deficiency may cause a weak energy metabolism and energy metabolism dysfunction. Taurine biosynthetic ability is limited, and its supplementation in the diet can strengthen energy metabolism in muscle performance, cardiac function, liver activity, and adipose tissue. Combining taurine with other drugs may have a superior effect in energy metabolism. In many metabolic disorders, taurine, or the combination of taurine with other drugs, also functions as a repair treatment for damaged tissues, and acts as a promoter for the balance of energy metabolism. The present study discusses the potential roles of taurine in energy metabolism.

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Taurine inhibits increased MMP-2 expression in a model of oxidative stress induced by glutathione depletion in rabbit heart

Cited by 15 publications

References 43 publications

1H NMR metabolomic profiling elucidated attenuation of neurometabolic alterations by lercanidipine in MCAo model in rats

1H NMR metabolomic profiling elucidated attenuation of neurometabolic alterations by lercanidipine in MCAo model in rats

Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome

Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver

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