Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system

Zhao, Wei; Jia, Ling; Yang, Hanxi; Xue, Xiang; Xu, Weixiao; Cai, Jianqin; Guo, Ruijuan; Cao, Changchun

doi:10.1016/j.biopha.2018.04.150

Cited by 27 publications

(17 citation statements)

References 32 publications

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“…Sepsis-induced ALI or acute respiratory distress syndrome (ARDS) is the leading cause of mortality in septic patients [15]. Sepsis-induced ALI presents a series of clinical diseases, including pulmonary inflammatory responses and alveolar injury [16, 17]. Although many progresses have been made in the field of sepsis, the treatment effect of sepsis-induced ALI is limited.…”

Section: Discussionmentioning

confidence: 99%

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Mitochondrial Coenzyme Q Protects Sepsis-Induced Acute Lung Injury by Activating PI3K/Akt/GSK-3β/mTOR Pathway in Rats

Ren

Zeng

2019

BioMed Research International

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The aim of our study was to assess the effects of mitochondrial coenzyme Q (MitoQ) on sepsis-induced acute lung injury (ALI) and investigate its possible mechanisms. The cecal ligation and puncture (CLP) method was used to establish a septic ALI model. Rats were randomly divided into Con group, CLP group, MitoQ group, and MitoQ + LY294002 group. The survival rate of the rats was recorded, and the survival rate curve was plotted. Moreover, the ratio of wet/dry weight (W/D) in lung tissue was measured. The activity of myeloperoxidase (MPO) was measured by using the MPO colorimetric activity assay kit. The levels of high-mobility group box 1 (HMGB1) and interleukin-6 (IL-6), macrophage inflammatory protein 2 (MIP2), and keratinocyte chemoattractant (KC) were analyzed by ELISA. The histopathological changes were measured by HE staining, and the lung injury was scored. TUNEL assay was applied to detect the apoptotic cells in lung tissue. The protein expressions were detected by western blot. MitoQ increased the survival rate and alleviated pulmonary edema in septic ALI rats. In addition, MitoQ inhibited the MPO activity and decreased the levels of HMGB1 and IL-6. After treatment with MitoQ, alveolar wall edema, inflammatory cell infiltration, and red blood cell exudation were relieved. MitoQ inhibited cell apoptosis in lung tissue of septic ALI rats. Meanwhile, MitoQ treatment remarkedly increased the expression of p-Akt, p-GSK-3β, and p-mTOR but decreased Bax, caspase-3, caspase-9, Beclin-1, and LC-3II/LC-3I. The effects of MitoQ were significantly reversed by the PI3K inhibitor (LY294002). Our study demonstrated that MitoQ could protect sepsis-induced acute lung injury by activating the PI3K/Akt/GSK-3β/mTOR pathway in rats.

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Section: Discussionmentioning

confidence: 99%

“…Recently, ALI induced by sepsis has been reported to lead to lung cell apoptosis [16]. MitoQ exhibits antiapoptosis ability in a variety of diseases.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial Coenzyme Q Protects Sepsis-Induced Acute Lung Injury by Activating PI3K/Akt/GSK-3β/mTOR Pathway in Rats

Ren

Zeng

2019

BioMed Research International

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“…The level of taurine in the model group increased aer the HXC treatment, indicating that the HXC treatment had a regulatory effect on taurine metabolism. 22 It was reported that glutamine protects against the myocardial damage, liver and kidney damage, and intestinal disorders in sepsis. Arginine and glutamate are the synthetic components of glutamine in the body and clinical immunomodulators in humans.…”

Section: Discussionmentioning

confidence: 99%

Retracted Article: A high-throughput metabolomics strategy for discovering the influence of differential metabolites and metabolic pathways of huaxian capsules on sepsis-associated Qi deficiency and blood stasis syndrome

Liu

et al. 2019

RSC Adv.

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“…The results indicated that sepsis induced membrane lipid peroxidation and superoxide toxicity in the lung tissue, whereas taurine treatment significantly reversed ALI-mediated effects, suggesting that taurine may serve a protective role against oxidative stress. (20). Therefore, at 3 days post-CLP, IL-1β and TNF-α concentrations in the lung tissues of septic rats were measured by performing ELISAs.…”

Section: Resultsmentioning

confidence: 99%

“…As a cysteine derivative, taurine is highly expressed in all mammalian tissues and has important physiological effects on all cells in the body, including endogenous antioxidant, detoxification, osmoregulation, anti-inflammatory and membrane stability effects (17)(18)(19). In addition, previous studies have indicated that taurine could protect against lung injury by modulating oxidative stress, reducing cell apoptosis and decreasing the expression levels of inflammatory factors (20)(21)(22). Therefore, taurine may serve as a novel candidate for treating sepsis-induced ALI; however, the underlying molecular mechanism remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of taurine on sepsis‑induced lung injury via inhibiting the p38/MAPK signaling pathway

et al. 2021

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Sepsis, a leading cause of acute lung injury (ALI), is characterized by an overwhelming systemic inflammatory response and widespread organ injury, particularly in the lungs. Taurine, an intracellular free amino acid, has been used for the treatment of various diseases, including lung injury; however, the underlying mechanisms are unclear. The present study aimed to investigate the protective effect of taurine on septic ALI and the underlying mechanism. A septic ALI model was established by performing cecal ligation and puncture (CLP) surgery on Sprague Dawley rats. Following successful model establishment, rats were treated with taurine. The results of hematoxylin and eosin, respiratory function detection, malondialdehyde level and superoxide dismutase activity determination and ELSIA demonstrated that taurine significantly alleviated lung injury, restored respiratory function, reduced oxidation and decreased the concentrations of inflammatory factors in CLP-induced septic ALI model rats. In addition, compared with that in the ALI group, western blotting results indicated that taurine ameliorated lung epithelial injury by significantly increasing the expression levels of lung epithelial markers, E-cadherin and occludin. The western blotting results demonstrated that, compared with the control group, the p38/MAPK and NF-κB signaling pathways were significantly activated in CLP-induced septic ALI model rats, but taurine significantly suppressed ALI-mediated signaling pathway activation. To investigate the mechanism underlying taurine in the treatment of septic ALI, CLP-induced septic ALI model rats were treated with an antagonist of the p38/MAPK signaling pathway (SB203580). The effects of SB203580 on CLP-induced septic ALI model rats were similar to those of taurine. SB203580 significantly attenuated sepsis-induced lung injury and increases in IL-1β and TNF-α concentrations in the lung tissue. In addition, SB203580 promoted restoration of the injured lung tissue and respiratory function in CLP-induced septic ALI model rats. The western blotting results indicated that SB203580 significantly decreased the ratios of phosphorylated (p)-p38/p38 and p-p65/065, and increased the protein expression levels of E-cadherin and occludin compared with those in the ALI group. In summary, the present study demonstrated that taurine alleviated sepsis-induced lung injury, which was associated with suppression of the inflammatory response and oxidative stress via inhibiting the p38/MAPK signaling pathway. Therefore, the p38/MAPK signaling pathway may serve as a potential therapeutic target for the treatment of sepsis-induced ALI.

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Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system

Cited by 27 publications

References 32 publications

Mitochondrial Coenzyme Q Protects Sepsis-Induced Acute Lung Injury by Activating PI3K/Akt/GSK-3β/mTOR Pathway in Rats

Mitochondrial Coenzyme Q Protects Sepsis-Induced Acute Lung Injury by Activating PI3K/Akt/GSK-3β/mTOR Pathway in Rats

Retracted Article: A high-throughput metabolomics strategy for discovering the influence of differential metabolites and metabolic pathways of huaxian capsules on sepsis-associated Qi deficiency and blood stasis syndrome

Protective effect of taurine on sepsis‑induced lung injury via inhibiting the p38/MAPK signaling pathway

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