Taurine deficiency in dogs with dilated cardiomyopathy: 12 cases (1997–2001)

Abstract

Results suggest that consumption of certain commercial diets may be associated with low blood or plasma taurine concentrations and DCM in dogs. Taurine supplementation may result in prolonged survival times in these dogs, which is not typical for dogs with DCM. Samples should be submitted for measurement of blood and plasma taurine concentrations in dogs with DCM, and taurine supplementation is recommended while results of these analyses are pending.

Effects of Dietary Modification in Dogs with Early Chronic Valvular Disease

“…None of the dogs in the CVD group had plasma taurine concentrations that would be considered deficient (ie, ,40 nmol/mL) at any time point. 14,15 However, the fact that taurine concentrations decreased from visit 2 to visit 3 suggests that higher taurine content would be desirable in the cardiac diet.…”

“…1,[5][6][7][8][9][10][11][12][13][14][15] Dietary intake of nutrients in dogs with cardiac disease can be extremely variable. As an example, one study showed a variation of sodium intake for dogs with cardiac disease to be 14-384 mg/ 100 kcal and protein intake to be 2.3-18.8 g/100 kcal.…”

Taurine Depletion-Related Cardiomyopathy in Animals

“…They also identified that a certain breeds, such as American Cocker Spaniel and Golden Retriever, with DCM had low plasma taurine concentrations, while it was not decreased in the breeds that are more commonly afflicted with DCM. Recently, DCM associated with low taurine concentration has been reported in American Cocker Spaniel, Golden Retriever, Dalmatian, boxer, Newfoundland, Portuguese water dog, English setter, Alaskan malamute and Scottish terrier (Freeman et al, 1996;Kittleson et al, 1997;Pion et al, 1998;Fascetti et al, 2003;Alroy et al, 2005;Belanger et al, 2005). Additionally, Ko et al reported that taurine biosynthesis rate was lower in large dogs than small dogs (Ko et al, 2007), which may be associated with the greater incidence of taurine deficiency-related cardiomyopathy in large dogs than in small dogs.…”

Influência da taurina na remodelação cardíaca induzida pela exposição à fumaça do cigarro

“…Como resultado, os animais desenvolveram alterações características de cardiomiopatia (70) . O mesmo fenômeno foi observado em cães (71) . No modelo do rato, a indução farmacológica da depleção de taurina levou a alterações eletrocardiográficas, de contratilidade no músculo papilar e desordens dos filamentos contrácteis e a perdas miofibrilares na ultraestrutura (72,73,74) .…”