Taurine deficiency as a driver of aging

Abstract

Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.

Dietary supplementation with α-ionone alleviates chronic UVB exposure-induced skin photoaging in mice

“…Senescent cells secrete a range of molecules known as SASPs, including chemokines, growth factors, matrix-degrading proteases, and pro-inflammatory cytokines. 33–35 SASPs contribute significantly to skin photoaging. 6 Senescent cells induced by UV express enzymes associated with ECM remodeling, particularly MMP1/3/9.…”

Pharmacokinetics-based identification of antiviral compounds ofRheum palmatumrhizomes and roots (Dahuang)

“…S2). The mRNA of human TAUT was found to be widely expressed in various human tissues, such as the lungs, kidneys, and liver, due to the recognized role of taurine, an endogenous substrate of TAUT, as an organic osmolyte [41, 42]. In contrast, ASBT mRNA was exclusively detected in the human ileum and kidney [43, 44].…”

Photothermal Microneedle Hydrogel Patch for Refractory Soft Tissue Injuries through Thermosensitized Anti‐Inflammaging Modulation

“…[ 31–33 ] In previous studies, taurine has been found to possess significant antisenescence and anti‐inflammatory regulatory effects. [ 34–37 ] The antioxidant properties of taurine have been confirmed by many findings, including direct and indirect scavenging of reactive oxygen species (ROS). [ 38–41 ] Taurine exerts its antioxidant effects by inhibiting ROS generation and elevating antioxidant enzyme activities, as ROS production is diminished by increased antioxidase activities.…”