Taurine Concentration in Human Gliomas and Meningiomas: Tumoral, Peritumoral, and Extratumoral Tissue

Cubillos, S.; Obregón, Francisco; Vargas, MarÍa Fernanda; Salazar, Luis A.; Lima, Lucimey

doi:10.1007/978-0-387-33504-9_47

Cited by 15 publications

(13 citation statements)

References 10 publications

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“…In our study, concentrations of taurine were found to be increased in GBM areas. Increased taurine concentrations in gliomas and peritunoral tissue areas compared to extratumoral tissue areas were already detected through high performance liquid chromatography‐mass spectrometry (HPLC‐MS), and a protective role for the tumor was hypothesized 24 . Extracellular taurine levels were also found to be increased in Grade IV GBM areas and to correlate with cell proliferation 25 .…”

Section: Discussionmentioning

confidence: 98%

Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH‐mutated gliomas revealed by mass spectrometry imaging

et al. 2020

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Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor. High infiltration rates and poor therapy responses make it the deadliest glioma. The tumor metabolism is known to differ from normal one and is influenced through various factors which can lead to longer survival. Metabolites are small molecules (< 1500 Da) that display the metabolic pathways in the tissue. To determine the metabolic alterations between tumor and peritumoral tissue in human GBMs, mass spectrometry imaging (MSI) was performed on thin sections from 25 resected tumors. In addition, the GBMs were compared with six gliomas harboring a mutation in the isocitrate dehydrogenase (IDH1) gene (IDH1). With this technique, a manifold of analytes can be easily visualized on a single tissue section. Metabolites were annotated based on their accurate mass using high resolution MSI. Differences in their mean intensities in the tumor and peritumoral areas were statistically evaluated and abundances were visualized on the tissue. Enhanced levels of the antioxidants ascorbic acid, taurine, and glutathione in tumor areas suggest protective effects on the tumor. Increased levels of purine and pyrimidine metabolism compounds in GBM areas indicate the high energy demand. In accordance with these results, enhanced abundances of lactate and glutamine were detected. Moreover, decreased abundance of N-acetylaspartate, a marker for neuronal health, was measured in tumor areas. Obtained metabolic information could potentially support and personalize therapeutic approaches, hence emphasizing the suitability of MSI for GBM research.

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Section: Discussionmentioning

confidence: 98%

Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH‐mutated gliomas revealed by mass spectrometry imaging

et al. 2020

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“…Cubillos et al reported that the concentration of taurine, an amino acid that may have a protective effect or be involved in cell proliferation, was found to be higher in tumoral and peritumoral tissue of gliomas in comparison with extratumoral tissue. Nevertheless, in this paper a clear definition of the extension of peritumoral and extratumoral tissue is lacking [107]. Signal transducers and activators of transcription (STAT) proteins, which are activated by growth factors and cytokines, were shown to be present in the peritumoral area at the border between GBM and the non-invaded brain tissue [108].…”

Section: Biomolecular Characteristics Of Peritumoral Tissuementioning

confidence: 99%

Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue

D’Alessio

Proietti

Sica

et al. 2019

Cancers

194

140

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Glioblastoma (GBM) is one of the most aggressive and lethal human brain tumors. At present, GBMs are divided in primary and secondary on the basis of the mutational status of the isocitrate dehydrogenase (IDH) genes. In addition, IDH1 and IDH2 mutations are considered crucial to better define the prognosis. Although primary and secondary GBMs are histologically indistinguishable, they retain distinct genetic alterations that account for different evolution of the tumor. The high invasiveness, the propensity to disperse throughout the brain parenchyma, and the elevated vascularity make these tumors extremely recidivist, resulting in a short patient median survival even after surgical resection and chemoradiotherapy. Furthermore, GBM is considered an immunologically cold tumor. Several studies highlight a highly immunosuppressive tumor microenvironment that promotes recurrence and poor prognosis. Deeper insight into the tumor immune microenvironment, together with the recent discovery of a conventional lymphatic system in the central nervous system (CNS), led to new immunotherapeutic strategies. In the last two decades, experimental evidence from different groups proved the existence of cancer stem cells (CSCs), also known as tumor-initiating cells, that may play an active role in tumor development and progression. Recent findings also indicated the presence of highly infiltrative CSCs in the peritumoral region of GBM. This region appears to play a key role in tumor growing and recurrence. However, until recently, few studies investigated the biomolecular characteristics of the peritumoral tissue. The aim of this review is to recapitulate the pathological features of GBM and of the peritumoral region associated with progression and recurrence.

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“…The area adjacent to the tumor margin, where the angiogenic response has been observed, represents the invasion front into the neighboring tissue. In this area, differences in the level of various molecules involved in enhanced cell proliferation, edema and invasiveness have been observed (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Assessment of angiogenesis by CD105 and nestin expression in peritumor tissue of glioblastoma

et al. 2010

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Abstract. Angiogenesis in the peritumor tissue of glioblastoma (GBM) is still an open field of research. This study investigates neovascularization in the tumor surrounding areas by examining CD105 and nestin expression along with microvessel density (MVD) with the aim of establishing their possible prognostic significance. Angiogenesis was also confirmed by investigating, in vessel walls, the presence of pericytes, which are multipotent stem cells, expressing ·-smooth muscle actin (·-SMA). In our study, including 40 GBM patients, tissue samples were obtained from tumors (first area) and white matter at a distance <1 cm (second area) and between 1 and 3.5 cm (third area) from the tumor margin. CD105 and nestin were detected by immunohistochemistry in hyperplastic endothelium of GBM and peritumor tissue, and occasionally coexpressed or colocalized. Pericytes encircling hyperplastic endothelium were evident in all three areas. Univariate analysis revealed that patients with a CD105-MVD value ≥8 in the third area have a significantly shorter survival time and Cox analysis indicated an about 3.5-fold increase in death risk in the same patients. These results demonstrate that a tumor neoangiogenesis occurs in GBM peritumor tissue with intimate involvement of pericytes. CD105-MVD in the area located at a greater distance from the tumor margin carries prognostic significance.

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Taurine Concentration in Human Gliomas and Meningiomas: Tumoral, Peritumoral, and Extratumoral Tissue

Cited by 15 publications

References 10 publications

Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH‐mutated gliomas revealed by mass spectrometry imaging

Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH‐mutated gliomas revealed by mass spectrometry imaging

Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue

Assessment of angiogenesis by CD105 and nestin expression in peritumor tissue of glioblastoma

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