Taurine attenuates renal disease in chronic puromycin aminonucleoside nephropathy

Trachtman, Howard; Pizzo, R.; Futterweit, Stephen; Levine, Daniel M.; Rao, P. Syamasundar; Valderrama, Elsa; Sturman, John A.

doi:10.1152/ajprenal.1992.262.1.f117

Cited by 34 publications

(39 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre-incubation of hepatocytes with taurine could significantly decrease ROS formation. Taurine is an amino acid with a sulfonic acid group, and probably reacts with reactive oxygen species;complex formation between sulfonic acid group (SO3 -) to free ion species has been reported (Trachtman et al, 1992). Hence, the reactive oxygen species formed during carbamazepine metabolism were scavenged by taurine, this may have had a role in its protective effects in carbamazepine cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Melatonin and Taurine Against Carbamazepine-induced Toxicity in Freshly Isolated Rat Hepatocytes

2013

View full text Add to dashboard Cite

SUMMARY:Carbamazepine is widely used in a broad spectrum of psychiatric and neurological disorders. Idiosyncratic hepatotoxicity is a well-known adverse reaction associated with carbamazepine. Hepatotoxicity is rare, but a real concern when initiating therapy. It was found that oxidative stress is a potential mechanism for carbamazepine-induced hepatotoxicity. Present study evaluated the hepato protective role of taurine and melatonin against carbamazepine-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme perfusion via portal vein. Cells were treated with 400 µM carbamazepine, 1mM taurine, and 1mM melatonin. Cell death, reactive oxygen species formation, lipid peroxidation, and mitochondrial membrane depolarization were assessed as toxicity markers and the effects of taurine and melatonin administration on them were investigated. Our results showed that carbamazepine induced oxidative stress; increased ROS formation and lipid peroxidation products and also decreased mitochondrial membrane potential (∆Ψ m ). Carbamazepine caused a decrease in cellular glutathione content and an elevation in oxidized glutathione levels. Our investigation showed that preincubation of hepatocytes with taurine (1 mM) could alleviate oxidative damages induced by carbamazepine; melatonin was also a good antioxidant to protect hepatocytes against cytotoxicity induced by carbamazepine. It may be concluded that taurine and melatonin are effective antioxidants to prevent carbamazepine-induced hepatotoxicity. Following our findings, further studies are suggested on the antioxidant effects of taurine and melatonin in patients receiving carbamazepine.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective Role of Melatonin and Taurine Against Carbamazepine-induced Toxicity in Freshly Isolated Rat Hepatocytes

2013

View full text Add to dashboard Cite

show abstract

“…Uric acid as a scavenger may play a role as an antioxidizing agent in plasma by maintaining Fe2+ in the reduced state (18,19). It has also been suggested that the sulfonic acid group of taurine could bind or complex to free metal ion species (Fe2+, Cu2+) or to oxidant metalloproteins, and react with by-products of oxidation reactions, thereby preventing a direct attack by oxidants on cell membranes (20).…”

Section: Discussionmentioning

confidence: 99%

Effects of Taurine on Depletion of Erythrocyte Membrane Na-K ATPase Activity Due to Ozone Exposure or Cholesterol Enrichment.

Yamagami

Naruse

et al. 1995

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryThe objective of this study was to investigate the interrelationship between taurine and erythrocyte-membrane Na-K ATPase activity. A comparison was conducted to test whether taurine or uric acid (a water-soluble scavenger of free radicals) prevents or recovers the depletion in membrane ouabain-sensitive Na-K ATPase activity resulting from ozone exposure or cholesterol enrichment of the erythrocyte membrane. A depletion of 44% and 27% in ouabain-sensitive Na-K ATPase activity was respectively caused by ozone exposure and cholesterol enrichment. Taurine as well as uric acid partially prevented the activity loss from ozone exposure. In addition, taurine at high concentrations (from 1.5 to 4.5 mM) restored the depletion of erythrocyte-membrane Na-K ATPase activity due to ozone exposure and prevented the depletion of the enzyme activity due to cholesterol enrichment. In contrast, although the same high concentrations were used, uric acid failed to show either of the above effects. These results suggest that taurine acts (1.5-4.5 mM) polyvalently as not only an antioxidizing agent but also as a membrane stabilizer to maintain the functions of membrane Na-K ATPase, a membrane-bound protein.

show abstract

“…Studies have shown that oxidative stress leads to progression of glomerulonephritis by producing nicotinamide adenine dinucleotide phosphate oxidase [20,21]. NAC has considerable effects on free radicals and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that taurine protects renal tissues against damage from oxidative stress [18][19][20][21]. To further investigate, we studied the therapeutic efficacy of NAC and taurine in proteinuria in DN.…”

Section: Introductionmentioning

confidence: 99%

Study to Compare the Therapeutic Efficacy of N-Acetyl Cysteine and Combination of N-Acetyl Cysteine and Taurine in Proteinuria in Diabetic Nephropathy

Singh

Agarwal

Kaushik

2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Proteinuria is an established risk factor for progressive damage of kidney. This proteinuria can be effectively controlled by drugs that interrupt the renin-angiotensin-aldosterone system. However, the efficacy of N-acetyl cysteine (NAC) and taurine in prevention of diabetic nephropathy (DN) is uncertain. The role of NAC and taurine in reducing of proteinuria in patients with DN was studied.Methods: The present study was undertaken in the Postgraduate Department of Medicine of S.N. Medical College, Agra. A total of 60 patients of diabetes mellitus with evidence of nephropathy were included in the study. Twenty patients were given placebo medication (Group P), 20 patients received NAC (Group A), and remaining 20 received a combination of NAC and taurine (Group B). Each group was further subdivided according to the urinary albumin excretion in 24 hrs. Subgroup 1 -Urinary albumin excretion between 30 and 300 mg/24 hrs. Subgroup 2 -Urinary albumin excretion >300 mg/24 hrs. The stastical analysis used Student's t-test.Results: On comparison, in both microalbuminuria and macroalbuminuria patients divided into three groups; the difference in magnitude of increase in proteinuria (after NAC, NAC with taurine, and placebo administration) over 24 weeks of the study period was statistically insignificant.

show abstract

Taurine attenuates renal disease in chronic puromycin aminonucleoside nephropathy

Cited by 34 publications

References 13 publications

Protective Role of Melatonin and Taurine Against Carbamazepine-induced Toxicity in Freshly Isolated Rat Hepatocytes

Protective Role of Melatonin and Taurine Against Carbamazepine-induced Toxicity in Freshly Isolated Rat Hepatocytes

Effects of Taurine on Depletion of Erythrocyte Membrane Na-K ATPase Activity Due to Ozone Exposure or Cholesterol Enrichment.

Study to Compare the Therapeutic Efficacy of N-Acetyl Cysteine and Combination of N-Acetyl Cysteine and Taurine in Proteinuria in Diabetic Nephropathy

Contact Info

Product

Resources

About