Taurine attenuates lung ischemia–reperfusion injury after lung transplantation in rats

Guler, Leyla; Tavlasoglu, Murat; Yücel, Orhan; Güler, Adem; Şahin, Mehmet; Kürklüoğlu, Mustafa; Şirin, Yusuf Sinan; Eken, Ayşe; Gamsızkan, Mehmet; Dakak, Mehmet; Gürkök, Sedat; Genç, Onur

doi:10.1007/s00540-013-1741-2

Cited by 17 publications

(9 citation statements)

References 21 publications

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“…Pretreatment with curcumin significantly prevented the increase in MDA level and the decreased TAS level. In our previous study [1] , we demonstrated that donor treatment with taurine protected the lungs of rats against post-transplantation I/R injury in respect to histopathological and biochemical findings. Following treatment with taurine, we observed increased activities of SOD and CAT, and decreased MDA levels in I/R group compared with taurinetreatment group.…”

Section: Discussionmentioning

confidence: 99%

“…Lung transplantation has become an effective therapeutic option in the treatment of patients with various end-stage pulmonary diseases [1] such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, bronchiectasis, and primary pulmonary hypertension [2] . Lung injury induced by ischemia-reperfusion (I/R) can lead to severe primary graft failure with about 60% mortality after lung transplantation [3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ratlarda Akciğer Transplantasyonda Iskemi/Reperfüzyonun İndüklediği Oksidatif Hasara Karşı Viburnum opulus Meyve Ekstresinin Koruyucu Etkilerinin Araştırılması

Eken¹,

Yücel²,

Boşgelmez³

et al. 2017

Kafkas Univ Vet Fak Derg

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The aim of this study was to investigate the protective effect of Viburnum opulus L. fruit extract against ischemia/reperfusion (I/R)-induced oxidative stress during the lung transplantation. For this purpose, 30 female rats were firstly randomized to form of donor and recipients. After then, the rats were divided into three groups named as control, I/R, and V. opulus + I/R. Experimental rats were subjected to lung transplantation with ischemia followed by 2 h of reperfusion. Transplantation-related lung injury was evaluated by multiple parameters. A significant decrease was observed in the enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT), and the levels of glutathione and total antioxidant status (TAS), whereas the levels of malondialdehyde (MDA), total oxidant status (TOS), and protein carbonyl were significantly increased in lung tissue samples of I/R group in comparison to the control group. However, treatment with V. opulus fruit extract resulted in significant reduction of MDA and protein carbonyl levels and increment of the antioxidant system. In conclusion, V. opulus fruit extract showed protective effects against I/R-induced oxidative stress during lung transplantation probably by the radical scavenging and antioxidant activity. Therefore, this fruit extract can be efficient in the prevention of I/R-related lung toxicity. Keywords: Oxidative Stress, Transplantation, Ischemia/Reperfusion, Antioxidant Ratlarda Akciğer Transplantasyonda Iskemi/Reperfüzyonun İndüklediği Oksidatif Strese Karşı Viburnum opulus L. Meyve Ekstresinin Koruyucu Etkisinin Araştırılması ÖzetBu çalışma, akciğer transplantasyonu sırasında iskemi/reperfüzyonun indüklediği oksidatif hasara karşı Viburnum opulus L. meyve ekstresinin koruyucu etkisini araştırmak amacıyla yapılmıştır. Bu amaçla, ilk olarak donör ve alıcı oluşturmak için 30 dişi rat rastgele seçildi. Daha sonra, ratlar kontrol, I/R ve V. opulus + I/R olarak adlandırılan üç gruba ayrıldı. Deneysel ratlara iskeminin ardından 2 saat reperfüzyon ile akciğer transplantasyonu yapıldı. Transplantasyon ile ilişkili akciğer hasarı, farklı parametrelerle incelendi. Kontrol grubu ile karşılaştırıldığında I/R grubunun akciğer doku örneklerinde süperoksit dismutaz (SOD), glutatyon peroksidaz (GPx) ve katalaz (CAT) enzim aktiviteleri, glutatyon ve total antioksidan durum (TAS) düzeylerinde önemli bir azalış, malondialdehit (MDA), total oksidan durum (TOS) ve protein karbonil düzeylerinde anlamlı artış belirlendi. Bununla birlikte, V. opulus meyve ekstresi ile uygulama sonrası MDA ve protein karbonil düzeylerinde önemli azalma ve antioksidan sistemde artma saptanmıştır. Sonuç olarak, akciğer transplantasyonu sırasında I/R'nin indüklediği oksidatif strese karşı V. opulus meyve ekstresinin muhtemel radikal temizleme ve antioksidan aktivitesi ile koruyucu etkilerinin olduğunu göstermiştir. Bu nedenle, bu meyve ekstresi I/R ilişkili akciğer hasarının önlenmesinde etkili olabilir.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ratlarda Akciğer Transplantasyonda Iskemi/Reperfüzyonun İndüklediği Oksidatif Hasara Karşı Viburnum opulus Meyve Ekstresinin Koruyucu Etkilerinin Araştırılması

Eken¹,

Yücel²,

Boşgelmez³

et al. 2017

Kafkas Univ Vet Fak Derg

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“…The anti-inflammatory effect of taurine has also been attributed to the reduced secretion of interleukins (ILs) (such as IL-8), as shown by experiments in Caco-2 cells, without any participation of polymorphonuclear leukocytes (24). Accordingly, there is a growing body of preclinical data that demonstrates the anti-inflammatory effects of taurine in both neural and systemic inflammation including cardiovascular disease (26), traumatic brain injury (27), liver/gallbladder disease (28), lung injury (29), diabetes (30), cataract (31). As a result, taurine fulfills the necessary criteria to participate in the regulatory network of an immune response.…”

Section: The Role Of Taurine In Inflammationmentioning

confidence: 99%

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Baliou

Kyriakopoulos²,

Spandidos

et al. 2020

Int J Oncol

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For one century, taurine is considered as an end product of sulfur metabolism. In this review, we discuss the beneficial effect of taurine, its haloamines and taurine upregulated gene 1 (TUG1) long non-coding RNA (lncRNA) in both cancer and inflammation. We outline how taurine or its haloamines (N-Bromotaurine or N-Chlorotaurine) can induce robust and efficient responses against inflammatory diseases, providing insight into their molecular mechanisms. We also provide information about the use of taurine as a therapeutic approach to cancer. Taurine can be combined with other chemotherapeutic drugs, not only mediating durable responses in various malignancies, but also circumventing the limitations met from chemotherapeutic drugs, thus improving the therapeutic outcome. Interestingly, the lncRNA TUG1 is regarded as a promising therapeutic approach, which can overcome acquired resistance of cancer cells to selected strategies. In this regard, we can translate basic knowledge about taurine and its TUG1 lncRNA into potential therapeutic options directed against specific oncogenic signaling targets, thereby bridging the gap between bench and bedside. Contents 1. The role of taurine in inflammation 2. Formation of taurine haloamines 3. Anti-microbial properties of taurine haloamines 4. Anti-inflammatory and anti-oxidant properties of taurine haloamines 5. Therapeutic perspectives and clinical studies 6. Significance of lncRNA TUG1 lncRNA in cancer 7. The association of lncRNA TUG1 and chemoresistance 8. The role of taurine or lncRNA TUG1 as a prognostic marker 9. Conclusions

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“…Organ shortage is significant in all transplant medicine, but it is even more acute in LuTx [ 64 ] due to the high incidence of lung injury in potential deceased donors [ 64 ] and the fact that living donor transplantation is extremely complicated [ 65 ]. After transplantation, up to 30% of recipients develop primary graft dysfunction within the first 72 h after reperfusion [ 66 ], which is mainly caused by pulmonary IRI leading to significant postoperative morbidity and mortality [ 67 ].…”

Section: Comprehensive Reviewmentioning

confidence: 99%

Impact of Melatonin in Solid Organ Transplantation—Is It Time for Clinical Trials? A Comprehensive Review

Stiegler

Baušys

Leber

et al. 2018

IJMS

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Solid organ transplantation is the “gold standard” for patients with end-stage organ disease. However, the supply of donor organs is critical, with an increased organ shortage over the last few years resulting in a significant mortality of patients on waiting lists. New strategies to overcome the shortage of organs are urgently needed. Some experimental studies focus on melatonin to improve the donor pool and to protect the graft; however, current research has not reached the clinical level. Therefore, this review provides a comprehensive overview of the data available, indicating that clinical evaluation is warranted.

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Taurine attenuates lung ischemia–reperfusion injury after lung transplantation in rats

Abstract: It was demonstrated that donor treatment with taurine resulted in preservation of transplanted lung tissue in respect to histopathological and biochemical findings.

Cited by 17 publications

References 21 publications

Ratlarda Akciğer Transplantasyonda Iskemi/Reperfüzyonun İndüklediği Oksidatif Hasara Karşı Viburnum opulus Meyve Ekstresinin Koruyucu Etkilerinin Araştırılması

Ratlarda Akciğer Transplantasyonda Iskemi/Reperfüzyonun İndüklediği Oksidatif Hasara Karşı Viburnum opulus Meyve Ekstresinin Koruyucu Etkilerinin Araştırılması

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Impact of Melatonin in Solid Organ Transplantation—Is It Time for Clinical Trials? A Comprehensive Review

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