Taurine as a Micronutrient in Development and Regeneration of the Central Nervous System

Lima, Lucimey; Obregón, Francisco; Cubillos, S.; Fazzino, Fili; Jaimes, Ivan

doi:10.1080/1028415x.2001.11747379

Cited by 58 publications

(27 citation statements)

References 35 publications

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“…Because some pediatric AA solutions (TrophAmine or Aminosyn PF) containing taurine, which is a conditionally essential AA in infants, are available now [9,28], the use of these solutions would be imperative for optimal brain and retinal development [16,17]. This would also be the reason why most neonatologists choose taurine-containing solutions in premature infants since an AA solution created for older children or adults predisposes infants to developing cholestasis sooner.…”

Section: Discussionmentioning

confidence: 98%

Could lipid infusion be a risk for parenteral nutrition-associated cholestasis in low birth weight neonates?

et al. 2007

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To assess whether lipid infusion could be a risk factor for parenteral nutrition-associated cholestasis (PNAC) in low birth weight neonates, 22 newborns with cholestasis (29.8 +/- 1.6 weeks, 1298 +/- 217 g) were compared with 22 without cholestasis (29.5 +/- 1.7 weeks, 1286 +/- 363 g). The mean level of peak direct bilirubin for the cholestasis group was 4.6 mg/dl compared to 1.2 mg/dl for the noncholestasis group. A univariate analysis revealed that PNAC was significantly related to duration of fasting (p = 0.008) and parenteral nutrition (p < 0.0001), days of antibiotics use (p = 0.025), positive C-reactive protein (p = 0.018) or gastric culture (p = 0.018), and feeding intolerance (p < 0.0001). Total amino acid amount (p < 0.0001), total lipid amount (p < 0.0001), and average daily lipid amount (p = 0.002) were significantly higher in the cholestasis group than in the noncholestasis group. Conversely, prenatal administration of dexamethasone was a significant protective factor of PNAC (p = 0.008). Logistic regression analysis revealed that the cumulative amount of lipid infusion was an independent risk factor for PNAC (p = 0.041; OR 1.174; CI 1.007-1.369). We suggest that decreasing the cumulative load of amino acids and intralipids with early trophic feeding, control of infection, and prenatal administration of dexamethasone could possibly attenuate the severity of PNAC.

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Section: Discussionmentioning

confidence: 98%

Could lipid infusion be a risk for parenteral nutrition-associated cholestasis in low birth weight neonates?

et al. 2007

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“…Unfortunately, the direct contribution of taurine in BPB protection lacks solid evidence, whereas taurine uptake activity in syncytiotrophoblast cells might indicate some related functions [36]. An alternative explanation for the membrane-protective effects of taurine has been proposed based on taurine-zinc interactions which are closely related to development of structures such as the hippocampal formation [43]. Taurine and zinc have been found to stabilize the membrane and protect against lipid peroxidation in the retina [44,45].…”

Section: Discussionmentioning

confidence: 99%

Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure

Wang

et al. 2007

BMC Dev Biol

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Background: Previous study has demonstrated that dietary taurine supplement protected rats from impairments of synaptic plasticity induced by postnatal lead exposure. However, little is known about the role of taurine in the presence of prenatal and perinatal lead exposure. We investigated the possible effect of taurine supplement on prenatal and perinatal lead-induced synaptic plasticity deficit and determined developmental periods critical for the effect of taurine.

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“…12,15 The neuroprotective properties of taurine in the retina and for other neuronal cells have been previously reported. 6,7 Therefore, a taurine containing irrigation solution may be a promising tool for achieving neuroprotection during PPV. The aim of this prospective study was to evaluate the clinical safety of a taurine containing irrigation solution (AcriProTect) in PPV before a routine clinical use.…”

mentioning

confidence: 99%

SAFETY PROFILE OF A TAURINE CONTAINING IRRIGATION SOLUTION (AcriProTect) IN PARS PLANA VITRECTOMY

Yoeruek¹,

Jägle²,

Lüke³

et al. 2007

Retina

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Taurine as a Micronutrient in Development and Regeneration of the Central Nervous System

Cited by 58 publications

References 35 publications

Could lipid infusion be a risk for parenteral nutrition-associated cholestasis in low birth weight neonates?

Could lipid infusion be a risk for parenteral nutrition-associated cholestasis in low birth weight neonates?

Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure

SAFETY PROFILE OF A TAURINE CONTAINING IRRIGATION SOLUTION (AcriProTect) IN PARS PLANA VITRECTOMY

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