Taurine and enzymatically modified isoquercitrin protected against methotrexate‐induced deteriorations in the conductivity and rhythmicity of the heart in rats: Antioxidant, anti‐inflammatory, and histological architecture approach
Marwa M. Mahmoud,
Seham A. El‐Batran,
Rehab Hegazy
et al.
Abstract:Cardiotoxicity is one of the most devastating complications of cancer treatment by methotrexate (MTX). The present study aimed to investigate the potential anti‐cardiotoxic efficacy of taurine (Tau) and enzymatically modified isoquercitrin (EMIQ) alone or combined against MTX‐induced cardiotoxicity in adult male rats. A total of 36 rats were randomly divided into six groups (six animals each): control, MTX (a single i.p. dose of 20 mg/kg), EMIQ + MTX (26 mg/kg of EMIQ, p.o. for 16 days), Tau + MTX (500 mg/kg o… Show more
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