Taurine Ameliorates Hypercholesterolemia But Not Obesity in Rats Fed a Lard-Based, High-Fat Diet

Kim, Kyoung Soo; You, Jeong Soon; Kim, Jung Yeon; Chang, Kyung Ja; Yoo, Myung Chul; Song, Ran; Lee, Yeon-Ah; Lee, Sanghoon; Yang, Haesik

doi:10.1007/978-3-319-15126-7_22

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…Notably, taurine modulates the expression levels of adipokines through its conversion to taurine chloramine ( 104 ). In addition, it should be noted that the duration of taurine treatment appears to be a major determinant for the control of obesity, in the sense that prolonged administration of taurine has produced more stable and prominent results than taurine's temporary treatment for 6 weeks ( 105 ).…”

Section: Effects Of Taurine On Type 2 Diabetesmentioning

confidence: 99%

Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review)

Baliou

Adamaki

Ιωάννου

et al. 2021

Med Int

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To develop novel therapeutic methods for both diabetic and renal disorders, scientists had initially focused on elucidating the molecular mechanisms of taurine in established cell lines and mouse models. Although a large amount of data have been revealed, taurine has been confirmed to be the next step of novel promising therapeutic interventions against diabetic disorders. Taurine appears to ameliorate diabetes 1-related complications in various organs through its antioxidant, anti-inflammatory and anti-hormonal actions. In type 2 diabetes, taurine has been positively implicated in glucose homeostasis, exerting potent hypoglycemic, anti-obesity, hypotensive and hypolipidemic effects. Of particular interest is that taurine provides protection against renal dysfunction, including hypertension and proteinuria, specific glomerular and tubular disorders, acute and chronic renal conditions, and diabetic nephropathy. The ameliorative effects of taurine against renal disorders are based on its osmoregulatory properties, its association with signaling pathways and its association with the renin-angiotensin-aldosterone system (RAAS). Further clinical studies are required to ensure the importance of research findings. Types of diabetesDiabetes is a prevalent endocrine disease associated with oxidative stress. In 2014, 422 million individuals were diagnosed with diabetes worldwide, while diabetes was directly associated with 1,5 million deaths in 2012 and 2,2 million deaths indirectly through an increased risk of cardiovascular mortality and other diseases (1).Diabetes mellitus is categorized into two types according to insulin dependence. Type 1 diabetes mellitus or insulin-dependent diabetes mellitus (IDDM) (formerly known as juvenile diabetes) is characterized by hyperglycemia and hypoinsulinemia. Type 1 diabetes mellitus is considered an autoimmune disease, in which T-cells mediate the elimination of pancreatic β-cells and thereby contribute to the production of low insulin levels (2). In type 2 diabetes mellitus or non-insulin dependent diabetes mellitus (NIDDM) (formerly known as adult diabetes), insulin resistance seems to be the predominant factor and occurs from defects in insulin secretion and a low tissue sensitivity to insulin (3). Diabetes is also known to cause complications, such as cardiovascular diseases, neuropathy, nephropathy, retinopathy, foot ulcers, skin lesions and hearing impairment (4).Diabetes mellitus is associated with high blood sugar levels for a long period of time due to alterations in carbohydrate, protein and fat metabolism, which results from a dysfunction

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Section: Effects Of Taurine On Type 2 Diabetesmentioning

confidence: 99%

Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review)

Baliou

Adamaki

Ιωάννου

et al. 2021

Med Int

View full text Add to dashboard Cite

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Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver

Cui

Zhang

et al. 2018

Molecular Nutrition Food Res

129

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Energy metabolism is a basic and general process, by which the body acquires and uses energy to maintain normal function, and taurine plays a vital role in energy metabolism. Taurine deficiency may cause a weak energy metabolism and energy metabolism dysfunction. Taurine biosynthetic ability is limited, and its supplementation in the diet can strengthen energy metabolism in muscle performance, cardiac function, liver activity, and adipose tissue. Combining taurine with other drugs may have a superior effect in energy metabolism. In many metabolic disorders, taurine, or the combination of taurine with other drugs, also functions as a repair treatment for damaged tissues, and acts as a promoter for the balance of energy metabolism. The present study discusses the potential roles of taurine in energy metabolism.

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Metabolomics Profiling of the Effects of Taurine Supplementation on Dyslipidemia in a High-Fat-Diet-Induced Rat Model by 1H NMR Spectroscopy

Kim

Bang

2017

Advances in Experimental Medicine and Biology

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Metabolomics, the comprehensive study of metabolites, has merged as a potent tool for analyzing complex phenotypes and identifying biomarkers of specific physiological responses and has the potential to lead to innovative therapeutic and diagnostic schemes for many diseases. In a former report, we showed that taurine supplementation considerably ameliorated dyslipidemia in rats fed a high-caloric diet. In this work, we examined the metabolic changes that occur in rat serum after they were fed a normal diet, a high-fat diet, and a high-fat diet containing 2% taurine (tau) by NMR spectroscopy combined with a multivariate statistical analysis containing PCA, PLS-DA, and OPLS-DA. We obtained H-NMR spectra of rat serum and used pattern recognition to identify key metabolites related to taurine supplementation. We found significant changes in creatine, methionine, glutamine, and threonine as well as in lipids, all of which decreased in the Tau group. To use these changes in metabolites as novel therapeutic and diagnostic markers, it should first be investigated whether these results are reproducible in future experiments. Next, researchers should determine how these changes affect serum lipid changes. This study identified some changes in serum metabolites and demonstrated the possibility of using an NMR-based metabolomics method to explore the effects of a taurine supplement on dyslipidemia in a high-fat-diet-induced rat model.

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Taurine Ameliorates Hypercholesterolemia But Not Obesity in Rats Fed a Lard-Based, High-Fat Diet

Cited by 4 publications

References 19 publications

Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review)

Ameliorative effect of taurine against diabetes and renal‑associated disorders (Review)

Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver

Metabolomics Profiling of the Effects of Taurine Supplementation on Dyslipidemia in a High-Fat-Diet-Induced Rat Model by 1H NMR Spectroscopy

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