Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats

Abstract

<jats:p> 5-Fluorouracil is one of the most commonly used anticancer drugs for the treatment of various types of cancer but has potential adverse effects such as intestinal mucositis, renal, hepatic, and reproductive organ toxicity. Attention has been given to approaches to reduce the side effects and improve the therapeutic effectiveness of chemotherapeutic drugs. In this study, we have investigated the protective effect of taurine (Tau) on 5-fluorouracil (5-FU) induced adverse effects in Wistar rats. Animals were divided into four groups with six animals ( n = 6) in each group. Group I received vehicle only and served as control group. Groups II, III, and IV animals were given oral gavage of 5-FU at 50 mg/kg body weight for 4 days. Tau was given to the animals of groups III and IV 30 min prior to 5-FU administration. We observed marked elevation in the myeloperoxidase (MPO) activity after 5-FU administration, which was reversed by Tau pretreatment. Histological observation of liver, kidney, intestine, testis, and prostate revealed that 5-FU administration resulted in anomalies like distortion of normal cellular architecture, infiltration of inflammatory cells, and loss of cellular integrity. These histopathological changes were markedly suppressed by Tau treatment. In conclusion, biochemical and histological findings of this study suggest that Tau has strong preventive potential against complications of anticancer drug 5-FU and hence Tau may play an important role in combinational chemotherapy to enhance the therapeutic efficacy of anticancer drugs. </jats:p>

Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats

“…In addition, green tea polyphenol had also been confirmed to ameliorate chemotherapeutic agent irinotecan-induced small intestinal mucosa damage in mice [ 28 ] and gut ischemia/reperfusion injury in rats [ 29 ]. Interestingly, taurine has also been proven to ameliorate intestinal ischemia-reperfusion injury in rats [ 30 ] and the chemotherapeutic agent 5-flourouracil induced intestinal mucositis in rats [ 31 ].…”

Renal inhibition of miR-181a ameliorates 5-fluorouracil-induced mesangial cell apoptosis and nephrotoxicity

“…6a–d ). MPO is an important enzyme which secreted by inflammatory cells including neutrophils and macrophages 3 . As expected, 5-FU treatment significantly increased the activity of MPO, and this increase was inhibited after knockdown of miR-181a (Fig.…”

“…5-Fluorouracil (5-FU) is a potent antineoplastic agent widely used for the treatment of various malignancies because of its broad antitumor activity and synergistic action with other anticancer drugs 1 . However, unfortunately, 5-FU is designed to act via misincorporation of its metabolites into DNA and inhibition of thymine synthesis, and thus may not affect only cancer cells but also normal dividing cells of patients 1 – 3 . Consequently, it causes DNA damage, cell cycle termination, apoptosis and necrosis, and ultimately results in severe toxic effects and discontinuation of chemotherapy 4 .…”

“…Consequently, it causes DNA damage, cell cycle termination, apoptosis and necrosis, and ultimately results in severe toxic effects and discontinuation of chemotherapy 4 . Of note, 5-FU gets catalyzed into dihydrouracil, which subsequently can be cleaved into α-fluoro-β-alanine, ammonia, urea, and carbon dioxide in liver, leading to nephrotoxicity 3 , 4 .…”

Morus Nigra'nın sıçanlarda 5-florourasil ile oluşturulmuş gastrointestinal mukozite karşı olası tedavi ediciliği

“…Oral and gastrointestinal mucositis is an adverse effect of cancer chemotherapy and the treatment methods available currently only aim eliminating the symptoms and preventing the development of infections. In recent years, a number of agents (17)(18)(19)(20) such as interleukin receptor antagonists (11), insulin-like growth factor 1 (21), minocycline (22), uridine phosphorylase-1 inhibitors (23) and taurine (24) has been studied in order to increase the life quality and prevent and/or eliminate this toxic effect completely. The chemotherapy-induced gastrointestinal mucositis includes complex biological processes mediated by inflammatory cytokines and reactive oxygen species where oxidative stress indices and TNFα and NF-KB plays a vital role (25,26).…”