Taurine Accelerates Alcohol and Fat Metabolism of Rats with Alcoholic Fatty Liver Disease

Wu, Guanghui; Tang, Riyi; Yang, Jiancheng; Yan, Tao; Liu, Zhiyuan; Feng, Ying; Lin, Shumei; Yang, Qihui; Lv, Qiufeng; Hu, Jianmin

doi:10.1007/978-3-319-15126-7_64

Cited by 12 publications

(4 citation statements)

References 8 publications

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“…Furthermore, taurine improves hepatic inflammation by decreasing proinflammatory cytokines (IL‐1b, IL‐6 and TNF‐a) and diapedesis of lymphocytes in the liver (iNOS and CRP proteins) . Another study reported recently, that taurine might enhance alcohol and fat metabolism, both agents, which might induce liver damage . Taurine seems to be beneficial to overcome muscular cramps in cirrhotics not responding to magnesium in a trial with a single shot of an energy drink, which includes 1000 mg of taurine …”

Section: Discussionsupporting

confidence: 56%

Randomised clinical study: the effects of oral taurine 6g/day vs placebo on portal hypertension

Schwarzer

Kivaranovic

Mandorfer

et al. 2017

Aliment Pharmacol Ther

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Section: Discussionsupporting

confidence: 56%

Randomised clinical study: the effects of oral taurine 6g/day vs placebo on portal hypertension

Schwarzer

Kivaranovic

Mandorfer

et al. 2017

Aliment Pharmacol Ther

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“…The hepatic cell membrane can automatically repair after alcohol withdrawal if the damage is not serious, while taurine accelerates the repair of hepatic cells, decreasing membrane permeability and inhibiting the release of ALT and AST and improve the serum levels bilirubin [29,41]. Moreover, taurine supplementation also could downregulate these granulomatous and fibrogenic mediators in the liver of S. japonicum -infected mice which further confirmed the anti-granulomatous and anti-fibrotic effects of taurine during S. japonicum infection [42].…”

Section: Discussionmentioning

confidence: 63%

Comparison between Fibroscan and Serum Taurine for Early Diagnosis of Liver Fibrosis in Egyptian Patients Infected with HCV

Agouza¹,

Fouad²,

Ahmed³

et al. 2017

Clin Med Biochemistry

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Aim: The aim is to evaluate the role of measuring serum taurine level as an early biomarker for detection and staging of hepatic fibrosis in comparison to Fibroscan. Patients and methods:70 patients who are positive HCV are classified into five groups according to the scoring of Fibroscan. 10 healthy subjects were also enrolled as control group. Full clinical examination and complete biochemical analysis in addition to fibroscan and serum taurine as new marker are performed for all the selected patients and volunteers. Results:Results showed non-significant changes in the most Analytical data between the five groups of patients and control group, but a significant Increment in the serum level of ALT and AST in F4 Stage is noticed and marked decrease in platelets also found in F4. The most interesting point recorded is that Serum taurine levels were exhibited a value markedly lower than that recorded in control group and its decline was related to the severity of the diseases. Conclusion:It is suggested that the assessment of taurine level in sera of all hepatic patients beside fibroscan are of great value in the early diagnosis of any fibrotic changes in liver.

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“…More recently, the molecular mechanisms of the taurine hepatoprotective activity against alcohol induced damage has been clarified and, in particular, the inhibition of TLR4/MyD88 and NF-κB signaling have been identified as the target pathways [74]. Taurine administration also accelerates alcohol and lipid metabolism in alcoholic fatty liver disease [75]. In addition, taurine reduces ROS damage and increases antioxidant defense in liver previously injured by iron-overloading, resulting in anti-fibrotic and anti-apoptotic properties [76,77].…”

Section: Natural Sulfur-containing Compounds For the Treatment Of mentioning

confidence: 99%

Natural Sulfur-Containing Compounds: An Alternative Therapeutic Strategy against Liver Fibrosis

Milito

Brancaccio

D’Argenio

et al. 2019

Cells

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Liver fibrosis is a pathophysiologic process involving the accumulation of extracellular matrix proteins as collagen deposition. Advanced liver fibrosis can evolve in cirrhosis, portal hypertension and often requires liver transplantation. At the cellular level, hepatic fibrosis involves the activation of hepatic stellate cells and their transdifferentiation into myofibroblasts. Numerous pro-fibrogenic mediators including the transforming growth factor-β1, the platelet-derived growth factor, endothelin-1, toll-like receptor 4, and reactive oxygen species are key players in this process. Knowledge of the cellular and molecular mechanisms underlying hepatic fibrosis development need to be extended to find novel therapeutic strategies. Antifibrotic therapies aim to inhibit the accumulation of fibrogenic cells and/or prevent the deposition of extracellular matrix proteins. Natural products from terrestrial and marine sources, including sulfur-containing compounds, exhibit promising activities for the treatment of fibrotic pathology. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans are largely unknown. This review aims to provide a reference collection on experimentally tested natural anti-fibrotic compounds, with particular attention on sulfur-containing molecules. Their chemical structure, sources, mode of action, molecular targets, and pharmacological activity in the treatment of liver disease will be discussed.

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Taurine Accelerates Alcohol and Fat Metabolism of Rats with Alcoholic Fatty Liver Disease

Cited by 12 publications

References 8 publications

Randomised clinical study: the effects of oral taurine 6g/day vs placebo on portal hypertension

Randomised clinical study: the effects of oral taurine 6g/day vs placebo on portal hypertension

Comparison between Fibroscan and Serum Taurine for Early Diagnosis of Liver Fibrosis in Egyptian Patients Infected with HCV

Natural Sulfur-Containing Compounds: An Alternative Therapeutic Strategy against Liver Fibrosis

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