“…Neuronal axon–Schwann cell interaction(s) are essential for myelination, and myelin maintenance is a dynamic process tightly controlled by axon‐dependent transcription factors such as Krox20 and Oct6 (Murphy et al ., 1996; Decker et al ., 2006). In line with previous studies demonstrating an absence of axonal deficits in neurons of Tau−/− animals (Yuan et al ., 2008; Vossel et al ., 2010), there were no differences in mRNA levels of transcription factors that critically regulate myelination process and/or maintenance, for example, Krox20 and Oct6 (data not shown), suggesting no gross changes in myelin gene regulation of Tau−/− Schwann cells. Furthermore, supporting the involvement of Tau and other cytoskeletal elements in myelination process, previous evidence suggests that Tau strongly colocalizes with MBP in distal tips of oligodendrocytes (LoPresti et al ., 1995; Muller et al ., 1997), suggesting that transportation and/or local MBP translation may require microtubule cytoskeleton and might be controlled by Tau–Fyn interaction (Klein et al ., 2002).…”