2015
DOI: 10.1007/s12078-015-9198-3
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Tau Protein Detection in Anosmic Alzheimer’s Disease Patient’s Nasal Secretions

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Cited by 20 publications
(20 citation statements)
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“…Deficits in olfactory performance denote fundamental neuroanatomic and neurophysiologic abnormalities that are specific to the peripheral olfactory system [8, 35], olfactory bulb and/or primary olfactory cortices [36]. Olfactory dysfunction is correlated with the global level of AD pathology on postmortem examination [1], biopsy of the olfactory epithelium indicates the presence of AD pathology (e.g., amyloid-β, tau) in pathologically verified AD patients [37], and the presence of tau protein has been reported in nasal secretions of AD individuals with olfactory deficits [38]. Finally, poorer olfactory ability is associated with structural brain changes in the hippocampus and entorhinal cortex, two regions prominently affected in early stages of AD [3941].…”
Section: Discussionmentioning
confidence: 99%
“…Deficits in olfactory performance denote fundamental neuroanatomic and neurophysiologic abnormalities that are specific to the peripheral olfactory system [8, 35], olfactory bulb and/or primary olfactory cortices [36]. Olfactory dysfunction is correlated with the global level of AD pathology on postmortem examination [1], biopsy of the olfactory epithelium indicates the presence of AD pathology (e.g., amyloid-β, tau) in pathologically verified AD patients [37], and the presence of tau protein has been reported in nasal secretions of AD individuals with olfactory deficits [38]. Finally, poorer olfactory ability is associated with structural brain changes in the hippocampus and entorhinal cortex, two regions prominently affected in early stages of AD [3941].…”
Section: Discussionmentioning
confidence: 99%
“…810 Most importantly, olfactory dysfunction is correlated with AD pathology on postmortem examination, 11 biopsies of the olfactory epithelium note the presence of AD pathology (eg, Aβ) in AD patients 12 and the presence of tau protein is measurable in nasal secretions of AD individuals. 13 On a practical note, olfactory screening is routine in otorhinolaryngology, 1415 reliable, 16 and quick and easy to administer 1718 making it ideal for clinical screening in dementia.…”
Section: Introductionmentioning
confidence: 99%
“…In AD, neurofibrillary tangles have been isolated from various locations throughout the olfactory system. Studies have discovered neurofibrillary tangles in the noses of AD patients; similarly, researchers have observed increased concentrations of t-tau and p-tau in nasal secretions [85][86][87] . A study conducted in 1987 discovered neuritic plaques, neurofibrillary tangles, and neuropil threads in the olfactory bulbs of AD patients 86 .…”
Section: Olfactory Fluidsmentioning
confidence: 99%
“…On the other hand, Aβ plaques were solely situated in the anterior olfactory nucleus. The most recent study established that tau protein concentrations can be detected in the nasal secretions of AD patients 87 . Although this study was preliminary in nature, the capacity to identify tau isoforms within this abundant and readily accessible fluid permits the possibility of monitoring and diagnosing at-risk patients more efficiently and effectively.…”
Section: Olfactory Fluidsmentioning
confidence: 99%
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