volume 115, issue 3, P717-730 1991
DOI: 10.1083/jcb.115.3.717
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Abstract: Abstract. Tau protein plays a role in the extension and maintenance of neuronal processes through a direct association with microtubules . To characterize the nature of this association, we have synthesized a collection of tau protein fragments and studied their binding properties. The relatively weak affinity of tau protein for microtubules (ti10-' M) is concentrated in a large region containing three or four 18 amino acid repeated binding elements. These are separated by apparently flexible but less conserv…

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