“…These data are consistent with other studies citing higher expression of p16 ink4a in normal aged brain and in other cell types in vivo, including neurons, neuronal progenitors, and astrocytes (Al-Mashhadi, et al, 2015,Bhat, et al, 2012,Krishnamurthy, et al, 2004,Molofsky, et al, 2006,Salminen, et al, 2011. Interestingly, tau and beta-amyloid proteins have been shown to associate with and aggravate neuronal senescence in post-mortem human tissue and rodent models, respectively (Musi, et al, 2018,Wei, et al, 2016. A quantitative reference for the stereotypical number or frequency of senescent microglia/macrophages in the aged brain is currently lacking, due in part to the complexity of defining specific criteria for glial senescence in vivo.…”