Tau Pathology Triggered by Spinal Cord Injury Can Play a Critical Role in the Neurotrauma Development

Nakhjiri, Elnaz; Vafaee, Manouchehr Seyedi; Hojjati, Seyed Mohammad Massod; Shahabi, Parviz; Shahpasand, Koorosh

doi:10.1007/s12035-020-02061-7

Cited by 11 publications

(3 citation statements)

References 129 publications

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“…These products can leak into the cerebrospinal fluid or the bloodstream after CNS trauma and act as a biomarker of CNS damage. According to reports, Following SCI, in the first hours and days after SCI, the total amount of Tau in the tissue decreased and the amount of Tau secreted in serum or CSF increased indicating that the process of neuronal death and axonal injury continues [ 72 , 75 , 76 ]. In our study, the amount of Tau in the spinal tissue also decreased in the SCI group, but in the treatment group, the amount of Tau was not significantly different from the control group, which indicates the return of axon stability after receiving treatment after SCI.…”

Section: Discussionmentioning

confidence: 99%

Study of nerve cell regeneration on nanofibers containing cerium oxide nanoparticles in a spinal cord injury model in rats

Rahimi

Behroozi

Motamed

et al. 2023

J Mater Sci: Mater Med

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Since the CNS is unable to repair itself via neuronal regeneration in adult mammals, alternative therapies need to be found. The use of cerium oxide nanoparticles to repair nerve damage could be a promising approach for spinal cord reconstruction. In this study, we constructed a scaffold containing cerium oxide nanoparticles (Scaffold-CeO2) and investigated the rate of nerve cell regeneration in a rat model of spinal cord injury. The scaffold of gelatin and polycaprolactone was synthesized, and a gelatin solution containing cerium oxide nanoparticles was attached to the scaffold. For the animal study, 40 male Wistar rats were randomly divided into 4 groups (n = 10): (a) Control; (b) Spinal cord injury (SCI); (c) Scaffold (SCI + scaffold without CeO2 nanoparticles); (d) Scaffold-CeO2 (SCI + scaffold containing CeO2 nanoparticles). After creation of a hemisection SCI, scaffolds were placed at the site of injury in groups c and d, and after 7 weeks the rats were subjected to behavioral tests and then sacrificed for preparation of the spinal cord tissue to measure the expression of G-CSF, Tau and Mag proteins by Western blotting and Iba-1 protein by immunohistochemistry. The result of behavioral tests confirmed motor improvement and pain reduction in the Scaffold-CeO2 group compared to the SCI group. Decreased expression of Iba-1 and higher expression of Tau and Mag in the Scaffold-CeO2 group compared to the SCI group could be the result of nerve regeneration caused by the scaffold containing CeONPs as well as relief of pain symptoms. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Study of nerve cell regeneration on nanofibers containing cerium oxide nanoparticles in a spinal cord injury model in rats

Rahimi

Behroozi

Motamed

et al. 2023

J Mater Sci: Mater Med

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“…In experimental lesions in rats, tTAU and pTAU significantly increased at 12-and 24-h post-SCI [23], an increase negatively associated with motor performance as evaluated using the Basso, Beattie, and Bresnahan locomotor rating scale at 28 days [24]. TAU abnormalities triggered by SCI are also responsible for increases in axonal damage in the spinal cord and CSF and diffuse tau pathology in the CNS [25]. In humans, CSF tau levels showed significant increases linked to injury severity, 24 h after injury [26], and our results confirm that early TAU levels may predict motor score recovery at 6 months post-injury [5].…”

Section: Discussionmentioning

confidence: 96%

Early CSF Biomarkers and Late Functional Outcomes in Spinal Cord Injury. A Pilot Study

Capirossi¹,

Piunti²,

Fernández

et al. 2020

IJMS

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Although, biomarkers are regarded as an important tool for monitoring injury severity and treatment efficacy, and for predicting clinical evolution in many neurological diseases and disorders including spinal cord injury, there is still a lack of reliable biomarkers for the assessment of clinical course and patient outcome. In this study, a biological dataset of 60 cytokines/chemokines, growth factorsm and intracellular and extracellular matrix proteins, analyzed in CSF within 24 h of injury, was used for correlation analysis with the clinical dataset of the same patients. A heat map was generated of positive and negative correlations between biomarkers and clinical rating scale scores at discharge, and between biomarkers and changes in clinical scores during the observation period. Using very stringent statistical criteria, we found 10 molecules which correlated with clinical scores at discharge, and five molecules, which correlated with changes in clinical scores. The proposed methodology may be useful for generating hypotheses regarding “predictive” and “treatment effectiveness” biomarkers, thereby suggesting potential candidates for disease-modifying therapies using a “bed-to-bench” approach.

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“…Also, The presence of phosphorylated tau in the cerebrospinal uid is a biomarker for the severity of CNS injuries such as Multiple Sclerosis ( 64), SCI (65) and Alzheimer's disease (66). The dysfunction of Tau protein could play a vital role in the development of the injury in SCI situation (67). It has been reported that the hyperphosphorylation of tau by GSK3 in dendritic spines damages the synaptic activity (68).…”

Section: Discussionmentioning

confidence: 99%

Intraspinal Injection of Platelet-Rich Plasma Promotes Regeneration of the Spinal Cord and Improves Locomotor Function by Modulating the Apoptosis and the Wnt Signaling Pathways

Behroozi

Ramezani

Nasirinezhad

2021

Preprint

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Background: There are complex mechanisms for reducing intrinsic repair ability and neuronal regeneration following spinal cord injury (SCI). Platelet-rich plasma (PRP) is a rich source of growth factors and has been used to stimulate regeneration of peripheral nerves in degenerationtive diseases. However, only a few studies have investigated the effects of PRP on the SCI models. We examined whether PRP derived from human umbilical cord blood (HUCB-PRP) could recover motor function in animals with spinal cord injury. We also investigate the role of Wnt signaling pathway.Methods: Ault male Wistar rats were randomly divided into 6 groups (n=60) as control, sham, SCI, vehicle (SCI+platelet-poor plasma), PRP2day (SCI+injection 2 days after SCI) and PRP14day (SCI+injection 14 days after SCI). SCI was performed at the T12-T13 level. BBB tests were done weekly after injury for six weeks. caspase3 expression was determined using the Immunohistochemistry technique. The expression of GSK3β, Tau and MAG were determined using the Western blot technique. Data were analyzed by PRISM & SPSS software. Results: PRP injected animals showed a higher locomotor function recovery than those in the SCI group (p<0.0001). The level of caspase3, GSK3β and CSF- Tau reduced and MAG level in the spinal cord increased by injection of HUCB-PRP in animals with spinal cord injury. Conclusions: Injection of HUCB-PRP enhanced hind limb locomotor performance by modulation of caspase3, GSK3β, tau and MAG expression. Using HUCB-PRP could be a new therapeutic option for recovering the motor function and axonal regeneration after spinal cord injury.

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Tau Pathology Triggered by Spinal Cord Injury Can Play a Critical Role in the Neurotrauma Development

Cited by 11 publications

References 129 publications

Study of nerve cell regeneration on nanofibers containing cerium oxide nanoparticles in a spinal cord injury model in rats

Study of nerve cell regeneration on nanofibers containing cerium oxide nanoparticles in a spinal cord injury model in rats

Early CSF Biomarkers and Late Functional Outcomes in Spinal Cord Injury. A Pilot Study

Intraspinal Injection of Platelet-Rich Plasma Promotes Regeneration of the Spinal Cord and Improves Locomotor Function by Modulating the Apoptosis and the Wnt Signaling Pathways

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