Tattoo pigment in axillary lymph node mimicking calcification of breast cancer

Matsika, Admire; Srinivasan, Bhuvana; Gray, Janet Meryl; Galbraith, Christine

doi:10.1136/bcr-2013-200284

Cited by 9 publications

(14 citation statements)

References 12 publications

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“…Only for the smallest size range (0.01-1 µm), some migration has been shown previously due to diffusion into the intercellular space ( Molenda et al, 2008 ; Khetarpal et al, 2010 ; Facca et al, 2010 ). However, particles in the size range from 0.1 to 6 µm can be engulfed by phagocytic cells, which then transport the particles to the draining lymphatic nodes for presentation to T-cells ( De Geest et al, 2006 ; Molenda et al, 2008 ; De Koker et al, 2007 ; Champion et al, 2008 ; Matsika et al, 2013 ; Cheung et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Distribution of PEG-coated hollow polyelectrolyte microcapsules after introduction into the circulatory system and muscles of zebrafish

et al. 2018

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The use of polyelectrolyte multilayer microcapsules as carriers for fluorescent molecular probes is a prospective technique for monitoring the physiological characteristics of animal vasculature and interstitial environment in vivo. Polyelectrolyte microcapsules have many features that favor their use as implantable carriers of optical sensors, but little information is available on their interactions with complex living tissues, distribution or residence time following different routes of administration in the body of vertebrates. Using the common fish model, the zebrafish Danio rerio, we studied in vivo the distribution of non-biodegradable microcapsules covered with polyethylene glycol (PEG) over time in the adults and evaluated potential side effects of their delivery into the fish bloodstream and muscles. Fluorescent microcapsules administered into the bloodstream and interstitially (in concentrations that were sufficient for visualization and spectral signal recording) both showed negligible acute toxicity to the fishes during three weeks of observation. The distribution pattern of microcapsules delivered into the bloodstream was stable for at least one week, with microcapsules prevalent in capillaries-rich organs. However, after intramuscular injection, the phagocytosis of the microcapsules by immune cells was manifested, indicating considerable immunogenicity of the microcapsules despite PEG coverage. The long-term negative effects of chronic inflammation were also investigated in fish muscles by histological analysis.

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Section: Discussionmentioning

confidence: 99%

Distribution of PEG-coated hollow polyelectrolyte microcapsules after introduction into the circulatory system and muscles of zebrafish

et al. 2018

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“…In these previous reports, the microcalcifications were limited to axillary lymph nodes and were due to the metallic elements of the tattoos pigment entering into the venolymphatic system and depositing into the lymph nodes. No direct relationship was found between the presence of this artifact and tattoo characteristic such as pigment color, tattoo size, or specific location (3). It should be noted that all three of our patients' specimens were marked by using the same source bottle of red marking ink (Davidson Marking System), a proprietary marking system.…”

Section: Discussionmentioning

confidence: 82%

Technical Considerations for Red Marking Ink Use When Interpreting Specimen Radiographs: Case Report

2017

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Artifacts are universal across all imaging modalities, varying in their conspicuity and significance. In this report three patients with pathology-proven breast cancer who had densities masquerading as microcalcifications at the resection margins of the lumpectomy specimens, but had negative microscopic margins, will be discussed. It was determined that these pseudocalcifications were the result of ink precipitates from a commonly utilized tissue marking dye. This artifact was further evaluated and reproduced by utilizing a boneless chicken breast as a phantom. RSNA, 2016.

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“…When analyzing the pharmacokinetics of the drugs injected into the skin, regardless of using syringes, tattooing devices, or fractional CO 2 lasers, we believe that systemic drug absorption in drug delivery is undeniable, although differences may exist in the systemic absorption path (bloodstream or lymphatic) depending on the chemical nature and molecular weight of the drug . This is why we believe that one of the fundamental criteria that should be taken into account when choosing a medication to be used in drug delivery is if this medication and its vehicle are already systemically used or if there are safety studies for intra‐dermal use.…”

Section: Resultsmentioning

confidence: 99%

How much medication is delivered in a novel drug delivery technique that uses a tattoo machine?

et al. 2019

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Background Even though dermatologists often perform drug delivery procedures, it is necessary to assess their safety. Objective Quantify the amount of medication delivered using the MMP drug delivery technique and outline other safety parameters. Methods Using a simple and novel technique, we attempted to quantify the amount of medication delivered by weighing human skin samples before and after delivery. Results In drug delivery done on human skin using a liquid with a density of 1,271,460 μg/ml (the values expressed in this manuscript are in µg), a needling density of 570 perforations/cm2, and a needling depth of 300 microns, we estimate that 1,175 μg/cm2 were delivered (standard deviation 601 μg/cm2, standard error 190 μg/cm2). Limitations This result is only applicable to the protocol proposed in this study for the MMP drug delivery technique. Conclusion The MMP drug delivery technique injects small amounts of medication (1,175 μg/cm2) homogeneously into the dermis.

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Tattoo pigment in axillary lymph node mimicking calcification of breast cancer

Cited by 9 publications

References 12 publications

Distribution of PEG-coated hollow polyelectrolyte microcapsules after introduction into the circulatory system and muscles of zebrafish

Distribution of PEG-coated hollow polyelectrolyte microcapsules after introduction into the circulatory system and muscles of zebrafish

Technical Considerations for Red Marking Ink Use When Interpreting Specimen Radiographs: Case Report

How much medication is delivered in a novel drug delivery technique that uses a tattoo machine?

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