Tattoo Inflammation and Sarcoid Uveitis

Castro-Abeger, Alexander de

doi:10.1016/j.ophtha.2019.05.001

Cited by 1 publication

(3 citation statements)

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“…Several recent case reports have also described a relation between sarcoidosis and adverse reaction in tattoos. Those cutaneous reactions were accompanied by an abnormal chest computed tomography (CT), uveitis, and noncaseating granulomas including pigment containing multinucleated giant cells [25–30], suggesting systemic sarcoidosis and not only a local granulomatous cutaneous reaction. It was shown in a multicenter cross-sectional study of Van der Bent et al that 21.2% of sarcoidosis patients with tattoos reported tattoo related skin abnormalities including papules and nodules.…”

Section: Exposure To Metals or Silicamentioning

confidence: 99%

Section: Exposure As Well As Histological Assessment In Individual Pa...mentioning

confidence: 99%

“…Case report Assessment of skin lesions, radiology and sIL2R levels 1 week after using talc and magnesium aluminum silicate containing make-up [21] silica, aluminum, titanium, iron Case report Occupational exposures assessment and X-ray analytical electron microscopy [22] Tattoo ink Case reports Assessment of chest CT, uveitis, and noncaseating granulomas including pigment containing multinucleated giant cells after cutaneous reactions [25][26][27][28][29][30] papules and nodules. An association between tattoo related skin abnormalities and Fitzpatrick's skin type VI was observed, suggesting that genetics may play a role [31].…”

Section: Exposure As Well As Histological Assessment In Individual Pa...mentioning

confidence: 99%

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The emerging role of inorganic elements as potential antigens in sarcoidosis

Beijer

Veltkamp

2021

Current Opinion in Pulmonary Medicine

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Purpose of reviewPrevious studies mainly described a role for organic agents as possible triggers for sarcoidosis. In this review, we address recent studies suggesting a possible role for inorganic elements, such as metals or silica in sarcoidosis pathogenesis.Recent findingsSeveral epidemiological papers suggest that inorganic agents, either by environmental exposures or occupational activities, could trigger sarcoidosis. Association between inorganics and sarcoidosis is also described in several recently published case reports and studies demonstrating immunological sensitization to inorganic agents in sarcoidosis patients.Studies comparing chronic beryllium disease (CBD) and sarcoidosis suggest that although antigenic triggers may differ, underlying processes may be comparable.Besides the fact that a growing number of studies show a possible role for inorganic triggers, it is also suggested that inorganic triggered sarcoidosis may result in a more severe phenotype, including pulmonary fibrosis.SummaryWe can use the knowledge already gained on CBD pathogenesis to conduct further research into role of inorganics, such as metals and silica as antigens in sarcoidosis. Given the importance of a lymphocyte proliferation test (LPT) in diagnosing CBD, it seems obvious to also implement this test in the diagnostic work-up of sarcoidosis to identify patients with an inorganic antigenic trigger of their disease.

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Section: Exposure To Metals or Silicamentioning

confidence: 99%