TATA-box-binding protein-associated factor 15 is a novel biomarker that promotes cell proliferation and migration in gastrointestinal stromal tumor

Guo, Cheng-Ming; Li, Tang; Xu, Li; Huang, Lei

doi:10.3748/wjg.v29.i19.2932

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Further analyses including RNA pull-down, mass spectrometry, RNA immunoprecipitation, rescue experiments, and fluorescence in situ hybridization revealed that circDNAJC11 interacts with TATA-box-binding protein associated factor 15 (TAF15). TAF15 is a member of the conserved FUS-EWS-TAF15 (FET) family of RNA-binding proteins that play crucial roles in regulating gene expression such as polyadenylation, spin-capping, RNA splicing, modification, localization, export, translation, and flipping ( 49 , 50 ). CircDNAJC11 maintains MAPK6 mRNA stability through TAF15.…”

Section: Molecular Mechanism Of Circrna In Breast Cancermentioning

confidence: 99%

Molecular mechanisms of circular RNA in breast cancer: a narrative review

Li,

Zhang,

et al. 2024

Transl Cancer Res

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Background and Objective Breast cancer is presently the most prevalent cancer and the leading cause of cancer-related deaths in women worldwide. Circular RNA (circRNA) is a class of closed circRNAs lacking a 5'-end cap structure and a 3'-end polyA tail, which is highly stable and widely involved in a variety of pathophysiological processes such as cell proliferation, differentiation, and apoptosis. In recent years, accumulating studies have shown that circRNAs play an important role in the development and prognosis of breast cancer, but there are fewer literature reviews on their intrinsic molecular mechanisms which is the aim of this study. Methods This review synthesizes the findings of literature retrieved from searches of PubMed and Google Scholar databases, hand searches, and authoritative texts. Citations mainly originate from the past 3 years. The articles need to describe the role of circRNA in breast cancer; no language restrictions were imposed. Key Content and Findings This review summarizes the latest relevant literature and systematically reviews the four main mechanisms of circRNA in breast cancer from the perspective of circRNA function. At the same time, we describe the formation mechanism, characterization, and biological functions of circRNAs. Conclusions We reviewed the status of actual knowledge about circRNA biogenesis and functions and summarized novel findings regarding the molecular mechanism of circRNA in breast cancer. Meanwhile, this review explores the possibility of circRNAs for becoming new biodiagnostic indicators and therapeutic targets in breast cancer.

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Section: Molecular Mechanism Of Circrna In Breast Cancermentioning

confidence: 99%

Molecular mechanisms of circular RNA in breast cancer: a narrative review

Li,

Zhang,

et al. 2024

Transl Cancer Res

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“…WJG v29i19: The articles are overall interesting. I like the papers: (1) Liver cirrhosis topic: “Branched chain amino acids in hepatic encephalopathy and sarcopenia in liver cirrhosis: Evidence and uncertainties”[ 41 ]; and (2) Gastrointestinal stromal tumor topic: “TATA-box-binding protein-associated factor 15 is a novel biomarker that promotes cell proliferation and migration in gastrointestinal stromal tumor”[ 42 ]. The peer reviewers for these two papers performed a very good job.…”

Section: Hot Articles and Insufficient Articlesmentioning

confidence: 99%

Editor-in-Chief articles of choice and comments at the year-end of 2023

Tarnawski

2024

World J Gastroenterol

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As the Editor-in-Chief, every week prior to a new issue’s online publication, I perform a careful review of all encompassed articles, including the title, clinical and/or research importance, originality, novelty, and ratings by the peer reviewers. Based on this review, I select the papers of choice and suggest pertinent changes (e.g. , in the title) to the Company Editors responsible for publication. This process, while time-consuming, is very important for assuring the quality of publications and highlighting important articles that Readers may revisit.

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“…In GI stromal tumors (GISTs), the influence of TAF15 expression on oncogenesis and prognosis has been analyzed in a recent report[ 39 ]. In this multidisciplinary study, the authors first discovered the significant upregulation of TAF15 in tumor tissues and cell lines.…”

Section: Taf15 In Gi Cancersmentioning

confidence: 99%

Tata-box-binding protein-associated factor 15 as a new potential marker in gastrointestinal tumors

Elpek

2024

World J Gastroenterol

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In this editorial, the roles of tata-box-binding protein-associated factor 15 (TAF15) in oncogenesis, tumor behavior, and as a therapeutic target in cancers in the context of gastrointestinal (GI) tumors are discussed concerning the publication by Guo et al . TAF15 is a member of the FET protein family with a comprehensive range of cellular processes. Besides, evidence has shown that TAF15 is involved in many diseases, including cancers. TAF15 contributes to carcinogenesis and tumor behavior in many tumors. Besides, its relationship with the mitogen-activated protein kinases (MAPK) signaling pathway makes TAF15 a new target for therapy. Although, the fact that there is few studies investigating the expression of TAF15 constitutes a potential limitation in GI system, the association of TAF15 expression with aggressive tumor behavior and, similar to other organ tumors, the influence of TAF15 on the MAPK signaling pathway emphasize that this protein could serve as a new molecular biomarker to predict tumor behavior and target therapeutic intervention in GI cancers. In conclusion, more studies should be performed to better understand the prognostic and therapeutic role of TAF15 in GI tumors, especially in tumors resistant to therapy.

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TATA-box-binding protein-associated factor 15 is a novel biomarker that promotes cell proliferation and migration in gastrointestinal stromal tumor

Cited by 4 publications

References 43 publications

Molecular mechanisms of circular RNA in breast cancer: a narrative review

Molecular mechanisms of circular RNA in breast cancer: a narrative review

Editor-in-Chief articles of choice and comments at the year-end of 2023

Tata-box-binding protein-associated factor 15 as a new potential marker in gastrointestinal tumors

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